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Pregabalin and gabapentin inhibit substance P-induced NF-kappaB activation in neuroblastoma and glioma cells

Authors
 Seyeon Park  ;  Eun Sook Ahn  ;  Dong Woo Han  ;  Jong Hwa Lee  ;  Kyung Tae Min  ;  Hyunkyung Kim  ;  Yong-Woo Hong 
Citation
 JOURNAL OF CELLULAR BIOCHEMISTRY, Vol.105(2) : 414-423, 2008 
Journal Title
 JOURNAL OF CELLULAR BIOCHEMISTRY 
ISSN
 0730-2312 
Issue Date
2008
MeSH
Amines/pharmacology* ; Animals ; Cell Line, Tumor ; Cyclohexanecarboxylic Acids/pharmacology* ; Ganglia, Spinal/pathology ; Glioma/metabolism ; Glioma/pathology* ; Humans ; Inflammation/drug therapy ; NF-kappa B/antagonists & inhibitors* ; NF-kappa B/metabolism ; Neuroblastoma/metabolism ; Neuroblastoma/pathology* ; Pregabalin ; Rats ; Rats, Sprague-Dawley ; Signal Transduction ; Substance P/pharmacology* ; gamma-Aminobutyric Acid/analogs & derivatives* ; gamma-Aminobutyric Acid/pharmacology
Keywords
PREGABALIN ; GABAPENTIN ; SUBSTANCE P ; NF-KB ; NEUROBLASTOMA ; GLIOMA
Abstract
Pregabalin and gabapentin are lipophilic amino acid derivatives of gamma-amino butyric acid that show anticonvulsant and analgesic activity against neuropathic pain. In this study, we investigated their actions on substance P-induced NF-kappaB activation in human neuroblastoma and rat glioma cells. Pregabalin and gabapentin decreased substance P-induced NF-kappaB activation in these cells. These drugs also inhibited NF-kappaB activation in rat spinal dorsal root ganglia cells pre-treated in vitro with substance P. These results suggest a previously undefined role of pregabalin and gabapentin in the regulation of inflammation-related intracellular signaling in both neuronal and glial cells.
Full Text
http://dx.doi.org/10.1002/jcb.21837
DOI
10.1002/jcb.21837
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Anesthesiology and Pain Medicine (마취통증의학교실) > 1. Journal Papers
Yonsei Authors
Min, Kyeong Tae(민경태) ORCID logo https://orcid.org/0000-0002-3299-4500
Lee, Jong Wha(이종화)
Han, Dong Woo(한동우) ORCID logo https://orcid.org/0000-0002-8757-663X
Hong, Yong Woo(홍용우)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/107098
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