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Family history of diabetes and risk of atherosclerotic cardiovascular disease in Korean men and women

 Ji Wan Park  ;  Ji Eun Yun  ;  Taesung Park  ;  Eorin Cho  ;  Sun Ha Jee  ;  Yangsu Jang  ;  Terri H. Beaty  ;  Jonathan M. Samet 
 ATHEROSCLEROSIS, Vol.197(1) : 224-231, 2008 
Journal Title
Issue Date
Adult ; Aged ; Aged, 80 and over ; Asian Continental Ancestry Group/statistics & numerical data* ; Atherosclerosis/ethnology* ; Cohort Studies ; Diabetes Mellitus, Type 2/ethnology* ; Family Health ; Female ; Follow-Up Studies ; Humans ; Korea/epidemiology ; Male ; Middle Aged ; Proportional Hazards Models ; Risk Factors ; Sex Distribution
Family history of diabetes ; Cardiovascular disease ; Cohort study
The importance of family history of type 2 diabetes (FHD) as a risk factor for atherosclerotic cardiovascular disease (ASCVD) remains controversial. A report of diabetes in parents and siblings was used to establish FHD in a cohort of 1,005,230 Koreans aged 30-95 years insured by the National Health Insurance Corporation who had a biennial medical evaluation during 1992-1995. ASCVD morbidity and mortality from 1993 to 2005 were examined in relation to FHD and other ASCVD risk factors. The risk of ischemic heart disease (IHD) increased significantly (19%) in men with FHD but not in women. A strong interaction was observed between FHD and personal history of diabetes for the occurrence of ASCVD; men with both diabetes and FHD were at significantly increased risk of developing IHD, cerebrovascular disease and ASCVD with hazard ratios (HR) of 2.28, 2.07, and 2.12, respectively, compared to those who had neither FHD nor type 2 diabetes. Corresponding risks were 2.64, 2.03, and 2.10 in women, respectively. This study demonstrates that risk of ASCVD is increased among those with diabetes and a family history of diabetes; suggesting that genetic factors associated with occurrence of familial diabetes may increase risk of ASCVD beyond the risk among people without FHD
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
4. Graduate School of Public Health (보건대학원) > Graduate School of Public Health (보건대학원) > 1. Journal Papers
Yonsei Authors
Yun, Ji Eun(윤지은)
Jang, Yang Soo(장양수) ORCID logo https://orcid.org/0000-0002-2169-3112
Jee, Sun Ha(지선하) ORCID logo https://orcid.org/0000-0001-9519-3068
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