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Transfusion-associated iron overload as a predictive factor for poor stem cell mobilization in patients with haematological malignancies

DC FieldValueLanguage
dc.contributor.author정주원-
dc.contributor.author김유리-
dc.contributor.author김진석-
dc.contributor.author민유홍-
dc.contributor.author박인혜-
dc.contributor.author송재우-
dc.date.accessioned2015-05-19T16:50:58Z-
dc.date.available2015-05-19T16:50:58Z-
dc.date.issued2008-
dc.identifier.issn0958-7578-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/107056-
dc.description.abstractTransfusion-associated iron overload is often observed in patients with haematological malignancies. We analysed the effect of iron overload, indicated by high serum ferritin level, on the mobilization of CD34(+) peripheral blood stem cells (PBSCs). We evaluated the association between the serum ferritin level prior to PBSC collection and the number of CD34(+) cells collected through leukapheresis in 51 patients with various haematological malignancies. Patients with serum ferritin level over 1000 ng mL(-1) were defined as high-ferritin group. Comparing the good (> or =1 x 10(6) per kg CD34(+) cells) and poor (<1 x 10(6) per kg CD34(+) cells) mobilizing groups, there was no difference in disease status, previous chemotherapies and white blood cell count at the first day of apheresis. However, there was a significant difference in the median units of red blood cell transfused between the good and poor mobilizer (2 vs. 8 units; P = 0.012). Serum ferritin level was notably higher in the poor mobilizer (1670 +/- 1320 ng mL(-1)) compared with the good mobilizer (965 +/- 705 ng mL(-1), P = 0.035). The cumulative number of CD34(+) cells per kg collected during the whole procedure was significantly lower in the high-ferritin group (5.5 +/- 4.7 x 10(6) per kg vs. 13.1 +/- 9.1 x 10(6) per kg, P = 0.01). Multivariate analysis revealed that serum ferritin level remained as an independent predictive factor for poor PBSC mobilization. Our study indicated that transfusion-associated iron overload is a predictive factor for poor PBSC mobilization. Iron chelation therapy prior to apheresis may be required to collect sufficient numbers of PBSCs in the iron overload patients.-
dc.description.statementOfResponsibilityopen-
dc.format.extent97~103-
dc.relation.isPartOfTRANSFUSION MEDICINE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdolescent-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHAntigens, CD34/blood-
dc.subject.MESHFlow Cytometry-
dc.subject.MESHHematologic Neoplasms/blood*-
dc.subject.MESHHematopoietic Stem Cell Mobilization/methods*-
dc.subject.MESHHumans-
dc.subject.MESHIron Overload/etiology*-
dc.subject.MESHLeukapheresis-
dc.subject.MESHMiddle Aged-
dc.subject.MESHPatient Selection-
dc.subject.MESHPredictive Value of Tests-
dc.subject.MESHRetrospective Studies-
dc.subject.MESHTransfusion Reaction*-
dc.subject.MESHTreatment Outcome-
dc.titleTransfusion-associated iron overload as a predictive factor for poor stem cell mobilization in patients with haematological malignancies-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학)-
dc.contributor.googleauthorI. H. Park-
dc.contributor.googleauthorY. Kim-
dc.contributor.googleauthorJ. S. Kim-
dc.contributor.googleauthorJ.-W. Cheong-
dc.contributor.googleauthorJ. W. Song-
dc.contributor.googleauthorY. H. Min-
dc.identifier.doi10.1111/j.1365-3148.2008.00849.x-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA03726-
dc.contributor.localIdA01017-
dc.contributor.localIdA01407-
dc.contributor.localIdA01630-
dc.contributor.localIdA02054-
dc.contributor.localIdA00779-
dc.relation.journalcodeJ03228-
dc.identifier.eissn1365-3148-
dc.identifier.pmid18399843-
dc.identifier.urlhttp://onlinelibrary.wiley.com/doi/10.1111/j.1365-3148.2008.00849.x/abstract-
dc.subject.keywordiron overload-
dc.subject.keywordstem cell mobilization-
dc.subject.keywordtransfusion-
dc.contributor.alternativeNameChung, Joo Won-
dc.contributor.alternativeNameKim, Yu Ri-
dc.contributor.alternativeNameKim, Jin Seok-
dc.contributor.alternativeNameMin, Yoo Hong-
dc.contributor.alternativeNamePark, In Hae-
dc.contributor.alternativeNameSong, Jae Woo-
dc.contributor.affiliatedAuthorChung, Joo Won-
dc.contributor.affiliatedAuthorKim, Jin Seok-
dc.contributor.affiliatedAuthorMin, Yoo Hong-
dc.contributor.affiliatedAuthorPark, In Hae-
dc.contributor.affiliatedAuthorSong, Jae Woo-
dc.contributor.affiliatedAuthorKim, Yu Ri-
dc.rights.accessRightsnot free-
dc.citation.volume18-
dc.citation.number2-
dc.citation.startPage97-
dc.citation.endPage103-
dc.identifier.bibliographicCitationTRANSFUSION MEDICINE, Vol.18(2) : 97-103, 2008-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers

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