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Characterization and TCR variable region gene use of mouse resident nasal gammadelta T lymphocytes
DC Field | Value | Language |
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dc.contributor.author | 김창훈 | - |
dc.date.accessioned | 2015-05-19T17:05:37Z | - |
dc.date.available | 2015-05-19T17:05:37Z | - |
dc.date.issued | 2008 | - |
dc.identifier.issn | 0741-5400 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/107494 | - |
dc.description.abstract | Tissue-resident gammadelta T lymphocytes, such as dendritic epidermal T cells, intestinal intraepithelial lymphocytes (IEL), and resident pulmonary lymphocytes, are known to support local tissue homeostasis and host defense. Inhaled antigens, toxins, and microorganisms first interact with the immune system through contact with the nasal mucosa. Herein, we characterized two populations of resident nasal lymphocytes (RNL) that are present in the nasal mucosa: nasal IEL (nIEL) and nasal lamina propria lymphocytes (nLPL). gammadelta TCR+ and alphabeta TCR+ nIEL and nLPL were detected by immunofluorescent staining. Mononuclear cells (5-15%) were CD3+ RNL by FACS analysis. Among the CD3+ RNL, 20-30% were GL3+ gammadelta T cells, which were double-negative for CD4 and CD8 and predominantly expressed a Vgamma4/Vdelta1 TCR. These results demonstrate that RNL might be crucial for the host defense and tissue homeostasis in the nasal mucosa. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 1259~1263 | - |
dc.relation.isPartOf | JOURNAL OF LEUKOCYTE BIOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Flow Cytometry | - |
dc.subject.MESH | Immunoglobulin Variable Region* | - |
dc.subject.MESH | Mice | - |
dc.subject.MESH | Nasal Mucosa/immunology* | - |
dc.subject.MESH | Receptors, Antigen, T-Cell/genetics* | - |
dc.subject.MESH | Receptors, Antigen, T-Cell/immunology | - |
dc.subject.MESH | Receptors, Antigen, T-Cell, alpha-beta/genetics | - |
dc.subject.MESH | Receptors, Antigen, T-Cell, alpha-beta/immunology | - |
dc.subject.MESH | Receptors, Antigen, T-Cell, gamma-delta/genetics* | - |
dc.subject.MESH | Receptors, Antigen, T-Cell, gamma-delta/immunology* | - |
dc.subject.MESH | Reverse Transcriptase Polymerase Chain Reaction | - |
dc.subject.MESH | Spleen/immunology | - |
dc.subject.MESH | T-Lymphocytes/immunology* | - |
dc.title | Characterization and TCR variable region gene use of mouse resident nasal gammadelta T lymphocytes | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Otorhinolaryngology (이비인후과학) | - |
dc.contributor.googleauthor | Chang-Hoon Kim | - |
dc.contributor.googleauthor | Deborah A. Witherden | - |
dc.contributor.googleauthor | Wendy L. Havran | - |
dc.identifier.doi | 18667688 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01050 | - |
dc.relation.journalcode | J01559 | - |
dc.identifier.eissn | 1938-3673 | - |
dc.identifier.pmid | 18667688 | - |
dc.subject.keyword | resident nasal lymphocyte | - |
dc.subject.keyword | nasal intraepithelial lymphocyte | - |
dc.subject.keyword | nasal lamina propria lymphocyte | - |
dc.contributor.alternativeName | Kim, Chang Hoon | - |
dc.contributor.affiliatedAuthor | Kim, Chang Hoon | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 84 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 1259 | - |
dc.citation.endPage | 1263 | - |
dc.identifier.bibliographicCitation | JOURNAL OF LEUKOCYTE BIOLOGY, Vol.84(5) : 1259-1263, 2008 | - |
dc.identifier.rimsid | 56903 | - |
dc.type.rims | ART | - |
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