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Nitroglycerin- and nicardipine-induced hypotension does not affect cerebral oxygen saturation and postoperative cognitive function in patients undergoing orthognathic surgery

DC FieldValueLanguage
dc.contributor.author김기준-
dc.contributor.author신양식-
dc.contributor.author이성진-
dc.contributor.author정영수-
dc.contributor.author최승호-
dc.date.accessioned2015-05-19T17:00:56Z-
dc.date.available2015-05-19T17:00:56Z-
dc.date.issued2008-
dc.identifier.issn0278-2391-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/107367-
dc.description.abstractPURPOSE: The aim of this study was to investigate the influence of nitroglycerin- and nicardipine-induced hypotension on regional cerebral oxygen saturation (rSO(2)) and postoperative cognitive function in patients undergoing orthognathic surgery. PATIENTS AND METHODS: Sixty adult patients scheduled for orthognathic surgery were randomly assigned to either the nitroglycerin group (group 1) or nicardipine group (group 2). After induction of anesthesia, hypotension was induced with continuous infusion of nitroglycerin or nicardipine. Mean arterial pressure (MAP), heart rate (HR), and rSO(2) were measured at the following time points: before induction of anesthesia, immediately before commencing induced hypotension, at 30 and 60 minutes after induced hypotension, and immediately before the end of surgery. Cerebral desaturation was defined as a reduction of rSO(2) less than 75% of baseline for > or = 15 seconds. The Mini Mental State Examination (MMSE) was conducted before surgery and then repeated after 1 week. RESULTS: Baseline rSO(2) values were similar in the 2 groups. There were no significant differences in rSO(2) values between the 2 groups. Cerebral desaturation was not observed in any of the patients. Both nitroglycerin and nicardipine reduced MAP and increased HR during induced hypotension as compared with the baseline values (P < .05). No differences in MAP and HR during baseline and induced hypotension were observed between the 2 groups. Decreased MMSE scores were not observed in any of the patients. CONCLUSION: Cerebral oxygen saturation and postoperative cognitive function were not impaired during nitroglycerin- and nicardipine-induced hypotension in patients undergoing orthognathic surgery.-
dc.description.statementOfResponsibilityopen-
dc.format.extent2104~2109-
dc.relation.isPartOfJournal of Oral and Maxillofacial Surgery-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHBlood Pressure/drug effects-
dc.subject.MESHBrief Psychiatric Rating Scale-
dc.subject.MESHCerebrovascular Circulation/drug effects*-
dc.subject.MESHCognition/drug effects*-
dc.subject.MESHDouble-Blind Method-
dc.subject.MESHFemale-
dc.subject.MESHHeart Rate/drug effects-
dc.subject.MESHHumans-
dc.subject.MESHHypotension, Controlled/methods*-
dc.subject.MESHInfusions, Intravenous-
dc.subject.MESHMale-
dc.subject.MESHNicardipine/administration & dosage-
dc.subject.MESHNicardipine/pharmacology*-
dc.subject.MESHNitroglycerin/administration & dosage-
dc.subject.MESHNitroglycerin/pharmacology*-
dc.subject.MESHOral Surgical Procedures*-
dc.subject.MESHOxygen/blood-
dc.subject.MESHProspective Studies-
dc.subject.MESHSpectroscopy, Near-Infrared-
dc.subject.MESHVasodilator Agents/administration & dosage-
dc.subject.MESHVasodilator Agents/pharmacology*-
dc.titleNitroglycerin- and nicardipine-induced hypotension does not affect cerebral oxygen saturation and postoperative cognitive function in patients undergoing orthognathic surgery-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Anesthesiology (마취통증의학)-
dc.contributor.googleauthorSeung Ho Choi-
dc.contributor.googleauthorSung Jin Lee-
dc.contributor.googleauthorYoung-Soo Jung-
dc.contributor.googleauthorYang-Sik Shin-
dc.contributor.googleauthorDong Byeong Jun-
dc.contributor.googleauthorKyung Ho Hwang-
dc.contributor.googleauthorJia Liu-
dc.contributor.googleauthorKi Jun Kim-
dc.identifier.doi10.1016/j.joms.2008.06.041-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00340-
dc.contributor.localIdA02123-
dc.contributor.localIdA02872-
dc.contributor.localIdA03655-
dc.contributor.localIdA04101-
dc.relation.journalcodeJ01659-
dc.identifier.pmid18848109-
dc.identifier.urlhttp://www.sciencedirect.com/science/article/pii/S0278239108010379-
dc.subject.keywordAdult-
dc.subject.keywordBlood Pressure/drug effects-
dc.subject.keywordBrief Psychiatric Rating Scale-
dc.subject.keywordCerebrovascular Circulation/drug effects*-
dc.subject.keywordCognition/drug effects*-
dc.subject.keywordDouble-Blind Method-
dc.subject.keywordFemale-
dc.subject.keywordHeart Rate/drug effects-
dc.subject.keywordHumans-
dc.subject.keywordHypotension, Controlled/methods*-
dc.subject.keywordInfusions, Intravenous-
dc.subject.keywordMale-
dc.subject.keywordNicardipine/administration & dosage-
dc.subject.keywordNicardipine/pharmacology*-
dc.subject.keywordNitroglycerin/administration & dosage-
dc.subject.keywordNitroglycerin/pharmacology*-
dc.subject.keywordOral Surgical Procedures*-
dc.subject.keywordOxygen/blood-
dc.subject.keywordProspective Studies-
dc.subject.keywordSpectroscopy, Near-Infrared-
dc.subject.keywordVasodilator Agents/administration & dosage-
dc.subject.keywordVasodilator Agents/pharmacology*-
dc.contributor.alternativeNameKim, Ki Jun-
dc.contributor.alternativeNameShin, Yang Sik-
dc.contributor.alternativeNameLee, Sung Jin-
dc.contributor.alternativeNameJung, Young Soo-
dc.contributor.alternativeNameChoi, Seung Ho-
dc.contributor.affiliatedAuthorKim, Ki Jun-
dc.contributor.affiliatedAuthorShin, Yang Sik-
dc.contributor.affiliatedAuthorLee, Sung Jin-
dc.contributor.affiliatedAuthorJung, Young Soo-
dc.contributor.affiliatedAuthorChoi, Seung Ho-
dc.rights.accessRightsnot free-
dc.citation.volume66-
dc.citation.number10-
dc.citation.startPage2104-
dc.citation.endPage2109-
dc.identifier.bibliographicCitationJournal of Oral and Maxillofacial Surgery, Vol.66(10) : 2104-2109, 2008-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Anesthesiology and Pain Medicine (마취통증의학교실) > 1. Journal Papers
2. College of Dentistry (치과대학) > Dept. of Oral and Maxillofacial Surgery (구강악안면외과학교실) > 1. Journal Papers

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