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Plasmacytoid transitional cell carcinoma of urinary bladder: a clinicopathologic study of 9 cases

DC FieldValueLanguage
dc.contributor.author조남훈-
dc.date.accessioned2015-05-19T16:56:49Z-
dc.date.available2015-05-19T16:56:49Z-
dc.date.issued2008-
dc.identifier.issn0147-5185-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/107238-
dc.description.abstractIn this report, we summarized the clinicopathologic features of 9 cases of plasmacytoid transitional cell carcinoma (TCC) of the urinary bladder, a rare variant of TCC. All 9 patients were men with a mean of age 64.3 years (range, 46 to 81 y). All but 1 patient presented with gross hematuria; the remaining patient had urgency and microscopic hematuria. Cystoscopic findings revealed a dominant solid mass with surrounding multiple papillary lesions in 6 cases and multiple masslike lesions in 3 other cases. The initial diagnosis of plasmacytoid TCC was made on transurethral resection in 8 cases and cystoscopic biopsy in 1. One patient had TNM stage I disease, 2 had stage II disease, 3 had stage III disease, and 3 had stage IV disease. Four patients were treated by radical cystectomy with chemotherapy, 2 by radical cystectomy alone, 1 each by chemotherapy or intravesical bacillus Calmette-Guerin infusion alone, and 1 did not receive any further therapy. Microscopically, all tumors contained plasmacytoid cells, which composed 30% to 100% of the entire tumor. Eight of 9 cases were associated with high-grade TCC, and transitional cell carcinoma in situ was present in 4 cases. The plasmacytoid tumor cells were characterized by eccentrically located nuclei and abundant eosinophilic cytoplasm. Interestingly, plasmacytoid transitional cell carcinoma in situ was noted in 1 case. Immunohistochemical staining demonstrated that both plasmacytoid and conventional TCC components were positive for cytokeratins 7 and 20. The mean Ki-67 labeling index was 30% (range, 10% to 50%), and p53 expression in the majority of cases was low (5% to 10%), except for in 2 cases (70% and 80%). The mean follow-up in 8 patients was 24.5 months (range, 5 to 47 mo); the other patient was lost to follow-up. Five patients died of disease from 5 to 36 months, 2 patients were alive with disease at 30 and 47 months, and 1 patient was alive and well at 36 months with no evidence of disease. In summary, plasmacytoid TCC tends to present at an advanced stage and to have a poor prognosis. Morphologic recognition and distinction from other plasmacytoid malignant neoplasms is critical for its clinical management and immunohistochemical studies may be required for differential diagnosis.-
dc.description.statementOfResponsibilityopen-
dc.format.extent752~757-
dc.relation.isPartOfAMERICAN JOURNAL OF SURGICAL PATHOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAged-
dc.subject.MESHAged, 80 and over-
dc.subject.MESHBiomarkers, Tumor/analysis-
dc.subject.MESHCarcinoma in Situ/pathology-
dc.subject.MESHCarcinoma, Transitional Cell/chemistry-
dc.subject.MESHCarcinoma, Transitional Cell/pathology*-
dc.subject.MESHCarcinoma, Transitional Cell/therapy-
dc.subject.MESHCell Nucleus/pathology-
dc.subject.MESHCombined Modality Therapy-
dc.subject.MESHCystoscopy-
dc.subject.MESHCytoplasm/pathology-
dc.subject.MESHHumans-
dc.subject.MESHImmunohistochemistry-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHNeoplasm Staging-
dc.subject.MESHPlasma Cells/pathology*-
dc.subject.MESHPrognosis-
dc.subject.MESHTreatment Outcome-
dc.subject.MESHUrinary Bladder Neoplasms/chemistry-
dc.subject.MESHUrinary Bladder Neoplasms/pathology*-
dc.subject.MESHUrinary Bladder Neoplasms/therapy-
dc.titlePlasmacytoid transitional cell carcinoma of urinary bladder: a clinicopathologic study of 9 cases-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Pathology (병리학)-
dc.contributor.googleauthorJae Y. Ro-
dc.contributor.googleauthorSteven S. Shen-
dc.contributor.googleauthorHyang I. Lee-
dc.contributor.googleauthorEun K. Hong-
dc.contributor.googleauthorYoon H. Lee-
dc.contributor.googleauthorNam H. Cho-
dc.contributor.googleauthorSoo J. Jung-
dc.contributor.googleauthorYeong J. Choi-
dc.contributor.googleauthorAlberto G. Ayala-
dc.identifier.doi10.1097/PAS.0b013e318159af9e-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA03812-
dc.relation.journalcodeJ00120-
dc.identifier.eissn1532-0979-
dc.identifier.pmid18379419-
dc.identifier.urlhttp://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&AN=00000478-200805000-00012&LSLINK=80&D=ovft-
dc.subject.keywordplasmacytoid-
dc.subject.keywordtransitional cell carcinoma-
dc.subject.keywordurothelial neoplasm-
dc.subject.keywordvariant-
dc.contributor.alternativeNameCho, Nam Hoon-
dc.contributor.affiliatedAuthorCho, Nam Hoon-
dc.rights.accessRightsnot free-
dc.citation.volume32-
dc.citation.number5-
dc.citation.startPage752-
dc.citation.endPage757-
dc.identifier.bibliographicCitationAMERICAN JOURNAL OF SURGICAL PATHOLOGY, Vol.32(5) : 752-757, 2008-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers

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