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A cyclic RGD-coated peptide nanoribbon as a selective intracellular nanocarrier

Authors
 Yong-beom Lim  ;  Oh-Joon Kwon  ;  Eunji Lee  ;  Pyung-Hwan Kim  ;  Chae-Ok Yun  ;  Myongsoo Lee 
Citation
 ORGANIC & BIOMOLECULAR CHEMISTRY, Vol.6(11) : 1944-1948, 2008 
Journal Title
 ORGANIC & BIOMOLECULAR CHEMISTRY 
ISSN
 1477-0520 
Issue Date
2008
MeSH
Amino Acid Sequence ; Circular Dichroism ; HeLa Cells ; Humans ; Jurkat Cells ; Microscopy, Electron, Transmission ; Molecular Sequence Data ; Nanostructures* ; Oligopeptides/chemistry* ; Peptides, Cyclic/chemistry*
Keywords
Amino Acid Sequence ; Circular Dichroism ; HeLa Cells ; Humans ; Jurkat Cells ; Microscopy, Electron, Transmission ; Molecular Sequence Data ; Nanostructures* ; Oligopeptides/chemistry* ; Peptides, Cyclic/chemistry*
Abstract
We have synthesized a peptide-based supramolecular building block consisting of a cyclic Arg-Gly-Asp (cRGD) peptide segment and a beta-sheet-forming peptide segment. The block peptide was shown to self-assemble into a cRGD-coated nanoribbon structure, as revealed by circular dichroism (CD), dynamic light scattering (DLS), and transmission electron microscopy (TEM) studies. We have shown that this cRGD-coated nanoribbon can encapsulate hydrophobic guest molecules and deliver them into cells. Colocalization of the nanoribbon with LysoTracker and the selective intracellular delivery results suggests that the cRGD-coated nanoribbon is likely to be internalized into the cells through integrin receptors.
Full Text
http://dx.doi.org/10.1039/b802470g
DOI
10.1039/b802470g
Appears in Collections:
5. Research Institutes (연구소) > Institute for Cancer Research (암연구소) > 1. Journal Papers
1. College of Medicine (의과대학) > Medical Research Center (임상의학연구센터) > 1. Journal Papers
Yonsei Authors
Kwon, Oh Joon(권오준)
Kim, Pyung Hwan(김평환)
Yun, Chae Ok(윤채옥)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/106909
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