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The effect of the ApoE genotype on the association between head circumference and cognition.

DC FieldValueLanguage
dc.contributor.author오병훈-
dc.contributor.author이강수-
dc.contributor.author김경란-
dc.date.accessioned2015-05-19T17:10:06Z-
dc.date.available2015-05-19T17:10:06Z-
dc.date.issued2008-
dc.identifier.issn1064-7481-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/107630-
dc.description.abstractOBJECTIVES: The aim of this study was to examine the effect of the ApoE genotype on the association between head circumference (HC) and cognition. DESIGN: Cross-sectional factorial design in which Korean version of Mini Mental State Examination (K-MMSE) score was the dependent variable with ApoE4 status as one factor and HC as the other. SETTINGS: A longitudinal cohort study of the Korea Health 21 R&D Project Clinical Research Center for Dementia. PARTICIPANTS: A total of 1,902 Koreans (599 men and 1303 women) aged over 60 years. MEASUREMENTS: Cognitive function was assessed by the K-MMSE. HC and ApoE genotyping were carried out on all subjects. RESULTS: The HC was correlated with the K-MMSE scores (r = 0.22, df = 1,525, p < 0.01), age (r = -0.11, df = 1,521, p < 0.01), educational level (r = 0.30, df = 1,525, p < 0.01), height (r = 0.50, df = 1,384, p < 0.01), and weight (r = 0.49, df = 1,445, p < 0.01). On analysis of covariance, the interaction of ApoE with HC on K-MMSE was observed after adjusting for the age, sex, educational level, height, and weight (F = 2.527, df = 4, 1, 364, p = 0.039). A test of simple main effect according to ApoE status showed that, in the ApoE epsilon 4(-) group, the mean of K-MMSE between HC quintile was not different (F = 0.517, df = 4, 1,148, p = 0.723). But in the ApoE epsilon 4(+) group, the mean of K-MMSE between HC quintile was significantly different. (F = 4.163, df = 4, 211, p = 0.003). CONCLUSION: All these findings suggest the possibility that the presence of ApoE epsilon 4 affects cognitive function only when the brain reserve is low. In other words, these findings support the structural "brain reserve hypothesis," and the effects are more pronounced in genetically predisposed individuals.-
dc.description.statementOfResponsibilityopen-
dc.format.extent819~825-
dc.relation.isPartOfAMERICAN JOURNAL OF GERIATRIC PSYCHIATRY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAged-
dc.subject.MESHAging/psychology-
dc.subject.MESHAlzheimer Disease/genetics-
dc.subject.MESHAnalysis of Variance-
dc.subject.MESHApolipoprotein E4/genetics*-
dc.subject.MESHApolipoproteins E/genetics*-
dc.subject.MESHBody Mass Index-
dc.subject.MESHBrain/anatomy & histology*-
dc.subject.MESHBrain/growth & development-
dc.subject.MESHCognition/physiology*-
dc.subject.MESHEducational Status-
dc.subject.MESHFactor Analysis, Statistical-
dc.subject.MESHFemale-
dc.subject.MESHGenotype-
dc.subject.MESHHead/anatomy & histology*-
dc.subject.MESHHumans-
dc.subject.MESHKorea-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHRegression Analysis-
dc.titleThe effect of the ApoE genotype on the association between head circumference and cognition.-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Psychiatry (정신과학)-
dc.contributor.googleauthorKyung Ran Kim-
dc.contributor.googleauthorKang Soo Lee-
dc.contributor.googleauthorEun A. Kim-
dc.contributor.googleauthorHae-Kwan Cheong-
dc.contributor.googleauthorByoung Hoon Oh-
dc.contributor.googleauthorChang Hyung Hong-
dc.identifier.doi10.1097/JGP.0b013e3181800551-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA02368-
dc.contributor.localIdA02639-
dc.contributor.localIdA00293-
dc.relation.journalcodeJ00082-
dc.identifier.eissn1545-7214-
dc.identifier.pmid18827228-
dc.identifier.urlhttp://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&AN=00019442-200810000-00005&LSLINK=80&D=ovft-
dc.subject.keywordHead circumference-
dc.subject.keywordcognition-
dc.subject.keywordK-MMSE-
dc.subject.keywordelderly-
dc.subject.keywordApoE genotype-
dc.subject.keywordbrain reserve-
dc.contributor.alternativeNameOh, Byong Hoon-
dc.contributor.alternativeNameLee, Kang Soo-
dc.contributor.alternativeNameKim, Kyung Ran-
dc.contributor.affiliatedAuthorOh, Byong Hoon-
dc.contributor.affiliatedAuthorLee, Kang Soo-
dc.contributor.affiliatedAuthorKim, Kyung Ran-
dc.rights.accessRightsnot free-
dc.citation.volume16-
dc.citation.number10-
dc.citation.startPage819-
dc.citation.endPage825-
dc.identifier.bibliographicCitationAMERICAN JOURNAL OF GERIATRIC PSYCHIATRY, Vol.16(10) : 819-825, 2008-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Psychiatry (정신과학교실) > 1. Journal Papers

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