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Clinical Significance of Margin Status in Postoperative Radiotherapy for Extremity and Truncal Soft-Tissue Sarcoma

DC FieldValueLanguage
dc.contributor.author신규호-
dc.contributor.author한수봉-
dc.contributor.author김귀언-
dc.contributor.author김용배-
dc.contributor.author노재경-
dc.contributor.author서창옥-
dc.contributor.author성진실-
dc.date.accessioned2015-05-19T17:05:31Z-
dc.date.available2015-05-19T17:05:31Z-
dc.date.issued2008-
dc.identifier.issn0360-3016-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/107491-
dc.description.abstractPURPOSE: To evaluate whether adjuvant radiotherapy (RT) in extremity and truncal soft-tissue sarcoma (STS) patients with microscopically positive or close margins after excision can achieve comparable local control to that of excision with negative margin plus RT. METHODS AND MATERIALS: A total of 150 patients (111 extremity and 39 trunk cases) treated with conserving surgery and adjuvant RT was analyzed. All surgical margins were classified as being a negative margin or a positive or close margin based on pathologic margin width. RT was delivered with a shrinking-field technique in 150 patients (median, 63 Gy). RESULTS: All patients were divided into two groups: (A) excision with negative margins plus RT (n = 56) and (B) excision with positive or close margins plus RT (n = 94). Overall, the 5-year local failure-free survival in all patients was 72.9%, and no significant differences were found between the two groups (Group A, 74.7%; Group B, 71.6%). High tumor grade was found to be a significant predictor of local failure. However, Group A was superior to Group B in distant metastasis-free survival (p = 0.02). No significant differences were shown in overall survival between the two groups. CONCLUSIONS: In our series, margin status did not predict for LF when adjuvant RT was used. We believe that when adjuvant RT is used, re-resection may not be necessary for selected patients with positive or close pathologic margins in the management of extremity and truncal STS patients.-
dc.description.statementOfResponsibilityopen-
dc.format.extent139~144-
dc.relation.isPartOfINTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdolescent-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHAged, 80 and over-
dc.subject.MESHChild-
dc.subject.MESHDisease-Free Survival-
dc.subject.MESHExtremities-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHNeoplasm, Residual-
dc.subject.MESHRadiotherapy Dosage-
dc.subject.MESHRadiotherapy, Adjuvant/adverse effects-
dc.subject.MESHRegression Analysis-
dc.subject.MESHSarcoma/mortality-
dc.subject.MESHSarcoma/pathology*-
dc.subject.MESHSarcoma/radiotherapy*-
dc.subject.MESHSarcoma/surgery-
dc.subject.MESHSoft Tissue Neoplasms/mortality-
dc.subject.MESHSoft Tissue Neoplasms/pathology*-
dc.subject.MESHSoft Tissue Neoplasms/radiotherapy*-
dc.subject.MESHSoft Tissue Neoplasms/surgery-
dc.subject.MESHTreatment Failure-
dc.titleClinical Significance of Margin Status in Postoperative Radiotherapy for Extremity and Truncal Soft-Tissue Sarcoma-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학)-
dc.contributor.googleauthorYONG BAE KIM-
dc.contributor.googleauthorKYU HO SHIN-
dc.contributor.googleauthorJINSIL SEONG-
dc.contributor.googleauthorJAE KYUNG ROH-
dc.contributor.googleauthorGWI EON KIM-
dc.contributor.googleauthorSOO BONG HAHN-
dc.contributor.googleauthorCHANG OK SUH-
dc.identifier.doi17919843-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA02086-
dc.contributor.localIdA04293-
dc.contributor.localIdA00321-
dc.contributor.localIdA01290-
dc.contributor.localIdA01919-
dc.contributor.localIdA01956-
dc.contributor.localIdA00744-
dc.relation.journalcodeJ01157-
dc.identifier.eissn1879-355X-
dc.identifier.pmid17919843-
dc.identifier.urlhttp://www.sciencedirect.com/science/article/pii/S0360301607010255-
dc.subject.keywordAdolescent-
dc.subject.keywordAdult-
dc.subject.keywordAged-
dc.subject.keywordAged, 80 and over-
dc.subject.keywordChild-
dc.subject.keywordDisease-Free Survival-
dc.subject.keywordExtremities-
dc.subject.keywordFemale-
dc.subject.keywordHumans-
dc.subject.keywordMale-
dc.subject.keywordMiddle Aged-
dc.subject.keywordNeoplasm, Residual-
dc.subject.keywordRadiotherapy Dosage-
dc.subject.keywordRadiotherapy, Adjuvant/adverse effects-
dc.subject.keywordRegression Analysis-
dc.subject.keywordSarcoma/mortality-
dc.subject.keywordSarcoma/pathology*-
dc.subject.keywordSarcoma/radiotherapy*-
dc.subject.keywordSarcoma/surgery-
dc.subject.keywordSoft Tissue Neoplasms/mortality-
dc.subject.keywordSoft Tissue Neoplasms/pathology*-
dc.subject.keywordSoft Tissue Neoplasms/radiotherapy*-
dc.subject.keywordSoft Tissue Neoplasms/surgery-
dc.subject.keywordTreatment Failure-
dc.contributor.alternativeNameShin, Kyoo Ho-
dc.contributor.alternativeNameHahn, Soo Bong-
dc.contributor.alternativeNameKim, Gwi Eon-
dc.contributor.alternativeNameKim, Yong Bae-
dc.contributor.alternativeNameRoh, Jae Kyung-
dc.contributor.alternativeNameSuh, Chang Ok-
dc.contributor.alternativeNameSeong, Jin Sil-
dc.contributor.affiliatedAuthorShin, Kyoo Ho-
dc.contributor.affiliatedAuthorHahn, Soo Bong-
dc.contributor.affiliatedAuthorKim, Gwi Eon-
dc.contributor.affiliatedAuthorRoh, Jae Kyung-
dc.contributor.affiliatedAuthorSuh, Chang Ok-
dc.contributor.affiliatedAuthorSeong, Jin Sil-
dc.contributor.affiliatedAuthorKim, Yong Bae-
dc.rights.accessRightsnot free-
dc.citation.volume70-
dc.citation.number1-
dc.citation.startPage139-
dc.citation.endPage144-
dc.identifier.bibliographicCitationINTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, Vol.70(1) : 139-144, 2008-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Orthopedic Surgery (정형외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiation Oncology (방사선종양학교실) > 1. Journal Papers

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