Cited 11 times in
Identification and characterization of a mitochondrial iron-superoxide dismutase of Cryptosporidium parvum
DC Field | Value | Language |
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dc.contributor.author | 김주리 | - |
dc.contributor.author | 박순정 | - |
dc.date.accessioned | 2015-05-19T17:11:17Z | - |
dc.date.available | 2015-05-19T17:11:17Z | - |
dc.date.issued | 2008 | - |
dc.identifier.issn | 0932-0113 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/107668 | - |
dc.description.abstract | Cryptosporidium parvum is an intracellular protozoan parasite that causes cryptosporidiosis in mammals. In this study, we identified a gene encoding mitochondrial iron-superoxide dismutase of C. parvum (Cp-mtSOD) and characterized biochemical properties of the recombinant protein. Multiple sequence alignment of the deduced amino acid sequence of Cp-mtSOD with those of previously reported iron-containing SODs (Fe-SODs) from other protozoan parasites showed that Cp-mtSOD shares common metal-binding residues and motifs that were conserved in Fe-SODs. However, the N-terminal 26-amino acid residues of Cp-mtSOD did not show sequence identities to any other Fe-SOD sequences. Further analysis of the N-terminal presequence of Cp-mtSOD suggested that it shares common physiochemical characteristics found in mitochondria targeting sequences and predicted localization of Cp-mtSOD in the mitochondria. The recombinant Cp-mtSOD showed typical biochemical properties with other characterized Fe-SODs, including molecular structure, broad pH optimum, and sensitivity to hydrogen peroxide. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 787~795 | - |
dc.relation.isPartOf | PARASITOLOGY RESEARCH | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Amino Acid Motifs | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Binding Sites | - |
dc.subject.MESH | Cloning, Molecular | - |
dc.subject.MESH | Conserved Sequence | - |
dc.subject.MESH | Cryptosporidium parvum/enzymology* | - |
dc.subject.MESH | Cryptosporidium parvum/genetics* | - |
dc.subject.MESH | DNA, Protozoan/chemistry | - |
dc.subject.MESH | DNA, Protozoan/genetics | - |
dc.subject.MESH | Enzyme Inhibitors/pharmacology | - |
dc.subject.MESH | Enzyme Stability | - |
dc.subject.MESH | Hydrogen Peroxide/pharmacology | - |
dc.subject.MESH | Hydrogen-Ion Concentration | - |
dc.subject.MESH | Mitochondrial Proteins/chemistry | - |
dc.subject.MESH | Mitochondrial Proteins/genetics* | - |
dc.subject.MESH | Mitochondrial Proteins/metabolism | - |
dc.subject.MESH | Molecular Sequence Data | - |
dc.subject.MESH | Protein Sorting Signals | - |
dc.subject.MESH | Protein Structure, Secondary | - |
dc.subject.MESH | Protein Transport | - |
dc.subject.MESH | Protozoan Proteins/chemistry | - |
dc.subject.MESH | Protozoan Proteins/genetics* | - |
dc.subject.MESH | Protozoan Proteins/metabolism | - |
dc.subject.MESH | Recombinant Proteins/genetics | - |
dc.subject.MESH | Recombinant Proteins/metabolism | - |
dc.subject.MESH | Sequence Alignment | - |
dc.subject.MESH | Sequence Analysis, DNA | - |
dc.subject.MESH | Superoxide Dismutase/chemistry | - |
dc.subject.MESH | Superoxide Dismutase/genetics* | - |
dc.subject.MESH | Superoxide Dismutase/metabolism | - |
dc.title | Identification and characterization of a mitochondrial iron-superoxide dismutase of Cryptosporidium parvum | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Environmental Medical Biology (환경의생물학) | - |
dc.contributor.googleauthor | Jung-Mi Kang | - |
dc.contributor.googleauthor | Hyeng-Il Cheun | - |
dc.contributor.googleauthor | Juri Kim | - |
dc.contributor.googleauthor | Sung-Ung Moon | - |
dc.contributor.googleauthor | Soon-Jung Park | - |
dc.contributor.googleauthor | Tong-Soo Kim | - |
dc.contributor.googleauthor | Woon-Mok Sohn | - |
dc.contributor.googleauthor | Byoung-Kuk Na | - |
dc.identifier.doi | 10.1007/s00436-008-1041-1 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00933 | - |
dc.contributor.localId | A01545 | - |
dc.relation.journalcode | J02467 | - |
dc.identifier.eissn | 1432-1955 | - |
dc.identifier.pmid | 18551319 | - |
dc.identifier.url | http://link.springer.com/article/10.1007%2Fs00436-008-1041-1 | - |
dc.subject.keyword | Deduce Amino Acid Sequence | - |
dc.subject.keyword | Cryptosporidiosis | - |
dc.subject.keyword | Cryptosporidium Parvum | - |
dc.subject.keyword | Basic Amino Acid Residue | - |
dc.subject.keyword | Mitochondrial Iron | - |
dc.contributor.alternativeName | Kim, Ju Ri | - |
dc.contributor.alternativeName | Park, Soon Jung | - |
dc.contributor.affiliatedAuthor | Kim, Ju Ri | - |
dc.contributor.affiliatedAuthor | Park, Soon Jung | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 103 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 787 | - |
dc.citation.endPage | 795 | - |
dc.identifier.bibliographicCitation | PARASITOLOGY RESEARCH, Vol.103(4) : 787-795, 2008 | - |
dc.identifier.rimsid | 54824 | - |
dc.type.rims | ART | - |
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