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Characterization of a hapten-induced, murine model with multiple features of atopic dermatitis: Structural, immunologic, and biochemical changes following single versus multiple oxazolone challenges

DC FieldValueLanguage
dc.contributor.author이승헌-
dc.date.accessioned2015-05-19T17:02:21Z-
dc.date.available2015-05-19T17:02:21Z-
dc.date.issued2008-
dc.identifier.issn0022-202X-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/107405-
dc.description.abstractAtopic dermatitis (AD) is a chronic dermatosis bearing clinical, histological, and immunologic similarities to chronic allergic contact dermatitis (ACD). AD shows a Th2 cell-dominant inflammatory infiltrate, elevated serum IgE levels, a permeability barrier abnormality, and Staphylococcus aureus colonization. Repeated hapten challenges reportedly produce a Th2-like hypersensitivity reaction (Th2-like HR). Here, 9-10 challenges with oxazolone (Ox) to hairless mice also produced a chronic Th2-like HR. Permeability barrier function and expression of differentiation proteins, filaggrin, loricrin, and involucrin, became abnormal. CRTH-positive Th2-dominant inflammatory infiltrate, with increased IL-4 expression, and a large increase in serum IgE levels were observed. The barrier abnormality was associated with decreased stratum corneum (SC) ceramide content and impaired lamellar body secretion, resulting in abnormal lamellar membranes, as in human AD. Furthermore, as in human AD, epidermal serine protease activity in SC increased and expression of two lamellar body-derived antimicrobial peptides, CRAMP and mBD3, declined after Ox challenges, paralleling the decrease of their human homologues in AD. Thus, multiple Ox challenges to normal murine skin produce a chronic Th2-like HR, with multiple features of human AD. Because of its reproducibility, predictability, and low cost, this model could prove useful for evaluating both pathogenic mechanisms and potential therapies for AD.-
dc.description.statementOfResponsibilityopen-
dc.format.extent79~86-
dc.relation.isPartOfJOURNAL OF INVESTIGATIVE DERMATOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAnimals-
dc.subject.MESHAntimicrobial Cationic Peptides/analysis-
dc.subject.MESHCathelicidins-
dc.subject.MESHCeramides/analysis-
dc.subject.MESHDNA-Binding Proteins/analysis-
dc.subject.MESHDermatitis, Atopic/immunology*-
dc.subject.MESHDermatitis, Atopic/metabolism-
dc.subject.MESHDisease Models, Animal-
dc.subject.MESHFemale-
dc.subject.MESHHaptens/administration & dosage*-
dc.subject.MESHHaptens/immunology-
dc.subject.MESHImmunity, Innate/drug effects-
dc.subject.MESHImmunoglobulin E/blood-
dc.subject.MESHLipids/analysis-
dc.subject.MESHMice-
dc.subject.MESHMice, Hairless-
dc.subject.MESHOxazolone/administration & dosage*-
dc.subject.MESHOxazolone/immunology-
dc.subject.MESHPermeability-
dc.subject.MESHSerine Endopeptidases/metabolism-
dc.subject.MESHTh2 Cells/immunology-
dc.subject.MESHTranscription Factors/analysis-
dc.titleCharacterization of a hapten-induced, murine model with multiple features of atopic dermatitis: Structural, immunologic, and biochemical changes following single versus multiple oxazolone challenges-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Dermatology (피부과학)-
dc.contributor.googleauthorMao-Qiang Man-
dc.contributor.googleauthorYutaka Hatano-
dc.contributor.googleauthorSeung H. Lee-
dc.contributor.googleauthorMona Man-
dc.contributor.googleauthorSandra Chang-
dc.contributor.googleauthorKenneth R. Feingold-
dc.contributor.googleauthorDonald Y.M. Leung-
dc.contributor.googleauthorWalter Holleran-
dc.contributor.googleauthorYoshikazu Uchida-
dc.contributor.googleauthorPeter M. Elias-
dc.identifier.doi10.1038/sj.jid.5701011-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA02931-
dc.relation.journalcodeJ01469-
dc.identifier.eissn1523-1747-
dc.identifier.pmid17671515-
dc.subject.keywordAnimals-
dc.subject.keywordAntimicrobial Cationic Peptides/analysis-
dc.subject.keywordCathelicidins-
dc.subject.keywordCeramides/analysis-
dc.subject.keywordDNA-Binding Proteins/analysis-
dc.subject.keywordDermatitis, Atopic/immunology*-
dc.subject.keywordDermatitis, Atopic/metabolism-
dc.subject.keywordDisease Models, Animal-
dc.subject.keywordFemale-
dc.subject.keywordHaptens/administration & dosage*-
dc.subject.keywordHaptens/immunology-
dc.subject.keywordImmunity, Innate/drug effects-
dc.subject.keywordImmunoglobulin E/blood-
dc.subject.keywordLipids/analysis-
dc.subject.keywordMice-
dc.subject.keywordMice, Hairless-
dc.subject.keywordOxazolone/administration & dosage*-
dc.subject.keywordOxazolone/immunology-
dc.subject.keywordPermeability-
dc.subject.keywordSerine Endopeptidases/metabolism-
dc.subject.keywordTh2 Cells/immunology-
dc.subject.keywordTranscription Factors/analysis-
dc.contributor.alternativeNameLee, Seung Hun-
dc.contributor.affiliatedAuthorLee, Seung Hun-
dc.rights.accessRightsfree-
dc.citation.volume128-
dc.citation.number1-
dc.citation.startPage79-
dc.citation.endPage86-
dc.identifier.bibliographicCitationJOURNAL OF INVESTIGATIVE DERMATOLOGY, Vol.128(1) : 79-86, 2008-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Dermatology (피부과학교실) > 1. Journal Papers

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