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Staged diabetes management according to individual patient insulin resistance and beta-cell function ameliorates glycaemic control in type 2 diabetes mellitus

DC FieldValueLanguage
dc.contributor.author임승길-
dc.contributor.author차봉수-
dc.contributor.author허규연-
dc.contributor.author강은석-
dc.contributor.author안철우-
dc.contributor.author이현철-
dc.date.accessioned2015-05-19T16:40:09Z-
dc.date.available2015-05-19T16:40:09Z-
dc.date.issued2008-
dc.identifier.issn0300-0664-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/106724-
dc.description.abstractOBJECTIVE: The current consensus algorithm for management of type 2 diabetes is based on the fasting glucose concentration and glycated haemoglobin A(1c) (HbA(1c)) level. We applied a new therapeutic strategy by assessing insulin secretion and insulin resistance, in addition to glucose concentrations in individual patients. DESIGN AND PATIENTS: We enrolled 193 patients with type 2 diabetes. The patients were assigned to one of six groups according to insulin secretion measured by the serum fasting C-peptide concentration and insulin resistance measured by an insulin tolerance test (ITT). The two groups were treated differently: 108 patients were treated using a new staged diabetes management (SDM) strategy and 85 patients continued with conventional therapy. MEASUREMENTS: We compared metabolic variables in the two groups at baseline and 12 months after enrollment. RESULTS: In patients treated with the SDM strategy, fasting glucose concentration decreased from 9.8 +/- 2.1 to 8.2 +/- 1.7 mmol/l (P < 0.001). Postprandial 2-h glucose concentration decreased from 14.19 +/- 3.34 to 12.27 +/- 3.24 mmol/l (P < 0.001). HbA(1c) level decreased from 8.37 +/- 1.42% to 7.72 +/- 1.39% (P < 0.001). About 43% of the new SDM group achieved an HbA(1c) of < 7.0% compared with 25% of patients in the conventional treatment group. CONCLUSIONS: The new SDM strategy, based on individual data on insulin resistance and insulin secretion, may provide valuable clinical benefits in non-obese Korean patients with type 2 diabetes.-
dc.description.statementOfResponsibilityopen-
dc.format.extent549~555-
dc.relation.isPartOfClinical Endocrinology-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleStaged diabetes management according to individual patient insulin resistance and beta-cell function ameliorates glycaemic control in type 2 diabetes mellitus-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학)-
dc.contributor.googleauthorSung Hee Choi-
dc.contributor.googleauthorKyu Yeon Hur-
dc.contributor.googleauthorDae Jung Kim-
dc.contributor.googleauthorChul Woo Ahn-
dc.contributor.googleauthorEun Seok Kang-
dc.contributor.googleauthorBong Soo Cha-
dc.contributor.googleauthorSung Kil Lim-
dc.contributor.googleauthorKap Bum Huh-
dc.contributor.googleauthorHyun Chul Lee-
dc.identifier.doi10.1111/j.1365-2265.2008.03199.x-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA03375-
dc.contributor.localIdA03996-
dc.contributor.localIdA04343-
dc.contributor.localIdA00068-
dc.contributor.localIdA02270-
dc.contributor.localIdA03301-
dc.relation.journalcodeJ00571-
dc.identifier.urlhttp://onlinelibrary.wiley.com/doi/10.1111/j.1365-2265.2008.03199.x/abstract-
dc.contributor.alternativeNameLim, Sung Kil-
dc.contributor.alternativeNameCha, Bong Soo-
dc.contributor.alternativeNameHur, Kyu Yeon-
dc.contributor.alternativeNameKang, Eun Seok-
dc.contributor.alternativeNameAhn, Chul Woo-
dc.contributor.alternativeNameLee, Hyun Chul-
dc.contributor.affiliatedAuthorLim, Sung Kil-
dc.contributor.affiliatedAuthorCha, Bong Soo-
dc.contributor.affiliatedAuthorHur, Kyu Yeon-
dc.contributor.affiliatedAuthorKang, Eun Seok-
dc.contributor.affiliatedAuthorAhn, Chul Woo-
dc.contributor.affiliatedAuthorLee, Hyun Chul-
dc.rights.accessRightsnot free-
dc.citation.volume69-
dc.citation.number4-
dc.citation.startPage549-
dc.citation.endPage555-
dc.identifier.bibliographicCitationClinical Endocrinology, Vol.69(4) : 549-555, 2008-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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