Randomized controlled trial comparing gastrectomy plus chemotherapy with chemotherapy alone in advanced gastric cancer with a single non-curable factor: Japan Clinical Oncology Group Study JCOG 0705 and Korea Gastric Cancer Association Study KGCA01

Kazumasa Fujitani; Han-Kwang Yang; Yukinori Kurokawa; Do Joong Park; Toshimasa Tsujinaka; Byung-Joo Park; Haruhiko Fukuda; Sung Hoon Noh; Narikazu Boku; Yung-Jue Bang; Mitsuru Sasako; Jong-Inn Lee

doi:10.1093/jjco/hyn058

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Randomized controlled trial comparing gastrectomy plus chemotherapy with chemotherapy alone in advanced gastric cancer with a single non-curable factor: Japan Clinical Oncology Group Study JCOG 0705 and Korea Gastric Cancer Association Study KGCA01

Authors: Kazumasa Fujitani ; Han-Kwang Yang ; Yukinori Kurokawa ; Do Joong Park ; Toshimasa Tsujinaka ; Byung-Joo Park ; Haruhiko Fukuda ; Sung Hoon Noh ; Narikazu Boku ; Yung-Jue Bang ; Mitsuru Sasako ; Jong-Inn Lee

Citation: JAPANESE JOURNAL OF CLINICAL ONCOLOGY, Vol.38(7) : 504-506, 2008

Journal Title: JAPANESE JOURNAL OF CLINICAL ONCOLOGY

ISSN: 0368-2811

Issue Date: 2008

MeSH: Adenocarcinoma/drug therapy* ; Adenocarcinoma/pathology ; Adenocarcinoma/surgery* ; Adult ; Aged ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use* ; Chemotherapy, Adjuvant ; Clinical Protocols ; Gastrectomy* ; Humans ; Japan ; Korea ; Middle Aged ; Patient Selection ; Research Design ; Stomach Neoplasms/drug therapy* ; Stomach Neoplasms/pathology ; Stomach Neoplasms/surgery*

Keywords: Adenocarcinoma/drug therapy* ; Adenocarcinoma/pathology ; Adenocarcinoma/surgery* ; Adult ; Aged ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use* ; Chemotherapy, Adjuvant ; Clinical Protocols ; Gastrectomy* ; Humans ; Japan ; Korea ; Middle Aged ; Patient Selection ; Research Design ; Stomach Neoplasms/drug therapy* ; Stomach Neoplasms/pathology ; Stomach Neoplasms/surgery*

Abstract: A randomized controlled trial has started in both Japan and Korea to evaluate the role of gastrectomy in the management of incurable advanced gastric cancer (AGC). Patients with AGC diagnosed as having a single non-curable factor are randomized to gastrectomy plus chemotherapy or chemotherapy alone. Surgeons at 33 specialized centers in Japan and at 15 high-volume hospitals in Korea will recruit 330 patients. Primary end-point is overall survival, and secondary end-points are progression-free survival and adverse events associated with either gastrectomy or chemotherapy.