Cited 28 times in
COX-2 expression and inflammatory effects by diesel exhaust particles in vitro and in vivo
DC Field | Value | Language |
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dc.contributor.author | 김형중 | - |
dc.date.accessioned | 2015-05-19T16:44:21Z | - |
dc.date.available | 2015-05-19T16:44:21Z | - |
dc.date.issued | 2008 | - |
dc.identifier.issn | 0378-4274 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/106854 | - |
dc.description.abstract | Recent studies have shown that diesel exhaust particles (DEP) have adverse effects on the respiratory tract in vitro and in vivo, related to various pro-inflammatory cytokines and inflammatory mediators. The inflammation induced by the production of cyclooxygenase (COX)-2, an important mediator of inflammation and tumor promotion, and excess eicosanoids may be central to the pathogenesis of DEP-induced airway inflammation. However, the role of COX-2 in the pathogenesis of DEP-induced lung inflammation remains unclear, especially in vivo. In this study, we demonstrated that treatment with 50 microg/ml of DEP for 24h induced the expression of the COX-2 gene at both the transcriptional and protein levels, which led to an increase in the release of prostaglandin E(2) (PGE(2)) in A549 cells. In addition, the increased levels of COX-2 and PGE(2) by DEP exposure were significantly suppressed by treatment with 50 pg/ml of dexamethasone (Dex). We also showed that exposure to 25 mg/kg of DEP induced the expression of the COX-2 protein in mouse lung tissues, and this increased COX-2 expression was attenuated by pretreatment with 5 mg/kg of Dex. These findings suggest that COX-2 may play an important role in the pathogenesis of DEP-induced pulmonary inflammation, which is effectively inhibited by glucocorticoid treatment. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 178~187 | - |
dc.relation.isPartOf | TOXICOLOGY LETTERS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Anti-Inflammatory Agents/administration & dosage | - |
dc.subject.MESH | Anti-Inflammatory Agents/pharmacology | - |
dc.subject.MESH | Anti-Inflammatory Agents/therapeutic use | - |
dc.subject.MESH | Blotting, Western | - |
dc.subject.MESH | Cell Line | - |
dc.subject.MESH | Cyclooxygenase 2/biosynthesis* | - |
dc.subject.MESH | Cyclooxygenase 2/genetics | - |
dc.subject.MESH | Dexamethasone/administration & dosage | - |
dc.subject.MESH | Dexamethasone/pharmacology | - |
dc.subject.MESH | Dexamethasone/therapeutic use | - |
dc.subject.MESH | Dinoprostone/biosynthesis | - |
dc.subject.MESH | Dose-Response Relationship, Drug | - |
dc.subject.MESH | Enzyme-Linked Immunosorbent Assay | - |
dc.subject.MESH | Epithelial Cells/drug effects* | - |
dc.subject.MESH | Epithelial Cells/enzymology | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Lung/drug effects* | - |
dc.subject.MESH | Lung/enzymology | - |
dc.subject.MESH | Lung/pathology | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Mice | - |
dc.subject.MESH | Mice, Inbred BALB C | - |
dc.subject.MESH | Particulate Matter/toxicity* | - |
dc.subject.MESH | Pneumonia/chemically induced* | - |
dc.subject.MESH | Pneumonia/enzymology | - |
dc.subject.MESH | Pneumonia/pathology | - |
dc.subject.MESH | Pneumonia/prevention & control | - |
dc.subject.MESH | Reverse Transcriptase Polymerase Chain Reaction | - |
dc.subject.MESH | Vehicle Emissions/toxicity* | - |
dc.title | COX-2 expression and inflammatory effects by diesel exhaust particles in vitro and in vivo | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | Eun-Kyung Ahn | - |
dc.contributor.googleauthor | Hyoung-Kyu Yoon | - |
dc.contributor.googleauthor | Bo Keun Jee | - |
dc.contributor.googleauthor | Hye-Jin Ko | - |
dc.contributor.googleauthor | Kweon-Haeng Lee | - |
dc.contributor.googleauthor | Hyung Jung Kim | - |
dc.contributor.googleauthor | Young Lim | - |
dc.identifier.doi | 10.1016/j.toxlet.2007.11.005 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01158 | - |
dc.relation.journalcode | J02744 | - |
dc.identifier.eissn | 1879-3169 | - |
dc.identifier.pmid | 18187276 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0378427407010119 | - |
dc.subject.keyword | Diesel exhaust particles | - |
dc.subject.keyword | Cyclooxygenase-2 | - |
dc.subject.keyword | Prostaglandin E2 | - |
dc.subject.keyword | Dexamethasone | - |
dc.contributor.alternativeName | Kim, Hyung Jung | - |
dc.contributor.affiliatedAuthor | Kim, Hyung Jung | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 176 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 178 | - |
dc.citation.endPage | 187 | - |
dc.identifier.bibliographicCitation | TOXICOLOGY LETTERS, Vol.176(3) : 178-187, 2008 | - |
dc.identifier.rimsid | 50887 | - |
dc.type.rims | ART | - |
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