Cited 30 times in
Catechol-O-methyltransferase Val158Met polymorphism in relation to aggressive schizophrenia in a Korean population
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김세주 | - |
dc.contributor.author | 민성길 | - |
dc.date.accessioned | 2015-05-19T17:11:49Z | - |
dc.date.available | 2015-05-19T17:11:49Z | - |
dc.date.issued | 2008 | - |
dc.identifier.issn | 0924-977X | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/107686 | - |
dc.description.abstract | We examined the association between the Catechol-O-methyltransferase (COMT) Val158Met polymorphism and aggressive schizophrenia. The sample included 61 aggressive schizophrenic patients as well as 104 non-aggressive patients from psychiatric hospitals and 415 healthy volunteers in South Korea. In the case-control comparisons, there was no significant association between the aggressive schizophrenic patients and the COMT Val158Met polymorphism. Looking only at the subgroup of aggressive schizophrenic patients, however, we found a dose-dependent relationship between the Met allele and verbal aggression. In this subgroup, the Met carriers showed a higher verbal aggression score than those with the Val/Val homozygote. These findings support the hypothesized moderating role of the COMT gene in the aggressive behaviour in some schizophrenic patients, though they do not support the existence of a direct association between the COMT Val158Met polymorphism and aggressive schizophrenia case status in the Korean population. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 820~825 | - |
dc.relation.isPartOf | EUROPEAN NEUROPSYCHOPHARMACOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Age Factors | - |
dc.subject.MESH | Aggression/physiology* | - |
dc.subject.MESH | Alleles | - |
dc.subject.MESH | Case-Control Studies | - |
dc.subject.MESH | Catechol O-Methyltransferase/genetics* | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Genotype | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Korea/epidemiology | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Polymorphism, Genetic/genetics* | - |
dc.subject.MESH | Psychiatric Status Rating Scales | - |
dc.subject.MESH | Schizophrenia/epidemiology | - |
dc.subject.MESH | Schizophrenia/genetics* | - |
dc.subject.MESH | Schizophrenic Psychology* | - |
dc.subject.MESH | Young Adult | - |
dc.title | Catechol-O-methyltransferase Val158Met polymorphism in relation to aggressive schizophrenia in a Korean population | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Psychiatry (정신과학) | - |
dc.contributor.googleauthor | Youl-Ri Kim | - |
dc.contributor.googleauthor | Jeong Hyun Kim | - |
dc.contributor.googleauthor | Se Joo Kim | - |
dc.contributor.googleauthor | Dongeun Lee | - |
dc.contributor.googleauthor | Sung Kil Min | - |
dc.identifier.doi | 10.1016/j.euroneuro.2008.07.009 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00604 | - |
dc.contributor.localId | A01404 | - |
dc.relation.journalcode | J00850 | - |
dc.identifier.eissn | 1873-7862 | - |
dc.identifier.pmid | 18789857 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0924977X08001715 | - |
dc.subject.keyword | Catechol-O-methyltransferase | - |
dc.subject.keyword | Schizophrenia | - |
dc.subject.keyword | Aggression | - |
dc.subject.keyword | Genetics | - |
dc.subject.keyword | Korean | - |
dc.contributor.alternativeName | Kim, Se Joo | - |
dc.contributor.alternativeName | Min, Sung Kil | - |
dc.contributor.affiliatedAuthor | Kim, Se Joo | - |
dc.contributor.affiliatedAuthor | Min, Sung Kil | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 18 | - |
dc.citation.number | 11 | - |
dc.citation.startPage | 820 | - |
dc.citation.endPage | 825 | - |
dc.identifier.bibliographicCitation | EUROPEAN NEUROPSYCHOPHARMACOLOGY, Vol.18(11) : 820-825, 2008 | - |
dc.identifier.rimsid | 54837 | - |
dc.type.rims | ART | - |
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