286 498

Cited 24 times in

Diagnostic algorithm for papillary urothelial tumors in the urinary bladder.

DC Field Value Language
dc.contributor.author조강수-
dc.contributor.author조남훈-
dc.contributor.author최영득-
dc.date.accessioned2015-05-19T16:34:02Z-
dc.date.available2015-05-19T16:34:02Z-
dc.date.issued2008-
dc.identifier.issn0945-6317-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/106542-
dc.description.abstractPapillary urothelial neoplasms with deceptively bland cytology cannot be easily classified. We aimed to design a new algorithm that could differentiate between these neoplasms based on a scoring system. We proposed a new scoring system that enables to reproducibly diagnose non-invasive papillary urothelial tumors. In this system, each lesion was given individual scores from 0 to 3 for mitosis and cellular thickness, from 0 to 2 for cellular atypia, and an additional score for papillary fusion. These scores were combined to form a summed score allowing the tumors to be ranked as follows: 0-1 = UP, 2-4 = low malignant potential (LMP), 5-7 = low-grade transitional cell carcinoma (TCC), and 8-9 = high-grade TCC. In addition to the scoring system, ancillary studies of MIB and p53 indexes with CK20 expression pattern analyses were compared together with clinical parameters. The MIB index was strongly correlated with disease progression. Four of the 22 LMP patients (18.2%) had late recurrences, two of these four (9.1%) had progression to low-grade carcinoma. The MIB index for LMP patients was strongly associated with recurrence (recurrence vs. non-recurrence, 16.5 vs. 8.1, p < 0.001). The proposed scoring system could enhance the reproducibility to distinguish papillary urothelial neoplasms.-
dc.description.statementOfResponsibilityopen-
dc.format.extent353~362-
dc.relation.isPartOfVIRCHOWS ARCHIV-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAlgorithms-
dc.subject.MESHBiomarkers, Tumor/metabolism-
dc.subject.MESHCarcinoma,Papillary/classification-
dc.subject.MESHCarcinoma,Papillary/diagnosis*-
dc.subject.MESHCarcinoma,Papillary/pathology*-
dc.subject.MESHCarcinoma, Transitional Cell/classification-
dc.subject.MESHCarcinoma, Transitional Cell/diagnosis-
dc.subject.MESHCarcinoma, Transitional Cell/pathology-
dc.subject.MESHDisease Progression-
dc.subject.MESHHumans-
dc.subject.MESHIon Channels-
dc.subject.MESHKeratin-20/metabolism-
dc.subject.MESHMembrane Proteins/metabolism-
dc.subject.MESHMitotic Index-
dc.subject.MESHNeoplasm Recurrence, Local/diagnosis-
dc.subject.MESHNeoplasm Recurrence, Local/pathology-
dc.subject.MESHTumor Suppressor Protein p53/metabolism-
dc.subject.MESHUrinary BladderNeoplasms/classification-
dc.subject.MESHUrinary BladderNeoplasms/diagnosis*-
dc.subject.MESHUrinary BladderNeoplasms/pathology*-
dc.subject.MESHUrothelium/metabolism-
dc.subject.MESHUrothelium/pathology*-
dc.titleDiagnostic algorithm for papillary urothelial tumors in the urinary bladder.-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Pathology (병리학)-
dc.contributor.googleauthorJung-Weon Shim-
dc.contributor.googleauthorKang Su Cho-
dc.contributor.googleauthorYoung-Deuk Choi-
dc.contributor.googleauthorYong-Wook Park-
dc.contributor.googleauthorDong-Wha Lee-
dc.contributor.googleauthorWoon-Sup Han-
dc.contributor.googleauthorSang-In Shim-
dc.contributor.googleauthorHyun-Jung Kim-
dc.contributor.googleauthorNam Hoon Cho-
dc.identifier.doi10.1007/s00428-008-0585-x-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA03801-
dc.contributor.localIdA03812-
dc.contributor.localIdA04111-
dc.relation.journalcodeJ02784-
dc.identifier.eissn1432-2307-
dc.identifier.pmid18311491-
dc.subject.keywordPapillary urothelial neoplasm of low malignant potential-
dc.subject.keywordRecurrence-
dc.subject.keywordMIB-
dc.contributor.alternativeNameCho, Kang Su-
dc.contributor.alternativeNameCho, Nam Hoon-
dc.contributor.alternativeNameChoi, Young Deuk-
dc.contributor.affiliatedAuthorCho, Kang Su-
dc.contributor.affiliatedAuthorCho, Nam Hoon-
dc.contributor.affiliatedAuthorChoi, Young Deuk-
dc.rights.accessRightsfree-
dc.citation.volume452-
dc.citation.number4-
dc.citation.startPage353-
dc.citation.endPage362-
dc.identifier.bibliographicCitationVIRCHOWS ARCHIV, Vol.452(4) : 353-362, 2008-
dc.identifier.rimsid45999-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Urology (비뇨의학교실) > 1. Journal Papers

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.