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Catechol-O-methyltransferase Val158Met polymorphism in relation to aggressive schizophrenia in a Korean population

Authors
 Youl-Ri Kim  ;  Jeong Hyun Kim  ;  Se Joo Kim  ;  Dongeun Lee  ;  Sung Kil Min 
Citation
 EUROPEAN NEUROPSYCHOPHARMACOLOGY, Vol.18(11) : 820-825, 2008 
Journal Title
 EUROPEAN NEUROPSYCHOPHARMACOLOGY 
ISSN
 0924-977X 
Issue Date
2008
MeSH
Adult ; Age Factors ; Aggression/physiology* ; Alleles ; Case-Control Studies ; Catechol O-Methyltransferase/genetics* ; Female ; Genotype ; Humans ; Korea/epidemiology ; Male ; Middle Aged ; Polymorphism, Genetic/genetics* ; Psychiatric Status Rating Scales ; Schizophrenia/epidemiology ; Schizophrenia/genetics* ; Schizophrenic Psychology* ; Young Adult
Keywords
Catechol-O-methyltransferase ; Schizophrenia ; Aggression ; Genetics ; Korean
Abstract
We examined the association between the Catechol-O-methyltransferase (COMT) Val158Met polymorphism and aggressive schizophrenia. The sample included 61 aggressive schizophrenic patients as well as 104 non-aggressive patients from psychiatric hospitals and 415 healthy volunteers in South Korea. In the case-control comparisons, there was no significant association between the aggressive schizophrenic patients and the COMT Val158Met polymorphism. Looking only at the subgroup of aggressive schizophrenic patients, however, we found a dose-dependent relationship between the Met allele and verbal aggression. In this subgroup, the Met carriers showed a higher verbal aggression score than those with the Val/Val homozygote. These findings support the hypothesized moderating role of the COMT gene in the aggressive behaviour in some schizophrenic patients, though they do not support the existence of a direct association between the COMT Val158Met polymorphism and aggressive schizophrenia case status in the Korean population.
Full Text
http://www.sciencedirect.com/science/article/pii/S0924977X08001715
DOI
10.1016/j.euroneuro.2008.07.009
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Psychiatry (정신과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Se Joo(김세주) ORCID logo https://orcid.org/0000-0002-5438-8210
Min, Sung Kil(민성길)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/107686
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