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Characterization and TCR variable region gene use of mouse resident nasal gammadelta T lymphocytes

DC Field Value Language
dc.contributor.author김창훈-
dc.date.accessioned2015-05-19T17:05:37Z-
dc.date.available2015-05-19T17:05:37Z-
dc.date.issued2008-
dc.identifier.issn0741-5400-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/107494-
dc.description.abstractTissue-resident gammadelta T lymphocytes, such as dendritic epidermal T cells, intestinal intraepithelial lymphocytes (IEL), and resident pulmonary lymphocytes, are known to support local tissue homeostasis and host defense. Inhaled antigens, toxins, and microorganisms first interact with the immune system through contact with the nasal mucosa. Herein, we characterized two populations of resident nasal lymphocytes (RNL) that are present in the nasal mucosa: nasal IEL (nIEL) and nasal lamina propria lymphocytes (nLPL). gammadelta TCR+ and alphabeta TCR+ nIEL and nLPL were detected by immunofluorescent staining. Mononuclear cells (5-15%) were CD3+ RNL by FACS analysis. Among the CD3+ RNL, 20-30% were GL3+ gammadelta T cells, which were double-negative for CD4 and CD8 and predominantly expressed a Vgamma4/Vdelta1 TCR. These results demonstrate that RNL might be crucial for the host defense and tissue homeostasis in the nasal mucosa.-
dc.description.statementOfResponsibilityopen-
dc.format.extent1259~1263-
dc.relation.isPartOfJOURNAL OF LEUKOCYTE BIOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAnimals-
dc.subject.MESHFlow Cytometry-
dc.subject.MESHImmunoglobulin Variable Region*-
dc.subject.MESHMice-
dc.subject.MESHNasal Mucosa/immunology*-
dc.subject.MESHReceptors, Antigen, T-Cell/genetics*-
dc.subject.MESHReceptors, Antigen, T-Cell/immunology-
dc.subject.MESHReceptors, Antigen, T-Cell, alpha-beta/genetics-
dc.subject.MESHReceptors, Antigen, T-Cell, alpha-beta/immunology-
dc.subject.MESHReceptors, Antigen, T-Cell, gamma-delta/genetics*-
dc.subject.MESHReceptors, Antigen, T-Cell, gamma-delta/immunology*-
dc.subject.MESHReverse Transcriptase Polymerase Chain Reaction-
dc.subject.MESHSpleen/immunology-
dc.subject.MESHT-Lymphocytes/immunology*-
dc.titleCharacterization and TCR variable region gene use of mouse resident nasal gammadelta T lymphocytes-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Otorhinolaryngology (이비인후과학)-
dc.contributor.googleauthorChang-Hoon Kim-
dc.contributor.googleauthorDeborah A. Witherden-
dc.contributor.googleauthorWendy L. Havran-
dc.identifier.doi18667688-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA01050-
dc.relation.journalcodeJ01559-
dc.identifier.eissn1938-3673-
dc.identifier.pmid18667688-
dc.subject.keywordresident nasal lymphocyte-
dc.subject.keywordnasal intraepithelial lymphocyte-
dc.subject.keywordnasal lamina propria lymphocyte-
dc.contributor.alternativeNameKim, Chang Hoon-
dc.contributor.affiliatedAuthorKim, Chang Hoon-
dc.rights.accessRightsfree-
dc.citation.volume84-
dc.citation.number5-
dc.citation.startPage1259-
dc.citation.endPage1263-
dc.identifier.bibliographicCitationJOURNAL OF LEUKOCYTE BIOLOGY, Vol.84(5) : 1259-1263, 2008-
dc.identifier.rimsid56903-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Otorhinolaryngology (이비인후과학교실) > 1. Journal Papers

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