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Cited 70 times in

High telomerase activity and long telomeres in advanced hepatocellular carcinomas with poor prognosis.

DC Field Value Language
dc.contributor.author김경식-
dc.contributor.author박영년-
dc.contributor.author박찬일-
dc.contributor.author오봉경-
dc.contributor.author최진섭-
dc.contributor.author유정은-
dc.date.accessioned2015-05-19T16:41:23Z-
dc.date.available2015-05-19T16:41:23Z-
dc.date.issued2008-
dc.identifier.issn0023-6837-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/106761-
dc.description.abstractTelomerase reactivation and telomere maintenance are crucial in carcinogenesis and tumor progression. In this study, the relationships between telomere parameters, chromosomal instability and clinicopathological features were evaluated in hepatocellular carcinomas (HCCs). Telomere length (TL), telomerase activity (TA) and human telomerase reverse transcriptase (hTERT) mRNA levels were measured in 49 hepatitis B virus (HBV)-related HCCs and corresponding non-tumorous tissues. The results were compared with clinicopathological data, including differentiation, multipolar mitosis (MM), anaphase bridge, immunohistochemical stain results for cytokeratin 19 (CK19) and patient outcome. TL of HCCs ranged from 4.7 to 13.1 kb, and 44.4% of HCCs showed telomere lengthening. hTERT mRNA levels and TA were closely related (P=0.008), and were significantly higher in HCCs than non-tumorous tissues. TL was significantly higher in HCCs with strong TA (P=0.048), high hTERT mRNA levels (P=0.001) and poor differentiation (P=0.041). Frequent MM was associated with poor differentiation (P=0.007) and advanced stage (P<0.001). TA was positively correlated with MM, anaphase bridges and advanced stage (P=0.019, P=0.017 and P=0.029). Thirteen (28.3%) HCCs were CK19+ and demonstrated longer telomeres than CK19- HCCs (P=0.046). Overall survival was poor in HCCs with MM >0.4 per field (P=0.016), high TA (P=0.009) and high TL ratio (HCC/non-HCC) >0.8 (P=0.044). Our results show that long telomeres, high TA and high mitotic instability are poor prognostic markers for HBV-related HCCs and their close association suggests that telomere maintenance may be important for the progression of HCCs with high chromosomal instability to more aggressive ones.-
dc.description.statementOfResponsibilityopen-
dc.formatapplication/pdf-
dc.relation.isPartOfLABORATORY INVESTIGATION-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHCarcinoma, Hepatocellular/enzymology*-
dc.subject.MESHCarcinoma, Hepatocellular/metabolism-
dc.subject.MESHCarcinoma, Hepatocellular/pathology-
dc.subject.MESHCell Differentiation/physiology-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHKeratin-19/metabolism-
dc.subject.MESHLiver Neoplasms/enzymology*-
dc.subject.MESHLiver Neoplasms/metabolism-
dc.subject.MESHLiver Neoplasms/pathology-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHMitosis/physiology*-
dc.subject.MESHPrognosis-
dc.subject.MESHRNA, Messenger/metabolism-
dc.subject.MESHTelomerase/metabolism*-
dc.subject.MESHTelomere/metabolism*-
dc.titleHigh telomerase activity and long telomeres in advanced hepatocellular carcinomas with poor prognosis.-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Pathology (병리학)-
dc.contributor.googleauthorBong-Kyeong Oh-
dc.contributor.googleauthorHaeryoung Kim-
dc.contributor.googleauthorYoung Nyun Park-
dc.contributor.googleauthorJeong Eun Yoo-
dc.contributor.googleauthorJinsub Choi-
dc.contributor.googleauthorKyung-Sik Kim-
dc.contributor.googleauthorJae Jung Lee-
dc.contributor.googleauthorChanil Park-
dc.identifier.doi10.1038/labinvest.3700710-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00299-
dc.contributor.localIdA01563-
dc.contributor.localIdA01710-
dc.contributor.localIdA02369-
dc.contributor.localIdA04199-
dc.contributor.localIdA02505-
dc.relation.journalcodeJ02150-
dc.identifier.eissn1530-0307-
dc.identifier.pmid18158557-
dc.subject.keywordhepatocellular carcinoma-
dc.subject.keywordtelomere-
dc.subject.keywordtelomerase-
dc.subject.keywordhTERT-
dc.subject.keywordmultipolar mitosis-
dc.subject.keywordprognosis-
dc.contributor.alternativeNameKim, Kyung Sik-
dc.contributor.alternativeNamePark, Young Nyun-
dc.contributor.alternativeNamePark, Chan Il-
dc.contributor.alternativeNameOh, Bong Kyeong-
dc.contributor.alternativeNameYoo, Jeong Eun-
dc.contributor.alternativeNameChoi, Jin Sub-
dc.contributor.affiliatedAuthorKim, Kyung Sik-
dc.contributor.affiliatedAuthorPark, Young Nyun-
dc.contributor.affiliatedAuthorPark, Chan Il-
dc.contributor.affiliatedAuthorOh, Bong Kyeong-
dc.contributor.affiliatedAuthorChoi, Jin Sub-
dc.contributor.affiliatedAuthorYoo, Jeong Eun-
dc.rights.accessRightsfree-
dc.citation.volume88-
dc.citation.number2-
dc.citation.startPage144-
dc.citation.endPage152-
dc.identifier.bibliographicCitationLABORATORY INVESTIGATION, Vol.88(2) : 144-152, 2008-
dc.identifier.rimsid49348-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers

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