Cited 62 times in
Collagen fibril formation. A new target to limit fibrosis.
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 정기양 | - |
dc.date.accessioned | 2015-05-19T16:46:48Z | - |
dc.date.available | 2015-05-19T16:46:48Z | - |
dc.date.issued | 2008 | - |
dc.identifier.issn | 0021-9258 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/106930 | - |
dc.description.abstract | We present a concept for reducing formation of fibrotic deposits by inhibiting self-assembly of collagen molecules into fibrils, a main component of fibrotic lesions. Employing monoclonal antibodies that bind to the telopeptide region of a collagen molecule, we found that blocking telopeptide-mediated collagen/collagen interactions reduces the amount of collagen fibrils accumulated in vitro and in keloid-like organotypic constructs. We conclude that inhibiting extracellular steps of the fibrotic process provides a novel approach to limit fibrosis in a number of tissues and organs. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 25879~25886 | - |
dc.relation.isPartOf | JOURNAL OF BIOLOGICAL CHEMISTRY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Antibodies, Monoclonal/chemistry | - |
dc.subject.MESH | Bone Morphogenetic Protein 1 | - |
dc.subject.MESH | Bone Morphogenetic Proteins/metabolism | - |
dc.subject.MESH | Collagen/chemistry* | - |
dc.subject.MESH | Collagen Type I/chemistry* | - |
dc.subject.MESH | Epitopes/chemistry | - |
dc.subject.MESH | Extracellular Matrix/metabolism | - |
dc.subject.MESH | Fibroblasts/metabolism | - |
dc.subject.MESH | Fibrosis | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Keloid/metabolism | - |
dc.subject.MESH | Metalloendopeptidases/metabolism | - |
dc.subject.MESH | Mice | - |
dc.subject.MESH | Mice, Nude | - |
dc.subject.MESH | Peptides/chemistry | - |
dc.subject.MESH | Skin/metabolism | - |
dc.title | Collagen fibril formation. A new target to limit fibrosis. | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Dermatology (피부과학) | - |
dc.contributor.googleauthor | Hye Jin Chung | - |
dc.contributor.googleauthor | Andrzej Steplewski | - |
dc.contributor.googleauthor | Kee Yang Chung | - |
dc.contributor.googleauthor | Jouni Uitto | - |
dc.contributor.googleauthor | Andrzej Fertala | - |
dc.identifier.doi | 10.1074/jbc.M804272200 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A03582 | - |
dc.relation.journalcode | J01258 | - |
dc.identifier.eissn | 1083-351X | - |
dc.identifier.pmid | 18650436 | - |
dc.subject.keyword | Animals | - |
dc.subject.keyword | Antibodies, Monoclonal/chemistry | - |
dc.subject.keyword | Bone Morphogenetic Protein 1 | - |
dc.subject.keyword | Bone Morphogenetic Proteins/metabolism | - |
dc.subject.keyword | Collagen/chemistry* | - |
dc.subject.keyword | Collagen Type I/chemistry* | - |
dc.subject.keyword | Epitopes/chemistry | - |
dc.subject.keyword | Extracellular Matrix/metabolism | - |
dc.subject.keyword | Fibroblasts/metabolism | - |
dc.subject.keyword | Fibrosis | - |
dc.subject.keyword | Humans | - |
dc.subject.keyword | Keloid/metabolism | - |
dc.subject.keyword | Metalloendopeptidases/metabolism | - |
dc.subject.keyword | Mice | - |
dc.subject.keyword | Mice, Nude | - |
dc.subject.keyword | Peptides/chemistry | - |
dc.subject.keyword | Skin/metabolism | - |
dc.contributor.alternativeName | Chung, Kee Yang | - |
dc.contributor.affiliatedAuthor | Chung, Kee Yang | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 283 | - |
dc.citation.number | 38 | - |
dc.citation.startPage | 25879 | - |
dc.citation.endPage | 25886 | - |
dc.identifier.bibliographicCitation | JOURNAL OF BIOLOGICAL CHEMISTRY, Vol.283(38) : 25879-25886, 2008 | - |
dc.identifier.rimsid | 56375 | - |
dc.type.rims | ART | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.