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뇌허혈 손상시 아그마틴이 기질분해효소의 발현에 미치는 영향

Other Titles
 The Effect of Agmatine on Expression of MMP2 and MMP9 in Cerebral Ischemia 
Authors
 김재환  ;  이용우  ;  김재영  ;  이원택  ;  박경아  ;  이종은 
Citation
 Korean Journal of Anatomy (대한해부학회지), Vol.41(1) : 97-104, 2008 
Journal Title
Korean Journal of Anatomy(대한해부학회지)
ISSN
 1225-1305 
Issue Date
2008
Keywords
Agmatine ; Cerebral ischemia ; MMP2 ; MMP9 ; Nitric oxide
Abstract
Agmatine is a primary amine formed by decarboxylation of L-arginine synthesized in the mammalian brain. Recent studies have shown that agmatine is neuroprotective in models of trauma and ischemia. The purpose of this study was to evaluate the effect of agmatine on the expression of MMP2 and MMP9, which are expressed in reperfusion injury following cerebral ischemia. Mice were subjected to 2 h middle cerebral artery occlusion and 22 h reperfusion. Agmatine (100 mg/kg) was administered intraperitoneally at the start of reperfusion. Agmatine treatment significantly reduced the immunoreactivity of MMP2 and MMP9 in the cortex, striatum, and penumbra on the ipsilateral side. The immunoreactivity of MMP2 and MMP9 was markedly lower in blood vessels of the agmatine-treated group than in the experimental control group. Immunoblot analysis showed that agmatine treatment decreased the expression of MMP2 and MMP9. After exogenous agmatine administration, the expression of agmatine was higher in the striatum and penumbra of the agmatine-treated group than in the experimental control group. The fluorescence intensity was markedly greater in blood vessels in the agmatine-treated group than in the experimental control group. These data suggest that agmatine might decrease the expression of MMP2 and MMP9 by regulating NOS activity, and thereby modulating NO synthesis.
Full Text
http://scholar.dkyobobook.co.kr/searchDetail.laf?barcode=4010022945700
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Anatomy (해부학교실) > 1. Journal Papers
Yonsei Authors
Kim, Jae Hwan(김재환)
Park, Kyung Ah(박경아)
Lee, Won Taek(이원택) ORCID logo https://orcid.org/0000-0001-7348-9562
Lee, Jong Eun(이종은) ORCID logo https://orcid.org/0000-0001-6203-7413
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/107355
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