Cited 73 times in
Plasmacytoid transitional cell carcinoma of urinary bladder: a clinicopathologic study of 9 cases
DC Field | Value | Language |
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dc.contributor.author | 조남훈 | - |
dc.date.accessioned | 2015-05-19T16:56:49Z | - |
dc.date.available | 2015-05-19T16:56:49Z | - |
dc.date.issued | 2008 | - |
dc.identifier.issn | 0147-5185 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/107238 | - |
dc.description.abstract | In this report, we summarized the clinicopathologic features of 9 cases of plasmacytoid transitional cell carcinoma (TCC) of the urinary bladder, a rare variant of TCC. All 9 patients were men with a mean of age 64.3 years (range, 46 to 81 y). All but 1 patient presented with gross hematuria; the remaining patient had urgency and microscopic hematuria. Cystoscopic findings revealed a dominant solid mass with surrounding multiple papillary lesions in 6 cases and multiple masslike lesions in 3 other cases. The initial diagnosis of plasmacytoid TCC was made on transurethral resection in 8 cases and cystoscopic biopsy in 1. One patient had TNM stage I disease, 2 had stage II disease, 3 had stage III disease, and 3 had stage IV disease. Four patients were treated by radical cystectomy with chemotherapy, 2 by radical cystectomy alone, 1 each by chemotherapy or intravesical bacillus Calmette-Guerin infusion alone, and 1 did not receive any further therapy. Microscopically, all tumors contained plasmacytoid cells, which composed 30% to 100% of the entire tumor. Eight of 9 cases were associated with high-grade TCC, and transitional cell carcinoma in situ was present in 4 cases. The plasmacytoid tumor cells were characterized by eccentrically located nuclei and abundant eosinophilic cytoplasm. Interestingly, plasmacytoid transitional cell carcinoma in situ was noted in 1 case. Immunohistochemical staining demonstrated that both plasmacytoid and conventional TCC components were positive for cytokeratins 7 and 20. The mean Ki-67 labeling index was 30% (range, 10% to 50%), and p53 expression in the majority of cases was low (5% to 10%), except for in 2 cases (70% and 80%). The mean follow-up in 8 patients was 24.5 months (range, 5 to 47 mo); the other patient was lost to follow-up. Five patients died of disease from 5 to 36 months, 2 patients were alive with disease at 30 and 47 months, and 1 patient was alive and well at 36 months with no evidence of disease. In summary, plasmacytoid TCC tends to present at an advanced stage and to have a poor prognosis. Morphologic recognition and distinction from other plasmacytoid malignant neoplasms is critical for its clinical management and immunohistochemical studies may be required for differential diagnosis. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 752~757 | - |
dc.relation.isPartOf | AMERICAN JOURNAL OF SURGICAL PATHOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Aged, 80 and over | - |
dc.subject.MESH | Biomarkers, Tumor/analysis | - |
dc.subject.MESH | Carcinoma in Situ/pathology | - |
dc.subject.MESH | Carcinoma, Transitional Cell/chemistry | - |
dc.subject.MESH | Carcinoma, Transitional Cell/pathology* | - |
dc.subject.MESH | Carcinoma, Transitional Cell/therapy | - |
dc.subject.MESH | Cell Nucleus/pathology | - |
dc.subject.MESH | Combined Modality Therapy | - |
dc.subject.MESH | Cystoscopy | - |
dc.subject.MESH | Cytoplasm/pathology | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Immunohistochemistry | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Neoplasm Staging | - |
dc.subject.MESH | Plasma Cells/pathology* | - |
dc.subject.MESH | Prognosis | - |
dc.subject.MESH | Treatment Outcome | - |
dc.subject.MESH | Urinary Bladder Neoplasms/chemistry | - |
dc.subject.MESH | Urinary Bladder Neoplasms/pathology* | - |
dc.subject.MESH | Urinary Bladder Neoplasms/therapy | - |
dc.title | Plasmacytoid transitional cell carcinoma of urinary bladder: a clinicopathologic study of 9 cases | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pathology (병리학) | - |
dc.contributor.googleauthor | Jae Y. Ro | - |
dc.contributor.googleauthor | Steven S. Shen | - |
dc.contributor.googleauthor | Hyang I. Lee | - |
dc.contributor.googleauthor | Eun K. Hong | - |
dc.contributor.googleauthor | Yoon H. Lee | - |
dc.contributor.googleauthor | Nam H. Cho | - |
dc.contributor.googleauthor | Soo J. Jung | - |
dc.contributor.googleauthor | Yeong J. Choi | - |
dc.contributor.googleauthor | Alberto G. Ayala | - |
dc.identifier.doi | 10.1097/PAS.0b013e318159af9e | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A03812 | - |
dc.relation.journalcode | J00120 | - |
dc.identifier.eissn | 1532-0979 | - |
dc.identifier.pmid | 18379419 | - |
dc.identifier.url | http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&AN=00000478-200805000-00012&LSLINK=80&D=ovft | - |
dc.subject.keyword | plasmacytoid | - |
dc.subject.keyword | transitional cell carcinoma | - |
dc.subject.keyword | urothelial neoplasm | - |
dc.subject.keyword | variant | - |
dc.contributor.alternativeName | Cho, Nam Hoon | - |
dc.contributor.affiliatedAuthor | Cho, Nam Hoon | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 32 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 752 | - |
dc.citation.endPage | 757 | - |
dc.identifier.bibliographicCitation | AMERICAN JOURNAL OF SURGICAL PATHOLOGY, Vol.32(5) : 752-757, 2008 | - |
dc.identifier.rimsid | 47839 | - |
dc.type.rims | ART | - |
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