Cited 43 times in
Selective repression of YKL-40 by NF-kappaB in glioma cell lines involves recruitment of histone deacetylase-1 and -2
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김세훈 | - |
dc.date.accessioned | 2015-05-19T16:56:05Z | - |
dc.date.available | 2015-05-19T16:56:05Z | - |
dc.date.issued | 2008 | - |
dc.identifier.issn | 0014-5793 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/107215 | - |
dc.description.abstract | Here we show that in contrast to other cancer types, tumor necrosis factor (TNF)-alpha suppresses YKL-40 expression in glioma cell lines in a nuclear factor kappaB (NF-kappaB) dependent manner. Even though TNF-alpha causes recruitment of p65 and p50 subunits of NF-kappaB to the YKL-40 promoter in all cell types, recruitment of histone deacetylases (HDAC)-1 and -2, and a consequent deacetylation of histone H3 at the YKL-40 promoter occurs only in glioma cells. Importantly, using chromatin immunoprecipitation assays in frozen glioblastoma multiforme tissues, we show that YKL-40 levels decrease consistent with HDAC1 recruitment despite high levels of nuclear p-p65. This study presents a paradigm for NF-kappaB regulation of one of its targets in a strict cell type specific manner. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 3193~3200 | - |
dc.relation.isPartOf | FEBS LETTERS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Acetylation | - |
dc.subject.MESH | Adipokines | - |
dc.subject.MESH | Cell Line, Tumor | - |
dc.subject.MESH | Chitinase-3-Like Protein 1 | - |
dc.subject.MESH | Chromatin Immunoprecipitation | - |
dc.subject.MESH | Down-Regulation | - |
dc.subject.MESH | Gene Expression Regulation, Neoplastic* | - |
dc.subject.MESH | Glioma/genetics | - |
dc.subject.MESH | Glioma/metabolism* | - |
dc.subject.MESH | Glycoproteins/genetics* | - |
dc.subject.MESH | Histone Deacetylase 1 | - |
dc.subject.MESH | Histone Deacetylase 2 | - |
dc.subject.MESH | Histone Deacetylases/metabolism* | - |
dc.subject.MESH | Histones/metabolism | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Lectins | - |
dc.subject.MESH | NF-kappa B/metabolism* | - |
dc.subject.MESH | NF-kappa B p50 Subunit/metabolism | - |
dc.subject.MESH | Promoter Regions, Genetic | - |
dc.subject.MESH | Repressor Proteins/metabolism* | - |
dc.subject.MESH | Transcription Factor RelA/metabolism | - |
dc.subject.MESH | Tumor Necrosis Factor-alpha/pharmacology | - |
dc.subject.MESH | Tumor Necrosis Factor-alpha/physiology | - |
dc.title | Selective repression of YKL-40 by NF-kappaB in glioma cell lines involves recruitment of histone deacetylase-1 and -2 | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pathology (병리학) | - |
dc.contributor.googleauthor | Krishna P. Bhat | - |
dc.contributor.googleauthor | Christopher E. Pelloski | - |
dc.contributor.googleauthor | Yujian Zhang | - |
dc.contributor.googleauthor | Se Hoon Kim | - |
dc.contributor.googleauthor | Clarissa deLaCruz | - |
dc.contributor.googleauthor | Michael Rehli | - |
dc.contributor.googleauthor | Kenneth D. Aldape | - |
dc.identifier.doi | 10.1016/j.febslet.2008.08.010 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00610 | - |
dc.relation.journalcode | J00890 | - |
dc.identifier.eissn | 1873-3468 | - |
dc.identifier.pmid | 18708058 | - |
dc.subject.keyword | YKL-40 | - |
dc.subject.keyword | NF-jB | - |
dc.subject.keyword | Glioma | - |
dc.subject.keyword | HDAC | - |
dc.contributor.alternativeName | Kim, Se Hoon | - |
dc.contributor.affiliatedAuthor | Kim, Se Hoon | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 582 | - |
dc.citation.number | 21-22 | - |
dc.citation.startPage | 3193 | - |
dc.citation.endPage | 3200 | - |
dc.identifier.bibliographicCitation | FEBS LETTERS, Vol.582(21-22) : 3193-3200, 2008 | - |
dc.identifier.rimsid | 47820 | - |
dc.type.rims | ART | - |
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