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절제 가능한 직장암의 종양특이 직장간막절제술 후 종양학적 치료성적 및 안정성 : 1,276예 분석

DC FieldValueLanguage
dc.contributor.author김남규-
dc.contributor.author김진수-
dc.contributor.author민병소-
dc.contributor.author손승국-
dc.contributor.author이강영-
dc.contributor.author조장환-
dc.contributor.author허혁-
dc.date.accessioned2015-05-19T16:39:40Z-
dc.date.available2015-05-19T16:39:40Z-
dc.date.issued2008-
dc.identifier.issn1229-8670-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/106710-
dc.description.abstractPURPOSE: The purpose of this work was to review the oncologic outcomes and the operative safety of a tumor- specific mesorectal excision (TSME) for resectable rectal cancer. The risk factors for recurrence and survival were analyzed, and the changes in the sphincter-preserving rate with time were analyzed. METHODS: A total of 1,276 patients with rectal cancer who underwent curative surgery between 1989 and 2003 were analyzed retrospectively. The enrolled patients were registered in the Colorectal Cancer Database and were followed prospectively. RESULTS: The pathologic stages were stage I in 330 (25.9%), II in 403 (31.6%), and III in 543 (42.6%). Postoperative complications developed in 263 patients (20.6%). The rates of anal sphincter preservation were 32.6% between 1989 and 1993, 56.8% between 1994 and 1998, and 69.4 % between 1999 and 2003. With a mean follow-up of 69.4 months, the overall local recurrence (LR) rate was 5.4%. The 5-year LR rates were 3.8% in stage I, 4.7% in stage II, and 8.4% in stage III (P=0.016). A multivariate analysis revealed that the risk factors affecting LR were pN (0.005) and preoperatively increased serum CEA (P=0.008). The 5-year cancer-specific survival rates were 93.8% in stage I, 84.5% in stage II, and 64.5% in stage III (P=0.021). A multivariate analysis revealed that the factors affecting cancer-specific survival were pN (P=0.012) and circumferential resection margin (P<0.001). CONCLUSIONS: TSME for resectable rectal cancer showed acceptable operative morbidity and excellent oncologic outcomes. The trend toward sphincter preservation was obvious, and the shortening of the distal resection margin without deteriorating the oncologic outcomes was one of the major enabling factors-
dc.description.statementOfResponsibilityopen-
dc.format.extent121~133-
dc.relation.isPartOfJournal of the Korean Society of Coloproctology (대한대장항문학회지)-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.title절제 가능한 직장암의 종양특이 직장간막절제술 후 종양학적 치료성적 및 안정성 : 1,276예 분석-
dc.title.alternativeOncologic Outcomes and Safety after Tumor-specific Mesorectal Excision for Resectable Rectal Cancer: A Single Institution’s Experience with 1,276 Patients with Rectal Cancer-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Surgery (외과학)-
dc.contributor.googleauthor김남규-
dc.contributor.googleauthor민병소-
dc.contributor.googleauthor김진수-
dc.contributor.googleauthor허 혁-
dc.contributor.googleauthor이강영-
dc.contributor.googleauthor손승국-
dc.contributor.googleauthor조장환-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA01021-
dc.contributor.localIdA00353-
dc.contributor.localIdA01402-
dc.contributor.localIdA01978-
dc.contributor.localIdA02640-
dc.contributor.localIdA03894-
dc.contributor.localIdA04373-
dc.relation.journalcodeJ01864-
dc.identifier.pmidRectal cancer ; Tumor specific mesorectal excision ; Oncologic outcomes ; Safety-
dc.subject.keywordRectal cancer-
dc.subject.keywordTumor specific mesorectal excision-
dc.subject.keywordOncologic outcomes-
dc.subject.keywordSafety-
dc.contributor.alternativeNameKim, Nam Kyu-
dc.contributor.alternativeNameKim, Jin Soo-
dc.contributor.alternativeNameMin, Byung Soh-
dc.contributor.alternativeNameSohn, Seung Kook-
dc.contributor.alternativeNameLee, Kang Young-
dc.contributor.alternativeNameCho, Chang Hwan-
dc.contributor.alternativeNameHur, Hyuk-
dc.contributor.affiliatedAuthorKim, Jin Soo-
dc.contributor.affiliatedAuthorKim, Nam Kyu-
dc.contributor.affiliatedAuthorMin, Byung Soh-
dc.contributor.affiliatedAuthorSohn, Seung Kook-
dc.contributor.affiliatedAuthorLee, Kang Young-
dc.contributor.affiliatedAuthorCho, Chang Hwan-
dc.contributor.affiliatedAuthorHur, Hyuk-
dc.rights.accessRightsfree-
dc.citation.volume24-
dc.citation.number2-
dc.citation.startPage121-
dc.citation.endPage133-
dc.identifier.bibliographicCitationJournal of the Korean Society of Coloproctology (대한대장항문학회지), Vol.24(2) : 121-133, 2008-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers

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