Cited 10 times in
A comprehensive prognostic stratification for patients with metastatic renal clear cell carcinoma
DC Field | Value | Language |
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dc.contributor.author | 정병하 | - |
dc.contributor.author | 조강수 | - |
dc.contributor.author | 최영득 | - |
dc.contributor.author | 홍성준 | - |
dc.date.accessioned | 2015-05-19T16:32:40Z | - |
dc.date.available | 2015-05-19T16:32:40Z | - |
dc.date.issued | 2008 | - |
dc.identifier.issn | 0513-5796 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/106501 | - |
dc.description.abstract | PURPOSE: To develop a reliable prognostic model for patients with metastatic renal cell carcinoma (RCC) based on features readily available in common clinical settings. PATIENTS AND METHODS: A total of 197 patients with RCC who underwent nephrectomy and immunotherapy from 1995 to 2004 were retrospectively reviewed. Their mean age was 55.1+/-11.8 yrs (24-83yrs) and mean survival time from metastasis was 22.6+/-20.2mos (3-120mos). The impact of 24 clinicopathological features on disease specific survival was investigated. RESULTS: On univariate analysis, constitutional symptoms, sarcomatoid differentiation, tumor necrosis, multiple primary lesions, liver metastasis, Eastern Cooperative Oncology Group Performance Status (ECOG-PS), thrombocytosis, alkaline phosphatase, hematocrit, T stage, N stage, and nuclear grade had significant influence on survival (p<0.05). Multivariate analysis revealed the following features associated with survival: sarcomatoid differentiation [hazard ratio (HR)=2.99, p<0.001], liver metastasis (HR=2.09, p=0.002), ECOG-PS (HR=1.95, p= 0.005), N stage (HR=1.94, p=0.002), and number of metastatic sites (HR=1.76, p=0.003). An individual prognostic score was defined as the sum of the weight of these features. According to prognostic scores, patients could be subdivided into 3 groups: low risk (score 0), intermediate risk (score 1 or 2), and high risk (score> or =3). CONCLUSION: A comprehensive prognostic stratification model was developed to predict survival and stratify patients for prospective clinical trials | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 451~458 | - |
dc.relation.isPartOf | YONSEI MEDICAL JOURNAL | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Aged, 80 and over | - |
dc.subject.MESH | Carcinoma, Renal Cell/pathology | - |
dc.subject.MESH | Carcinoma, Renal Cell/therapy* | - |
dc.subject.MESH | Combined Modality Therapy | - |
dc.subject.MESH | Disease-Free Survival | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Immunotherapy/methods | - |
dc.subject.MESH | Kidney Neoplasms/pathology | - |
dc.subject.MESH | Kidney Neoplasms/therapy* | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Multivariate Analysis | - |
dc.subject.MESH | Neoplasm Metastasis | - |
dc.subject.MESH | Neoplasm Staging | - |
dc.subject.MESH | Nephrectomy/methods | - |
dc.subject.MESH | Prognosis | - |
dc.subject.MESH | Retrospective Studies | - |
dc.title | A comprehensive prognostic stratification for patients with metastatic renal clear cell carcinoma | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Urology (비뇨기과학) | - |
dc.contributor.googleauthor | Kang Su Cho | - |
dc.contributor.googleauthor | Young Deuk Choi | - |
dc.contributor.googleauthor | Se Joong Kim | - |
dc.contributor.googleauthor | Chun Il Kim | - |
dc.contributor.googleauthor | Byung Ha Chung | - |
dc.contributor.googleauthor | Do Hwan Seong | - |
dc.contributor.googleauthor | Dong Hyeon Lee | - |
dc.contributor.googleauthor | Jin Seon Cho | - |
dc.contributor.googleauthor | In Rae Cho | - |
dc.contributor.googleauthor | Sung Joon Hong | - |
dc.identifier.doi | 10.3349/ymj.2008.49.3.451 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A03607 | - |
dc.contributor.localId | A03801 | - |
dc.contributor.localId | A04111 | - |
dc.contributor.localId | A04402 | - |
dc.relation.journalcode | J02813 | - |
dc.identifier.eissn | 1976-2437 | - |
dc.identifier.pmid | 18581596 | - |
dc.subject.keyword | Carcinoma | - |
dc.subject.keyword | renal cell | - |
dc.subject.keyword | neoplasm metastasis | - |
dc.subject.keyword | nephrectomy | - |
dc.subject.keyword | immunotherapy | - |
dc.subject.keyword | prognosis | - |
dc.contributor.alternativeName | Chung, Byung Ha | - |
dc.contributor.alternativeName | Cho, Kang Su | - |
dc.contributor.alternativeName | Choi, Young Deuk | - |
dc.contributor.alternativeName | Hong, Sung Joon | - |
dc.contributor.affiliatedAuthor | Chung, Byung Ha | - |
dc.contributor.affiliatedAuthor | Cho, Kang Su | - |
dc.contributor.affiliatedAuthor | Choi, Young Deuk | - |
dc.contributor.affiliatedAuthor | Hong, Sung Joon | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 49 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 451 | - |
dc.citation.endPage | 458 | - |
dc.identifier.bibliographicCitation | YONSEI MEDICAL JOURNAL, Vol.49(3) : 451-458, 2008 | - |
dc.identifier.rimsid | 45966 | - |
dc.type.rims | ART | - |
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