Cited 83 times in
Randomized clinical trial of D2 and extended paraaortic lymphadenectomy in patients with gastric cancer.
DC Field | Value | Language |
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dc.contributor.author | 노성훈 | - |
dc.date.accessioned | 2015-05-19T16:58:55Z | - |
dc.date.available | 2015-05-19T16:58:55Z | - |
dc.date.issued | 2008 | - |
dc.identifier.issn | 1341-9625 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/107304 | - |
dc.description.abstract | BACKGROUND: The survival of patients with advanced gastric cancer after D2 dissection is still poor. Asian surgeons have proposed a more radical lymph node dissection, designated as D4 dissection, where paraaortic lymph nodes are removed in combination with D2 dissection. To evaluate the survival benefit of D4 dissection, a multi-institutional randomized trial of D2 vs D4 gastrectomy was conducted. METHODS: Patients enrolled in the study had potentially curable gastric adenocarcinoma at an advanced stage. Patients were randomized to undergo either D2 or D4 gastrectomy. RESULTS: Two hundred and ninety-three patients were registered and 269 patients were eligible; 135 patients were allocated to the D2 group and 134 to the D4 group. Five-year survival was 52.6% after D2 surgery and 55.0% after D4 gastrectomy. There was no significant difference in survival between the D2 and D4 groups (chi(2) = 0.064; P = 0.801). Hospital deaths occurred in 1 patients (0.7%) in the D2 group and 5 in the D4 group D4 gastrectomy is a more risky surgery than D2 dissection. Seven patients (5.2%) in the D2 and 15 (11.2%) in the D4 group died of causes other than gastric cancer recurrence. Sixty-three patients (46.7%) in the D2 group and 52 (38.8%) in the D4 group had disease recurrence. CONCLUSION: Prophylactic D4 dissection is not recommended for patients with potentially curable advanced gastric cancer | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 132~137 | - |
dc.relation.isPartOf | INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adenocarcinoma/mortality | - |
dc.subject.MESH | Adenocarcinoma/pathology | - |
dc.subject.MESH | Adenocarcinoma/surgery* | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Aorta | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Gastrectomy/methods* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Lymph Node Excision/methods* | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Stomach Neoplasms/mortality | - |
dc.subject.MESH | Stomach Neoplasms/pathology | - |
dc.subject.MESH | Stomach Neoplasms/surgery* | - |
dc.subject.MESH | Survival Analysis | - |
dc.title | Randomized clinical trial of D2 and extended paraaortic lymphadenectomy in patients with gastric cancer. | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Surgery (외과학) | - |
dc.contributor.googleauthor | Yutaka Yonemura | - |
dc.contributor.googleauthor | Cheng-Chung Wu | - |
dc.contributor.googleauthor | Norimasa Fukushima | - |
dc.contributor.googleauthor | Ichirou Honda | - |
dc.contributor.googleauthor | Etsurou Bandou | - |
dc.contributor.googleauthor | Taiichi Kawamura | - |
dc.contributor.googleauthor | Tohru Kamata | - |
dc.contributor.googleauthor | Byung-Sik Kim | - |
dc.contributor.googleauthor | Nobuo Matsuki | - |
dc.contributor.googleauthor | Toshiharu Sawa | - |
dc.contributor.googleauthor | Sung-Hoon Noh | - |
dc.identifier.doi | 10.1007/s10147-007-0727-1 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01281 | - |
dc.relation.journalcode | J01097 | - |
dc.identifier.eissn | 1437-7772 | - |
dc.identifier.pmid | 18463957 | - |
dc.identifier.url | http://link.springer.com/article/10.1007%2Fs10147-007-0727-1 | - |
dc.subject.keyword | Gastric cancer | - |
dc.subject.keyword | Gastrectomy | - |
dc.subject.keyword | Lymphadenectomy | - |
dc.subject.keyword | Paraaortic lymph nodes | - |
dc.subject.keyword | D2 dissection | - |
dc.subject.keyword | D4 dissection | - |
dc.contributor.alternativeName | Noh, Sung Hoon | - |
dc.contributor.affiliatedAuthor | Noh, Sung Hoon | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 13 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 132 | - |
dc.citation.endPage | 137 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY, Vol.13(2) : 132-137, 2008 | - |
dc.identifier.rimsid | 48275 | - |
dc.type.rims | ART | - |
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