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Overexpression of transforming growth factor-beta 1 in the valvular fibrosis of chronic rheumatic heart disease

DC Field Value Language
dc.contributor.author박한기-
dc.contributor.author장병철-
dc.date.accessioned2015-05-19T16:57:03Z-
dc.date.available2015-05-19T16:57:03Z-
dc.date.issued2008-
dc.identifier.issn1011-8934-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/107245-
dc.description.abstractFor the purpose of determining the pathogenic role of transforming growth factor-beta1 (TGF-beta 1) in the mechanism of chronic rheumatic heart disease, we evaluated the expression of TGF-beta 1, proliferation of myofibroblasts, and changes in extracellular matrix components including collagen and proteoglycan in 30 rheumatic mitral valves and in 15 control valves. High TGF-beta 1 expression was identified in 21 cases (70%) of rheumatic mitral valves, whereas only 3 cases (20%) of the control group showed high TGF-beta 1 expression (p<0.001). Additionally, increased proliferation of myofibroblasts was observed in the rheumatic valves. High TGF-beta1 expression positively correlated with the proliferation of myofibroblasts (p=0.004), valvular fibrosis (p<0.001), inflammatory cell infiltration (p=0.004), neovascularization (p=0.007), and calcification (p<0.001) in the valvular leaflets. The ratio of proteoglycan to collagen deposition inversely correlated with TGF-beta 1 expression in mitral valves (p=0.040). In conclusion, an ongoing inflammatory process, the expression of TGF-beta 1, and proliferation of myofibroblasts within the valves have a potential role in the valvular fibrosis, calcification, and changes in the extracellular matrix that lead to the scarring sequelae of rheumatic heart disease.-
dc.description.statementOfResponsibilityopen-
dc.format.extent41~48-
dc.relation.isPartOfJOURNAL OF KOREAN MEDICAL SCIENCE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHChronic Disease-
dc.subject.MESHCollagen/metabolism-
dc.subject.MESHFemale-
dc.subject.MESHFibrosis-
dc.subject.MESHHumans-
dc.subject.MESHImmunohistochemistry-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHMitral Valve/pathology*-
dc.subject.MESHProteoglycans/metabolism-
dc.subject.MESHRheumatic Heart Disease/metabolism*-
dc.subject.MESHRheumatic Heart Disease/pathology-
dc.subject.MESHTransforming Growth Factor beta1/analysis-
dc.subject.MESHTransforming Growth Factor beta1/physiology*-
dc.titleOverexpression of transforming growth factor-beta 1 in the valvular fibrosis of chronic rheumatic heart disease-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Thoracic & Cardiovascular Surgery (흉부외과학)-
dc.contributor.googleauthorLucia Kim-
dc.contributor.googleauthorDo Kyun Kim-
dc.contributor.googleauthorWoo Ick Yang-
dc.contributor.googleauthorDong Hwan Shin-
dc.contributor.googleauthorIck Mo Jung-
dc.contributor.googleauthorHan Ki Park-
dc.contributor.googleauthorByung Chul Chang-
dc.identifier.doi10.3346/jkms.2008.23.1.41-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA01729-
dc.contributor.localIdA03430-
dc.relation.journalcodeJ01517-
dc.identifier.eissn1598-6357-
dc.identifier.pmid18303197-
dc.subject.keywordRheumatic Heart Disease-
dc.subject.keywordTransforming Growth Factor- 1-
dc.subject.keywordHeart Valves-
dc.subject.keywordFibrosis-
dc.contributor.alternativeNamePark, Han Ki-
dc.contributor.alternativeNameChang, Byung Chul-
dc.contributor.affiliatedAuthorPark, Han Ki-
dc.contributor.affiliatedAuthorChang, Byung Chul-
dc.rights.accessRightsfree-
dc.citation.volume23-
dc.citation.number1-
dc.citation.startPage41-
dc.citation.endPage48-
dc.identifier.bibliographicCitationJOURNAL OF KOREAN MEDICAL SCIENCE, Vol.23(1) : 41-48, 2008-
dc.identifier.rimsid48227-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Thoracic and Cardiovascular Surgery (흉부외과학교실) > 1. Journal Papers

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