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Overexpression of transforming growth factor-beta 1 in the valvular fibrosis of chronic rheumatic heart disease
DC Field | Value | Language |
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dc.contributor.author | 박한기 | - |
dc.contributor.author | 장병철 | - |
dc.date.accessioned | 2015-05-19T16:57:03Z | - |
dc.date.available | 2015-05-19T16:57:03Z | - |
dc.date.issued | 2008 | - |
dc.identifier.issn | 1011-8934 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/107245 | - |
dc.description.abstract | For the purpose of determining the pathogenic role of transforming growth factor-beta1 (TGF-beta 1) in the mechanism of chronic rheumatic heart disease, we evaluated the expression of TGF-beta 1, proliferation of myofibroblasts, and changes in extracellular matrix components including collagen and proteoglycan in 30 rheumatic mitral valves and in 15 control valves. High TGF-beta 1 expression was identified in 21 cases (70%) of rheumatic mitral valves, whereas only 3 cases (20%) of the control group showed high TGF-beta 1 expression (p<0.001). Additionally, increased proliferation of myofibroblasts was observed in the rheumatic valves. High TGF-beta1 expression positively correlated with the proliferation of myofibroblasts (p=0.004), valvular fibrosis (p<0.001), inflammatory cell infiltration (p=0.004), neovascularization (p=0.007), and calcification (p<0.001) in the valvular leaflets. The ratio of proteoglycan to collagen deposition inversely correlated with TGF-beta 1 expression in mitral valves (p=0.040). In conclusion, an ongoing inflammatory process, the expression of TGF-beta 1, and proliferation of myofibroblasts within the valves have a potential role in the valvular fibrosis, calcification, and changes in the extracellular matrix that lead to the scarring sequelae of rheumatic heart disease. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 41~48 | - |
dc.relation.isPartOf | JOURNAL OF KOREAN MEDICAL SCIENCE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Chronic Disease | - |
dc.subject.MESH | Collagen/metabolism | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Fibrosis | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Immunohistochemistry | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Mitral Valve/pathology* | - |
dc.subject.MESH | Proteoglycans/metabolism | - |
dc.subject.MESH | Rheumatic Heart Disease/metabolism* | - |
dc.subject.MESH | Rheumatic Heart Disease/pathology | - |
dc.subject.MESH | Transforming Growth Factor beta1/analysis | - |
dc.subject.MESH | Transforming Growth Factor beta1/physiology* | - |
dc.title | Overexpression of transforming growth factor-beta 1 in the valvular fibrosis of chronic rheumatic heart disease | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Thoracic & Cardiovascular Surgery (흉부외과학) | - |
dc.contributor.googleauthor | Lucia Kim | - |
dc.contributor.googleauthor | Do Kyun Kim | - |
dc.contributor.googleauthor | Woo Ick Yang | - |
dc.contributor.googleauthor | Dong Hwan Shin | - |
dc.contributor.googleauthor | Ick Mo Jung | - |
dc.contributor.googleauthor | Han Ki Park | - |
dc.contributor.googleauthor | Byung Chul Chang | - |
dc.identifier.doi | 10.3346/jkms.2008.23.1.41 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01729 | - |
dc.contributor.localId | A03430 | - |
dc.relation.journalcode | J01517 | - |
dc.identifier.eissn | 1598-6357 | - |
dc.identifier.pmid | 18303197 | - |
dc.subject.keyword | Rheumatic Heart Disease | - |
dc.subject.keyword | Transforming Growth Factor- 1 | - |
dc.subject.keyword | Heart Valves | - |
dc.subject.keyword | Fibrosis | - |
dc.contributor.alternativeName | Park, Han Ki | - |
dc.contributor.alternativeName | Chang, Byung Chul | - |
dc.contributor.affiliatedAuthor | Park, Han Ki | - |
dc.contributor.affiliatedAuthor | Chang, Byung Chul | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 23 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 41 | - |
dc.citation.endPage | 48 | - |
dc.identifier.bibliographicCitation | JOURNAL OF KOREAN MEDICAL SCIENCE, Vol.23(1) : 41-48, 2008 | - |
dc.identifier.rimsid | 48227 | - |
dc.type.rims | ART | - |
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