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Repeated intravitreal injection of bevacizumab for clinically significant diabetic macular edema

Authors
 MI IN ROH  ;  SUK HO BYEON  ;  OH WOONG KWON 
Citation
 Retina- the Journal of Retinal and Vitreous Diseases, Vol.28(9) : 1314-1318, 2008 
Journal Title
 Retina- the Journal of Retinal and Vitreous Diseases 
ISSN
 0275-004X 
Issue Date
2008
Abstract
PURPOSE: Intravitreal bevacizumab (Avastin) induces a transient improvement in diabetic macular edema, necessitating repeated injections. Here, we report the results of repeated administration of intravitreal bevacizumab for the treatment of clinically significant macular edema in 31 eyes of 24 patients. METHODS: At preinjection and 1, 6, and 12 (+/-1) weeks postinjection, visual acuity (VA) with Early Treatment of Diabetic Retinopathy Study (ETDRS) and central macular thickness (CMT) evaluated using optical coherence tomography were compared with independent and paired t-tests. RESULTS: VA and CMT were not significantly different before initial and repeated injections (administered at an interval of 22.06 +/- 11.15 [SD] weeks). At 6 weeks after the first injection, VA increased significantly by 3.72 +/- 8.02 ETDRS letters (P = 0.019), and CMT was markedly decreased by 93.30 +/- 210.33 microm (P = 0.022), which returned to near baseline at 12 weeks. At 6 weeks after the second injection, VA increased significantly by 3.97 +/- 7.46 ETDRS letters (P = 0.006) and CMT decreased considerably by 118.77 +/- 178.58 microm (P = 0.001). At 12 weeks after the second injection, we observed a decrease in VA with recurrence of macular edema. CONCLUSIONS: Repeated administration of intravitreal bevacizumab (1.25 mg) may lead to the improvement of VA and CMT in patients with clinically significant macular edema.
Full Text
http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&AN=00006982-200810000-00022&LSLINK=80&D=ovft
DOI
10.1097/IAE.0b013e3181853d2a
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Ophthalmology (안과학교실) > 1. Journal Papers
Yonsei Authors
Kwon, Oh Woong(권오웅)
Roh, Mi In(노미인)
Byeon, Suk Ho(변석호) ORCID logo https://orcid.org/0000-0001-8101-0830
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/107584
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