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Surface modification for enhancing behaviors of vascular endothelial cells onto polyurethane films by microwave-induced argon plasma

Authors
 Hye Ryeon Lim  ;  Hyun Sook Baek  ;  Mi Hee Lee  ;  Yeon I Woo  ;  Dong-Wook Han  ;  Man Hyeop Han  ;  Hong Koo Baik  ;  Won Sup Choi  ;  Ki Dong Park  ;  Kie-Hyung Chung  ;  Jong-Chul Park 
Citation
 SURFACE & COATINGS TECHNOLOGY, Vol.202(22-23) : 5768-5772, 2008 
Journal Title
 SURFACE & COATINGS TECHNOLOGY 
ISSN
 0257-8972 
Issue Date
2008
Keywords
PolyurethanesEndothelial cellsMicrowave-induced argon plasmaSurface modificationHemocompatibilityTissue engineering
Abstract
Polyurethanes (PUs) are widely used in cardiovascular and other biomedical applications due to their good biocompatibility as well as mechanical properties. However, PUs are poor substrates in supporting the adhesion and growth of vascular endothelial cells. In this study, the surface of PU films was modified by microwave-induced argon plasma treatment in order to improve the hemocompatibility of the films used as cardiovascular prostheses including vascular grafts and stents. The modified surface of PU films was characterized by water contact angle measurement, atomic force microscopy and scanning electron microscopy. Plasma treatment resulted in an appreciable increase in the surface roughness of PU films with a concomitant decrease in the contact angle of the films, suggesting that the hydrophilicity of the film surface might be subsequently enhanced. Furthermore, the cellular behaviors of human umbilical vascular endothelial cells, such as attachment, growth and proliferation, were significantly increased onto the surface-modified PU films. In conclusion, the surface modification of PU films by microwave-induced plasma could enhance the behaviors of endothelial cells and the method would be usefully applied to cardiovascular tissue engineering.
Full Text
http://www.sciencedirect.com/science/article/pii/S0257897208005525
DOI
10.1016/j.surfcoat.2008.06.115
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Medical Engineering (의학공학교실) > 1. Journal Papers
Yonsei Authors
Park, Jong Chul(박종철) ORCID logo https://orcid.org/0000-0003-0083-5991
Baek, Hyun Sook(백현숙)
Woo, Yeon I.(우연이)
Lee, Mi Hee(이미희) ORCID logo https://orcid.org/0000-0002-9630-7044
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/107108
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