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HoxD10 gene delivery using adenovirus/adeno-associate hybrid virus inhibits the proliferation and tumorigenicity of GH4 pituitary lactotrope tumor cells.

DC FieldValueLanguage
dc.contributor.author이은직-
dc.date.accessioned2015-05-19T16:55:04Z-
dc.date.available2015-05-19T16:55:04Z-
dc.date.issued2008-
dc.identifier.issn0006-291X-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/107183-
dc.description.abstractProlactinoma is one of the most common types of pituitary adenoma. It has been reported that a variety of growth factors and cytokines regulating cell growth and angiogenesis play an important role in the growth of prolactinoma. HoxD10 has been shown to impair endothelial cell migration, block angiogenesis, and maintain a differentiated phenotype of cells. We investigated whether HoxD10 gene delivery could inhibit the growth of prolactinoma. Rat GH4 lactotrope tumor cells were infected with adenovirus/adeno-associated virus (Ad/AAV) hybrid vectors carrying the mouse HoxD10 gene (Hyb-HoxD10) or the beta-galactosidase gene (Hyb-Gal). Hyb-HoxD10 expression inhibited GH4 cell proliferation in vitro. The expression of FGF-2 and cyclin D2 was inhibited in GH4 cells infected with Hyb-HoxD10. GH4 cells transduced with Hyb-HoxD10 did not form tumors in nude mice. These results indicate that the delivery of HoxD10 could potentially inhibit the growth of PRL-secreting tumors. This approach may be a useful tool for targeted therapy of prolactinoma and other neoplasms.-
dc.description.statementOfResponsibilityopen-
dc.format.extent371~374-
dc.relation.isPartOfBIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdenoviridae/genetics-
dc.subject.MESHAnimals-
dc.subject.MESHCell Proliferation-
dc.subject.MESHCyclin D2-
dc.subject.MESHCyclins/metabolism-
dc.subject.MESHDependovirus/genetics-
dc.subject.MESHFibroblast Growth Factor 2/metabolism-
dc.subject.MESHGene Transfer Techniques*-
dc.subject.MESHGenetic Therapy*-
dc.subject.MESHGenetic Vectors*-
dc.subject.MESHHomeodomain Proteins/genetics*-
dc.subject.MESHMice-
dc.subject.MESHPituitary Neoplasms/therapy*-
dc.subject.MESHProlactinoma/therapy*-
dc.subject.MESHRats-
dc.subject.MESHTranscription Factors/genetics*-
dc.subject.MESHbeta-Galactosidase/genetics-
dc.titleHoxD10 gene delivery using adenovirus/adeno-associate hybrid virus inhibits the proliferation and tumorigenicity of GH4 pituitary lactotrope tumor cells.-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학)-
dc.contributor.googleauthorMi Ae Cho-
dc.contributor.googleauthorParham Yashar-
dc.contributor.googleauthorSuk Kyoung Kim-
dc.contributor.googleauthorTaewoong Noh-
dc.contributor.googleauthorMary P. Gillam-
dc.contributor.googleauthorEun Jig Lee-
dc.contributor.googleauthorJ. Larry Jameson-
dc.identifier.doi10.1016/j.bbrc.2008.04.085-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA03050-
dc.relation.journalcodeJ00281-
dc.identifier.eissn1090-2104-
dc.identifier.pmid18442473-
dc.identifier.urlhttp://www.sciencedirect.com/science/article/pii/S0006291X08007316-
dc.subject.keywordHoxD10-
dc.subject.keywordGH4 lactotrope tumor-
dc.subject.keywordFibroblast growth factor 2-
dc.subject.keywordAngiogenesis-
dc.subject.keywordCyclin D2-
dc.subject.keywordAdenovirus/adeno-associate virus hybrid vector-
dc.contributor.alternativeNameLee, Eun Jig-
dc.contributor.affiliatedAuthorLee, Eun Jig-
dc.rights.accessRightsnot free-
dc.citation.volume371-
dc.citation.number3-
dc.citation.startPage371-
dc.citation.endPage374-
dc.identifier.bibliographicCitationBIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Vol.371(3) : 371-374, 2008-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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