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Predictive value of liver cell dysplasia for development of hepatocellular carcinoma in patients with chronic hepatitis B

DC Field Value Language
dc.contributor.author박영년-
dc.contributor.author박찬일-
dc.contributor.author안상훈-
dc.contributor.author전재윤-
dc.contributor.author한광협-
dc.contributor.author구자승-
dc.contributor.author박병규-
dc.date.accessioned2015-05-19T16:55:32Z-
dc.date.available2015-05-19T16:55:32Z-
dc.date.issued2008-
dc.identifier.issn0192-0790-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/107198-
dc.description.abstractGOALS: We aimed to determine whether the presence of large liver cell dysplasia (LLCD) and/or small LCD (SLCD) in chronic hepatitis B is a risk factor for hepatocellular carcinoma (HCC) development. BACKGROUND: A close relationship between LLCD/SLCD and hepatitis B virus has been observed and SLCD has been proposed to be a putative precursor of HCC, whereas the significance of LLCD is still controversial. STUDY: One hundred eighty-one patients with chronic hepatitis B who underwent needle liver biopsy were evaluated for the presence of LLCD/SLCD. The predictive value of LLCD/SLCD for HCC development was assessed. RESULTS: LLCD and SLCD were present at initial biopsy in 82 (45%) and 17 (9%) patients, respectively. During the mean follow-up of 115+/-48 months, 19 (10%) cases were diagnosed of HCC, of which 13 (76%) and 3 (17%) cases had demonstrated LLCD and SLCD, respectively, at initial evaluation. The patients with LLCD showed a significantly higher cumulative probability of HCC development than those without LLCD (P=0.016). The risk of HCC development in the presence of LLCD was approximately 3-fold, with positive and negative predictive values of 15.9% and 94.9%, respectively. The patients with SLCD showed no significant difference in cumulative probability of HCC development compared with those without (P>0.05). CONCLUSIONS: LLCD in chronic hepatitis B is considered to be one of the risk factors for HCC development and its presence may help to identify a high-risk subgroup of patients requiring more intensive screening for HCC.-
dc.description.statementOfResponsibilityopen-
dc.format.extent738~743-
dc.relation.isPartOfJOURNAL OF CLINICAL GASTROENTEROLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHBiopsy, Needle-
dc.subject.MESHCarcinoma, Hepatocellular/diagnosis*-
dc.subject.MESHCarcinoma, Hepatocellular/etiology-
dc.subject.MESHFemale-
dc.subject.MESHFollow-Up Studies-
dc.subject.MESHHepatitis B, Chronic/complications*-
dc.subject.MESHHepatocytes/pathology*-
dc.subject.MESHHumans-
dc.subject.MESHLiver Neoplasms/diagnosis*-
dc.subject.MESHLiver Neoplasms/etiology-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHPredictive Value of Tests-
dc.subject.MESHRisk Factors-
dc.titlePredictive value of liver cell dysplasia for development of hepatocellular carcinoma in patients with chronic hepatitis B-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학)-
dc.contributor.googleauthorJa Seung Koo-
dc.contributor.googleauthorHaeryoung Kim-
dc.contributor.googleauthorByung Kyu Park-
dc.contributor.googleauthorSang Hoon Ahn-
dc.contributor.googleauthorKwang-Hyub Han-
dc.contributor.googleauthorChae Yoon Chon-
dc.contributor.googleauthorChanil Park-
dc.contributor.googleauthorYoung Nyun Park-
dc.identifier.doi10.1097/MCG.0b013e318038159d-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA01563-
dc.contributor.localIdA01710-
dc.contributor.localIdA02226-
dc.contributor.localIdA04268-
dc.contributor.localIdA00198-
dc.contributor.localIdA01473-
dc.contributor.localIdA03544-
dc.relation.journalcodeJ01319-
dc.identifier.eissn1539-2031-
dc.identifier.pmid18277883-
dc.identifier.urlhttp://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&AN=00004836-200807000-00016&LSLINK=80&D=ovft-
dc.subject.keywordliver cell dysplasia-
dc.subject.keywordhepatitis B virus-
dc.subject.keywordhepatocellular carcinoma-
dc.contributor.alternativeNamePark, Young Nyun-
dc.contributor.alternativeNamePark, Chan Il-
dc.contributor.alternativeNameAhn, Sang Hoon-
dc.contributor.alternativeNameChon, Chae Yoon-
dc.contributor.alternativeNameHan, Kwang Hyup-
dc.contributor.alternativeNameKoo, Ja Seung-
dc.contributor.alternativeNamePark, Byung Kyu-
dc.contributor.affiliatedAuthorPark, Young Nyun-
dc.contributor.affiliatedAuthorPark, Chan Il-
dc.contributor.affiliatedAuthorAhn, Sang Hoon-
dc.contributor.affiliatedAuthorHan, Kwang Hyup-
dc.contributor.affiliatedAuthorKoo, Ja Seung-
dc.contributor.affiliatedAuthorPark, Byung Kyu-
dc.contributor.affiliatedAuthorChon, Chae Yoon-
dc.contributor.affiliatedAuthor구자승-
dc.rights.accessRightsnot free-
dc.citation.volume42-
dc.citation.number6-
dc.citation.startPage738-
dc.citation.endPage743-
dc.identifier.bibliographicCitationJOURNAL OF CLINICAL GASTROENTEROLOGY, Vol.42(6) : 738-743, 2008-
dc.identifier.rimsid46564-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers

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