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Alyx 성분채집기를 이용한 두 단위 백혈구제거 성분적혈구채집 경험

Other Titles
 Automated Collection of Leukoreduced Double Red Blood Cell Units using an Alyx Apheresis Device 
Authors
 이종한  ;  김문정  ;  백은정  ;  김신영  ;  김윤정  ;  홍덕진  ;  김현옥 
Citation
 Korean Journal of Blood Transfusion (대한수혈학회지), Vol.19(2) : 111-119, 2008 
Journal Title
 Korean Journal of Blood Transfusion (대한수혈학회지) 
ISSN
 1226-9336 
Issue Date
2008
Keywords
Alyx apheresis device ; Automated collection ; Leukoreduced double RBC units
Abstract
Background: Automated collection of leukoreduced double red blood cell (RBC) units has been used to improve blood collection efficiency in many countries. The aim of this study was to evaluate leukoreduced double RBC unit collection using apheresis and to determine its clinical uses. Methods: Automated leukoreduced double RBC units were collected from 17 healthy male volunteers using an Alyx apheresis device (Baxter, DeerWeld, IL). Our institutional criteria for male donors were as follows: height ≥170 cm, weight ≥70 kg, and hemoglobin ≥14.5 g/dL. Each donor's complete blood count (CBC) was determined before and after the apheresis procedure. In order to validate the final leukoreduced double RBC units, white blood cell (WBC) counts were measured manually using a Nageotte chamber. Results: Leukoreduced double RBC units were collected in an average of 27±7 min, without specific donor reactions. The average volume of one unit of leukoreduced RBCs was 281±6 mL. Each donor's hemoglobin (P<0.001) and hematocrit (P<0.001) were significantly lower after donation, though WBC and platelet counts were no different. No residual WBCs were found in the leukoreduced, filtered product upon Nageotte chamber counting. Twenty-eight units of leukoreduced RBCs from 14 donors were transfused to patients who required leukoreduced RBCs, without specific transfusion reactions. Conclusion: The Alyx apheresis device allowed for safe and effective collection of leukoreduced double RBC units from a single donor. Automatically collected leukoreduced double RBC units were transfused to patients for the first time in Korea.
Files in This Item:
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Sin Young(김신영) ORCID logo https://orcid.org/0000-0002-2609-8945
Kim, Hyun Ok(김현옥) ORCID logo https://orcid.org/0000-0002-4964-1963
Baek, Eun Jung(백은정)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/106490
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