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Dexamethasone increases angiopoietin-1 and quiescent hematopoietic stem cells: a novel mechanism of dexamethasone-induced hematoprotection

Authors
 Hyongbum Kim  ;  Ji-Young Choi  ;  Jung Min Lee  ;  Yoon Shin Park  ;  Hwal Suh  ;  Hae-Ryong Song  ;  Sangmee Ahn Jo  ;  Inho Jo 
Citation
 FEBS LETTERS, Vol.582(23-24) : 3509-3514, 2008 
Journal Title
 FEBS LETTERS 
ISSN
 0014-5793 
Issue Date
2008
MeSH
Angiopoietin-1/biosynthesis* ; Angiopoietin-1/genetics ; Animals ; Base Sequence ; Bone Marrow/drug effects ; Bone Marrow/metabolism ; Cytoprotection* ; Dexamethasone/pharmacology* ; Glucocorticoids/pharmacology* ; Humans ; Mice ; Mice, Inbred C57BL ; Myeloid Progenitor Cells/cytology ; Myeloid Progenitor Cells/drug effects* ; Myeloid Progenitor Cells/metabolism ; RNA Stability/drug effects ; RNA, Messenger/biosynthesis ; Receptors, Glucocorticoid/biosynthesis ; Receptors, Glucocorticoid/genetics ; Response Elements
Keywords
Dexamethasone ; Hematopoietic stem cells ; Angiopoietin-1 ; Hematoprotection ; Bone ; marrow
Abstract
Angiopoietin-1 (Ang-1) is known to have hematoprotective effects by increasing the quiescence of hematopoietic stem cells. However, it remains to be determined if the upregulation of Ang-1 and the subsequent increase in the quiescence of hematopoietic stem cells are also involved in the dexamethasone (Dex)-mediated bone marrow protection. Here Western blotting and flow cytometric analyses demonstrate that Dex increases the levels of Ang-1 in mouse bone marrow and the quiescence of hematopoietic stem cells. Our data for the first time suggest that the increased quiescence of hematopoietic stem cells provides a novel mechanism of Dex-induced hematoprotection
Files in This Item:
T200800935.pdf Download
DOI
10.1016/j.febslet.2008.09.021
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Medical Engineering (의학공학교실) > 1. Journal Papers
Yonsei Authors
Suh, Hwal(서활)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/107206
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