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Increasing prevalence of toxin A-negative, toxin B-positive isolates of Clostridium difficile in Korea: Impact on laboratory diagnosis

Authors
 Heejung Kim  ;  Thomas V. Riley  ;  Myungsook Kim  ;  Chang Ki Kim  ;  Dongeun Yong  ;  Kyungwon Lee  ;  Yunsop Chong  ;  Jong-Woo Park 
Citation
 JOURNAL OF CLINICAL MICROBIOLOGY, Vol.46(3) : 1116-1117, 2008 
Journal Title
 JOURNAL OF CLINICAL MICROBIOLOGY 
ISSN
 0095-1137 
Issue Date
2008
MeSH
Anti-Bacterial Agents/pharmacology ; Bacterial Proteins/genetics ; Bacterial Proteins/metabolism* ; Bacterial Toxins/genetics ; Bacterial Toxins/metabolism* ; Clinical Laboratory Techniques ; Clostridium difficile/isolation & purification ; Clostridium difficile/pathogenicity* ; Enterocolitis, Pseudomembranous/diagnosis* ; Enterocolitis, Pseudomembranous/epidemiology ; Enterocolitis, Pseudomembranous/microbiology ; Enterotoxins/genetics ; Enterotoxins/metabolism* ; Fluoroquinolones/pharmacology ; Humans ; Korea/epidemiology ; Microbial Sensitivity Tests ; Polymerase Chain Reaction/methods ; Prevalence
Keywords
Anti-Bacterial Agents/pharmacology ; Bacterial Proteins/genetics ; Bacterial Proteins/metabolism* ; Bacterial Toxins/genetics ; Bacterial Toxins/metabolism* ; Clinical Laboratory Techniques ; Clostridium difficile/isolation & purification ; Clostridium difficile/pathogenicity* ; Enterocolitis, Pseudomembranous/diagnosis* ; Enterocolitis, Pseudomembranous/epidemiology ; Enterocolitis, Pseudomembranous/microbiology ; Enterotoxins/genetics ; Enterotoxins/metabolism* ; Fluoroquinolones/pharmacology ; Humans ; Korea/epidemiology ; Microbial Sensitivity Tests ; Polymerase Chain Reaction/methods ; Prevalence
Abstract
Of 462 Korean Clostridium difficile isolates, 77.5% were toxin B positive but 21.4% were toxin A negative (A(-) B(+)). The binary toxin gene was detected in nine isolates. A higher fluoroquinolone resistance of A(-) B(+) strains may contribute to the increase of these strains. Toxin A detection alone may underdiagnose C. difficile-associated disease
Files in This Item:
T200800353.pdf Download
DOI
10.1128/JCM.01188-07
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Chang Ki(김창기)
Kim, Heejung(김희정) ORCID logo https://orcid.org/0000-0002-0190-703X
Yong, Dong Eun(용동은) ORCID logo https://orcid.org/0000-0002-1225-8477
Lee, Kyungwon(이경원) ORCID logo https://orcid.org/0000-0003-3788-2134
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/106509
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