4 190

Cited 54 times in

Could lipid infusion be a risk for parenteral nutrition-associated cholestasis in low birth weight neonates?

DC FieldValueLanguage
dc.contributor.author신재일-
dc.contributor.author이철-
dc.contributor.author남궁란-
dc.contributor.author박민수-
dc.date.accessioned2015-05-19T16:57:21Z-
dc.date.available2015-05-19T16:57:21Z-
dc.date.issued2008-
dc.identifier.issn0340-6199-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/107255-
dc.description.abstractTo assess whether lipid infusion could be a risk factor for parenteral nutrition-associated cholestasis (PNAC) in low birth weight neonates, 22 newborns with cholestasis (29.8 +/- 1.6 weeks, 1298 +/- 217 g) were compared with 22 without cholestasis (29.5 +/- 1.7 weeks, 1286 +/- 363 g). The mean level of peak direct bilirubin for the cholestasis group was 4.6 mg/dl compared to 1.2 mg/dl for the noncholestasis group. A univariate analysis revealed that PNAC was significantly related to duration of fasting (p = 0.008) and parenteral nutrition (p < 0.0001), days of antibiotics use (p = 0.025), positive C-reactive protein (p = 0.018) or gastric culture (p = 0.018), and feeding intolerance (p < 0.0001). Total amino acid amount (p < 0.0001), total lipid amount (p < 0.0001), and average daily lipid amount (p = 0.002) were significantly higher in the cholestasis group than in the noncholestasis group. Conversely, prenatal administration of dexamethasone was a significant protective factor of PNAC (p = 0.008). Logistic regression analysis revealed that the cumulative amount of lipid infusion was an independent risk factor for PNAC (p = 0.041; OR 1.174; CI 1.007-1.369). We suggest that decreasing the cumulative load of amino acids and intralipids with early trophic feeding, control of infection, and prenatal administration of dexamethasone could possibly attenuate the severity of PNAC-
dc.description.statementOfResponsibilityopen-
dc.format.extent197~202-
dc.relation.isPartOfEUROPEAN JOURNAL OF PEDIATRICS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHCholestasis/etiology*-
dc.subject.MESHEnergy Intake-
dc.subject.MESHHumans-
dc.subject.MESHInfant, Low Birth Weight*-
dc.subject.MESHInfant, Newborn-
dc.subject.MESHInfant, Premature, Diseases/therapy-
dc.subject.MESHInfant, Small for Gestational Age-
dc.subject.MESHLipids/administration & dosage*-
dc.subject.MESHLipids/adverse effects-
dc.subject.MESHLogistic Models-
dc.subject.MESHMultivariate Analysis-
dc.subject.MESHParenteral Nutrition/adverse effects*-
dc.subject.MESHRetrospective Studies-
dc.subject.MESHRisk Factors-
dc.titleCould lipid infusion be a risk for parenteral nutrition-associated cholestasis in low birth weight neonates?-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Pediatrics (소아과학)-
dc.contributor.googleauthorJae Il Shin-
dc.contributor.googleauthorRan Namgung-
dc.contributor.googleauthorMin Soo Park-
dc.contributor.googleauthorChul Lee-
dc.identifier.doi10.1007/s00431-007-0454-7-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA02142-
dc.contributor.localIdA03253-
dc.contributor.localIdA01241-
dc.contributor.localIdA01468-
dc.relation.journalcodeJ00839-
dc.identifier.eissn1432-1076-
dc.identifier.pmid17436017-
dc.identifier.urlhttp://link.springer.com/article/10.1007%2Fs00431-007-0454-7-
dc.subject.keywordTotal parenteral nutrition-
dc.subject.keywordCholestasis-
dc.subject.keywordLow birth weight neonates-
dc.subject.keywordLipid-
dc.contributor.alternativeNameShin, Jae Il-
dc.contributor.alternativeNameLee, Chul-
dc.contributor.alternativeNameNamgung, Ran-
dc.contributor.alternativeNamePark, Min Soo-
dc.contributor.affiliatedAuthorShin, Jae Il-
dc.contributor.affiliatedAuthorLee, Chul-
dc.contributor.affiliatedAuthorNamgung, Ran-
dc.contributor.affiliatedAuthorPark, Min Soo-
dc.rights.accessRightsnot free-
dc.citation.volume167-
dc.citation.number2-
dc.citation.startPage197-
dc.citation.endPage202-
dc.identifier.bibliographicCitationEUROPEAN JOURNAL OF PEDIATRICS, Vol.167(2) : 197-202, 2008-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아청소년과학교실) > 1. Journal Papers

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.