2 739

Cited 22 times in

Characterization of deletions in the DYS385 flanking region and null alleles associated with AZFc microdeletions in Koreans

DC Field Value Language
dc.contributor.author이환영-
dc.contributor.author조상호-
dc.contributor.author김나영-
dc.contributor.author박명진-
dc.contributor.author신경진-
dc.contributor.author양우익-
dc.date.accessioned2015-05-19T16:30:51Z-
dc.date.available2015-05-19T16:30:51Z-
dc.date.issued2008-
dc.identifier.issn0022-1198-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/106446-
dc.description.abstractEight DYS385 allele size discrepancies and six DYS448 null types were detected among 708 Korean men when results of three in-house multiplex short tandem repeat (STR) systems were compared. The systems included both ordinary and reduced size amplicons. Sequence analysis revealed deletion mutations at two sites upstream of the DYS385 core repeats and deletion of the entire DYS448 locus. At DYS385, allele size differences were one or two repeats and were dependent on the primer set used for polymerase chain reaction (PCR) amplification. Location of the primer target sequence in a flanking region of the STR, distal or proximal to the deletion, determined allele size. Two widely used commercial kits amplify DYS385 so as to include the mutable sites. Arrangement analysis of sequence tagged sites demonstrated that the deletion patterns at DYS448 (and DYS464) were associated with arrangements of the azoospermia factor c gene (AZFc). The DYS448 deletion appears relatively frequent in Asians.-
dc.description.statementOfResponsibilityopen-
dc.format.extent331~334-
dc.relation.isPartOfJOURNAL OF FORENSIC SCIENCES-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAsian Continental Ancestry Group/genetics-
dc.subject.MESHChromosomes, Human, Y-
dc.subject.MESHGenetic Loci-
dc.subject.MESHHumans-
dc.subject.MESHKorea-
dc.subject.MESHMale-
dc.subject.MESHPolymerase Chain Reaction-
dc.subject.MESHSeminal Plasma Proteins/genetics*-
dc.subject.MESHSequence Analysis, DNA-
dc.subject.MESHSequence Deletion*-
dc.subject.MESHTandem Repeat Sequences-
dc.subject.MESHTerminal Repeat Sequences*-
dc.titleCharacterization of deletions in the DYS385 flanking region and null alleles associated with AZFc microdeletions in Koreans-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Forensic Medicine (법의학)-
dc.contributor.googleauthorMyung Jin Park-
dc.contributor.googleauthorKyoung-Jin Shin-
dc.contributor.googleauthorNa Young Kim-
dc.contributor.googleauthorWoo Ick Yang-
dc.contributor.googleauthorSang-Ho Cho-
dc.contributor.googleauthorHwan Young Lee-
dc.identifier.doi10.1111/j.1556-4029.2008.00660.x-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA03335-
dc.contributor.localIdA01456-
dc.contributor.localIdA02085-
dc.contributor.localIdA02300-
dc.contributor.localIdA03825-
dc.contributor.localIdA00349-
dc.relation.journalcodeJ01413-
dc.identifier.eissn1556-4029-
dc.identifier.pmid18366564-
dc.identifier.urlhttp://onlinelibrary.wiley.com/doi/10.1111/j.1556-4029.2008.00660.x/abstract-
dc.subject.keywordforensic science-
dc.subject.keywordY-chromosomal short tandem repeat-
dc.subject.keywordDYS385-
dc.subject.keywordDYS448-
dc.subject.keywordflanking region mutation-
dc.subject.keywordnull allele-
dc.subject.keywordAZFcdele-tion-
dc.subject.keywordKoreans-
dc.contributor.alternativeNameLee, Hwan Young-
dc.contributor.alternativeNameCho, Sang Ho-
dc.contributor.alternativeNameKim, Na Young-
dc.contributor.alternativeNamePark, Myung Jin-
dc.contributor.alternativeNameShin, Kyoung Jin-
dc.contributor.alternativeNameYang, Woo Ick-
dc.contributor.affiliatedAuthorLee, Hwan Young-
dc.contributor.affiliatedAuthorPark, Myung Jin-
dc.contributor.affiliatedAuthorShin, Kyoung Jin-
dc.contributor.affiliatedAuthorYang, Woo Ick-
dc.contributor.affiliatedAuthorCho, Sang Ho-
dc.contributor.affiliatedAuthorKim, Na Young-
dc.rights.accessRightsnot free-
dc.citation.volume53-
dc.citation.number2-
dc.citation.startPage331-
dc.citation.endPage334-
dc.identifier.bibliographicCitationJOURNAL OF FORENSIC SCIENCES, Vol.53(2) : 331-334, 2008-
dc.identifier.rimsid45926-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Forensic Medicine (법의학과) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.