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Evaluation of different calibrated spherical polyvinyl alcohol microspheres in transcatheter arterial chemoembolization: VX2 tumor model in rabbit liver

Authors
 Kwang-Hun Lee  ;  Eleni Liapi  ;  Veronica Prieto Ventura  ;  Manon Buijs  ;  Josephina A. Vossen  ;  Mustafa Vali  ;  Jean-Francois H. Geschwind 
Citation
 JOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY, Vol.19(7) : 1065-1069, 2008 
Journal Title
 JOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY 
ISSN
 1051-0443 
Issue Date
2008
MeSH
Animals ; Antibiotics, Antineoplastic/administration & dosage* ; Antibiotics, Antineoplastic/pharmacology ; Chemoembolization, Therapeutic/methods* ; Doxorubicin/administration & dosage* ; Doxorubicin/analogs & derivatives ; Doxorubicin/pharmacokinetics ; Liver Neoplasms, Experimental/metabolism ; Liver Neoplasms, Experimental/therapy* ; Male ; Microspheres* ; Polyvinyl Alcohol/administration & dosage* ; Polyvinyl Alcohol/chemistry ; Porosity ; Rabbits
Keywords
PVA ; polyvinyl alcohol ; TACE ; transcatheter arterial chemoembolization
Abstract
PURPOSE: To assess whether porosity and compressibility of calibrated spherical polyvinyl alcohol (PVA) microspheres affect doxorubicin plasma and tumor concentrations after transcatheter arterial chemoembolization (TACE) in a VX2 rabbit model. MATERIALS AND METHODS: Fifteen rabbits were divided into three groups of five rabbits each. Three different types of calibrated spherical PVA microspheres with variable levels of porosity and compressibility were blindly evaluated. TACE was performed by injecting a mixture of doxorubicin (5 mg) and iodized oil (0.5 mL) followed by injection of the embolic material (0.3-0.5 mL). Plasma concentrations of doxorubicin and doxorubicinol were analyzed 20, 40, 60, and 120 minutes and 2 days after TACE, and liver tissue and tumor doxorubicin concentrations were measured 2 days after TACE. RESULTS: All calibrated spherical PVA microspheres showed similar patterns of plasma doxorubicin and doxorubicinol release and tumor concentration of doxorubicin. There were no significant differences of drug levels in either plasma or tumor in each group (P > .05). CONCLUSIONS: After TACE in a rabbit model of liver cancer, testing of three different types of spherical PVA microspheres with varying degrees of porosity and compressibility showed no significant differences in the plasma doxorubicin release pattern and tumor doxorubicin uptake
Files in This Item:
T200801282.pdf Download
DOI
10.1016/j.jvir.2008.02.023
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
Lee, Kwang Hun(이광훈)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/107574
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