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Proto-oncogene FBI-1 (Pokemon/ZBTB7A) represses transcription of the tumor suppressor Rb gene via binding competition with Sp1 and recruitment of co-repressors

DC FieldValueLanguage
dc.contributor.author허만욱-
dc.contributor.author유정윤-
dc.contributor.author윤호근-
dc.contributor.author전부남-
dc.contributor.author최원일-
dc.date.accessioned2015-05-19T16:47:07Z-
dc.date.available2015-05-19T16:47:07Z-
dc.date.issued2008-
dc.identifier.issn0021-9258-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/106940-
dc.description.abstractFBI-1 (also called Pokemon/ZBTB7A) is a BTB/POZ-domain Krüppel-like zinc-finger transcription factor. Recently, FBI-1 was characterized as a proto-oncogenic protein, which represses tumor suppressor ARF gene transcription. The expression of FBI-1 is increased in many cancer tissues. We found that FBI-1 potently represses transcription of the Rb gene, a tumor suppressor gene important in cell cycle arrest. FBI-1 binds to four GC-rich promoter elements (FREs) located at bp -308 to -188 of the Rb promoter region. The Rb promoter also contains two Sp1 binding sites: GC-box 1 (bp -65 to -56) and GC-box 2 (bp -18 to -9), the latter of which is also bound by FBI-1. We found that FRE3 (bp -244 to -236) is also a Sp1 binding element. FBI-1 represses transcription of the Rb gene not only by binding to the FREs, but also by competing with Sp1 at the GC-box 2 and the FRE3. By binding to the FREs and/or the GC-box, FBI-1 represses transcription of the Rb gene through its POZ-domain, which recruits a co-repressor-histone deacetylase complex and deacetylates histones H3 and H4 at the Rb gene promoter. FBI-1 inhibits C2C12 myoblast cell differentiation by repressing Rb gene expression-
dc.description.statementOfResponsibilityopen-
dc.format.extent33199~33210-
dc.relation.isPartOfJOURNAL OF BIOLOGICAL CHEMISTRY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHADP-Ribosylation Factors/antagonists & inhibitors-
dc.subject.MESHADP-Ribosylation Factors/metabolism-
dc.subject.MESHAnimals-
dc.subject.MESHCell Cycle/physiology-
dc.subject.MESHCell Differentiation/physiology-
dc.subject.MESHDNA-Binding Proteins/metabolism*-
dc.subject.MESHDrosophila melanogaster-
dc.subject.MESHHeLa Cells-
dc.subject.MESHHistone Deacetylases/metabolism-
dc.subject.MESHHistones/metabolism-
dc.subject.MESHHumans-
dc.subject.MESHMyoblasts/metabolism-
dc.subject.MESHProtein Binding/physiology-
dc.subject.MESHProtein Structure, Tertiary/physiology-
dc.subject.MESHProto-Oncogene Proteins/metabolism*-
dc.subject.MESHResponse Elements/physiology*-
dc.subject.MESHRetinoblastoma Protein/metabolism*-
dc.subject.MESHSp1 Transcription Factor/metabolism*-
dc.subject.MESHTranscription Factors/metabolism*-
dc.subject.MESHTranscription, Genetic/physiology*-
dc.titleProto-oncogene FBI-1 (Pokemon/ZBTB7A) represses transcription of the tumor suppressor Rb gene via binding competition with Sp1 and recruitment of co-repressors-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Biochemistry & Molecular Biology (생화학,분자생물학)-
dc.contributor.googleauthorBu-Nam Jeon-
dc.contributor.googleauthorJung-Yoon Yoo-
dc.contributor.googleauthorWon-Il Choi-
dc.contributor.googleauthorChoong-Eun Lee-
dc.contributor.googleauthorHo-Geun Yoon-
dc.contributor.googleauthorMan-Wook Hur-
dc.identifier.doi10.1074/jbc.M802935200-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA04350-
dc.contributor.localIdA02625-
dc.contributor.localIdA03517-
dc.contributor.localIdA04126-
dc.contributor.localIdA02502-
dc.relation.journalcodeJ01258-
dc.identifier.eissn1083-351X-
dc.identifier.pmid18801742-
dc.subject.keywordADP-Ribosylation Factors/antagonists & inhibitors-
dc.subject.keywordADP-Ribosylation Factors/metabolism-
dc.subject.keywordAnimals-
dc.subject.keywordCell Cycle/physiology-
dc.subject.keywordCell Differentiation/physiology-
dc.subject.keywordDNA-Binding Proteins/metabolism*-
dc.subject.keywordDrosophila melanogaster-
dc.subject.keywordHeLa Cells-
dc.subject.keywordHistone Deacetylases/metabolism-
dc.subject.keywordHistones/metabolism-
dc.subject.keywordHumans-
dc.subject.keywordMyoblasts/metabolism-
dc.subject.keywordProtein Binding/physiology-
dc.subject.keywordProtein Structure, Tertiary/physiology-
dc.subject.keywordProto-Oncogene Proteins/metabolism*-
dc.subject.keywordResponse Elements/physiology*-
dc.subject.keywordRetinoblastoma Protein/metabolism*-
dc.subject.keywordSp1 Transcription Factor/metabolism*-
dc.subject.keywordTranscription Factors/metabolism*-
dc.subject.keywordTranscription, Genetic/physiology*-
dc.contributor.alternativeNameHur, Man Wook-
dc.contributor.alternativeNameYoo, Jung Yoon-
dc.contributor.alternativeNameYoon, Ho Geun-
dc.contributor.alternativeNameJeon, Bu Nam-
dc.contributor.alternativeNameChoi, Won Il-
dc.contributor.affiliatedAuthorHur, Man Wook-
dc.contributor.affiliatedAuthorYoon, Ho Geun-
dc.contributor.affiliatedAuthorJeon, Bu Nam-
dc.contributor.affiliatedAuthorChoi, Won Il-
dc.contributor.affiliatedAuthorYoo, Jung Yoon-
dc.contributor.affiliatedAuthor유정윤-
dc.rights.accessRightsfree-
dc.citation.volume283-
dc.citation.number48-
dc.citation.startPage33199-
dc.citation.endPage33210-
dc.identifier.bibliographicCitationJOURNAL OF BIOLOGICAL CHEMISTRY, Vol.283(48) : 33199-33210, 2008-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Biochemistry and Molecular Biology (생화학-분자생물학교실) > 1. Journal Papers

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