전립선 건강검진을 받은 60세 이상의 남성에서 대사증후군과 전립선용적의 연관성

Abstract

PURPOSE: To evaluate the relationship between factors of metabolic syndrome(MS) to prostate volume and lower urinary tract symptom in men over sixties. MATERIALS AND METHODS: A total of 624 male subjects aged 60 to 90 years were enrolled. Prostate volume, urinary flow rate, voided volume, post void residual urine volume, voiding symptoms and MS-related parameters were investigated. Patients were divided into two groups; those with MS (n=223) and those without(n=401). Prostate volume, urodynamic factors and voiding symptoms were compared based upon MS categories. RESULTS: The MS and control group showed no significant differences with respect to age(74.8+/-5.6 vs. 74.0+/-5.4, respectively, p=0.083) and prostate specific antigen levels(1.8+/-1.5 vs. 1.7+/-1.5, respectively, p=0.248). However, the MS group had significantly greater waist circumference, blood pressure, fasting blood sugar level, hypertriglyceridemia and lower high density lipoprotein(HDL) cholesterol than the control group(p<0.05). Patients with MS showed significantly larger total prostate volume(p=0.008) and transitional zone volume(p=0.012). There were no differences between two groups respect to maximum flow rate, voided volume and residual volume (p>0.05). There was a significant relationship between prostate volume and obesity(p=0.016), however other MS factors such as low HDL, hypertension, non-insulin dependent diabetes mellitus and hypertriglyceridemia were not associated with prostate volume(p>0.05).CONCLUSIONS: Metabolic syndrome is associated with prostate volume related factors, but not to voiding dysfunction in Korean men over sixties. Among subcategories of MS, obesity is the most strongly related factor to prostate volume.