Myoepithelial tumor is a mixed tumor which is commonly developed at the exocrine gland such as salivary gland and mammary gland. Myoepithelial tumor of bone tissue is a very rare type. Only 2 cases of primary myoepithelial tumor of bone tissue have been reported. We treated a primary myoepithelial tumor like mass of 5th metacarpal bone by curettage and bone graft. We report a rare case of myopeithelial tumor like mass of bone tissue with radiologic, pathologic and immunohistochemical findings and provide a review of reported cases.