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Clinical implications of subclinical hypothyroidism in continuous ambulatory peritoneal dialysis patients

DC FieldValueLanguage
dc.contributor.author유태현-
dc.contributor.author한대석-
dc.contributor.author한승혁-
dc.contributor.author강신욱-
dc.contributor.author강이화-
dc.contributor.author남주영-
dc.contributor.author신석균-
dc.date.accessioned2015-05-19T16:48:49Z-
dc.date.available2015-05-19T16:48:49Z-
dc.date.issued2008-
dc.identifier.issn0250-8095-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/106992-
dc.description.abstractBACKGROUND: Despite the high prevalence of subclinical hypothyroidism in patients with chronic kidney disease, little is known about the clinical features and implications of this disorder in end-stage renal disease patients. This study aimed to investigate the clinical implications of subclinical hypothyroidism in continuous ambulatory peritoneal dialysis (CAPD) patients. METHODS: This is a cross-sectional study with 51 stable patients who were maintained on CAPD for more than 3 months. A thyroid function test with blood sampling and echocardiography were conducted. Subclinical hypothyroidism was defined as a thyrotropin (TSH) level over 5 mIU/l and normal free T(4). RESULTS: Of the 51 patients, subclinical hypothyroidism was detected in 14 (27.5%). Among those with subclinical hypothyroidism, only 4 (28.6%) patients had autoimmune thyroiditis. Patients with subclinical hypothyroidism had lower left ventricular ejection fractions (LVEF; 61.5 vs. 70.0%, p = 0.002) and lower fractional shortening at endocardial levels (endoFS; 33.9 vs. 40.0%, p = 0.009) compared to those with normal TSH levels. In addition, logTSH was inversely associated with LVEF (r = -0.361, p = 0.009) and endoFS (r = -0.320, p = 0.022). In a multivariate linear regression, adjusted for age, diabetes, previous coronary artery disease and logCRP (C-reactive protein), logTSH was an independent correlate with LVEF (beta = -0.388, p < 0.001). CONCLUSION: This study suggests that subclinical hypothyroidism is common and might be implicated in cardiac dysfunction in CAPD patients.-
dc.description.statementOfResponsibilityopen-
dc.format.extent908~913-
dc.relation.isPartOfAmerican Journal of Nephrology-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHAged, 80 and over-
dc.subject.MESHCross-Sectional Studies-
dc.subject.MESHEchocardiography-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHHypothyroidism/blood*-
dc.subject.MESHHypothyroidism/complications-
dc.subject.MESHHypothyroidism/diagnosis*-
dc.subject.MESHKidney Failure, Chronic/blood-
dc.subject.MESHKidney Failure, Chronic/complications*-
dc.subject.MESHKidney Failure, Chronic/therapy-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHPeritoneal Dialysis, Continuous Ambulatory/methods*-
dc.subject.MESHRegression Analysis-
dc.subject.MESHSystole-
dc.subject.MESHThyrotropin/metabolism-
dc.titleClinical implications of subclinical hypothyroidism in continuous ambulatory peritoneal dialysis patients-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학)-
dc.contributor.googleauthorEa Wha Kang-
dc.contributor.googleauthorJu Young Nam-
dc.contributor.googleauthorTae-Hyun Yoo-
dc.contributor.googleauthorSug Kyun Shin-
dc.contributor.googleauthorShin-Wook Kang-
dc.contributor.googleauthorDae-Suk Han-
dc.contributor.googleauthorSeung Hyeok Han-
dc.identifier.doi10.1159/000141933-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA02526-
dc.contributor.localIdA04272-
dc.contributor.localIdA04304-
dc.contributor.localIdA00053-
dc.contributor.localIdA00074-
dc.contributor.localIdA01266-
dc.contributor.localIdA02110-
dc.relation.journalcodeJ00094-
dc.identifier.pmid18580053-
dc.identifier.urlhttp://www.karger.com/Article/FullText/141933-
dc.subject.keywordSubclinical hypothyroidism-
dc.subject.keywordContinuous ambulatory peritoneal dialysis-
dc.subject.keywordLeft ventricular dysfunction-
dc.contributor.alternativeNameYoo, Tae Hyun-
dc.contributor.alternativeNameHan, Dae Suk-
dc.contributor.alternativeNameHan, Seung Hyeok-
dc.contributor.alternativeNameKang, Shin Wook-
dc.contributor.alternativeNameKang, Ea Wha-
dc.contributor.alternativeNameNam, Ju Young-
dc.contributor.alternativeNameShin, Sug Kyun-
dc.contributor.affiliatedAuthorYoo, Tae Hyun-
dc.contributor.affiliatedAuthorHan, Dae Suk-
dc.contributor.affiliatedAuthorHan, Seung Hyeok-
dc.contributor.affiliatedAuthorKang, Shin Wook-
dc.contributor.affiliatedAuthorKang, Ea Wha-
dc.contributor.affiliatedAuthorNam, Ju Young-
dc.contributor.affiliatedAuthorShin, Sug Kyun-
dc.rights.accessRightsnot free-
dc.citation.volume28-
dc.citation.number6-
dc.citation.startPage908-
dc.citation.endPage913-
dc.identifier.bibliographicCitationAmerican Journal of Nephrology, Vol.28(6) : 908-913, 2008-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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