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Aberrant promoter CpG islands methylation of tumor suppressor genes in cholangiocarcinoma
DC Field | Value | Language |
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dc.contributor.author | 박영년 | - |
dc.date.accessioned | 2015-05-19T16:56:22Z | - |
dc.date.available | 2015-05-19T16:56:22Z | - |
dc.date.issued | 2008 | - |
dc.identifier.issn | 0965-0407 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/107224 | - |
dc.description.abstract | Aberrant DNA methylation of 5'-CpG islands located within gene promoters has been identified as a mechanism for transcriptional inactivation of tumor suppressor genes. To ascertain the mechanism of gene promoter hypermethylation in cholangiocarcinoma (CC), we investigated promoter methylation status of the candidate genes ID4, DLC-1, and SFRP1 in 41 CCs, 19 adjacent nontumor tissues, and 15 normal liver tissues using methylation-specific PCR (MSP). The frequencies of DNA methylation were: 57.5% (23 of 40) for ID4, 14.3% (5 of 35) for DLC-1, and 63.4% (26 of 41) for SFRP1, respectively. In contrast, a low frequency of methylation was detected in nontumor tissues. In addition, hypermethylated status of these genes was detected in three kinds of CC cell lines. Moreover, the downregulated expression of these genes in these cells was restored by treatment with 5-aza-2'-deoxycytidine, a DNA methyltransferase inhibitor. Taken together, these results suggest that aberrant DNA methylation may contribute to the tumorigenesis of cholangiocarcinoma | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 151~157 | - |
dc.relation.isPartOf | ONCOLOGY RESEARCH | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Bile Duct Neoplasms/genetics* | - |
dc.subject.MESH | Bile Duct Neoplasms/pathology | - |
dc.subject.MESH | Bile Ducts, Intrahepatic* | - |
dc.subject.MESH | Cell Line, Tumor | - |
dc.subject.MESH | Cholangiocarcinoma/genetics* | - |
dc.subject.MESH | Cholangiocarcinoma/pathology | - |
dc.subject.MESH | CpG Islands* | - |
dc.subject.MESH | DNA Methylation* | - |
dc.subject.MESH | Epigenesis, Genetic | - |
dc.subject.MESH | Genes, Tumor Suppressor* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Promoter Regions, Genetic* | - |
dc.title | Aberrant promoter CpG islands methylation of tumor suppressor genes in cholangiocarcinoma | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pathology (병리학) | - |
dc.contributor.googleauthor | Uhm,Kyung-Ok | - |
dc.contributor.googleauthor | Lee,Eun Soo | - |
dc.contributor.googleauthor | Lee,Yun Mi | - |
dc.contributor.googleauthor | Kim,Hyeon Soo | - |
dc.contributor.googleauthor | Park,Young-Nyun | - |
dc.contributor.googleauthor | Park,Sun-Hwa | - |
dc.identifier.doi | 18773859 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01563 | - |
dc.relation.journalcode | J02420 | - |
dc.identifier.eissn | 1555-3906 | - |
dc.identifier.pmid | 18773859 | - |
dc.identifier.url | http://www.ingentaconnect.com/content/cog/or/2008/00000017/00000004/art00001 | - |
dc.subject.keyword | Adult | - |
dc.subject.keyword | Aged | - |
dc.subject.keyword | Bile Duct Neoplasms/genetics* | - |
dc.subject.keyword | Bile Duct Neoplasms/pathology | - |
dc.subject.keyword | Bile Ducts, Intrahepatic* | - |
dc.subject.keyword | Cell Line, Tumor | - |
dc.subject.keyword | Cholangiocarcinoma/genetics* | - |
dc.subject.keyword | Cholangiocarcinoma/pathology | - |
dc.subject.keyword | CpG Islands* | - |
dc.subject.keyword | DNA Methylation* | - |
dc.subject.keyword | Epigenesis, Genetic | - |
dc.subject.keyword | Genes, Tumor Suppressor* | - |
dc.subject.keyword | Humans | - |
dc.subject.keyword | Middle Aged | - |
dc.subject.keyword | Promoter Regions, Genetic* | - |
dc.contributor.alternativeName | Park, Young Nyun | - |
dc.contributor.affiliatedAuthor | Park, Young Nyun | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 17 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 151 | - |
dc.citation.endPage | 157 | - |
dc.identifier.bibliographicCitation | ONCOLOGY RESEARCH, Vol.17(4) : 151-157, 2008 | - |
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