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Chlamydia pneumoniae accompanied by inflammation is associated with the progression of atherosclerosis in CAPD patients: a prospective study for 3 years

DC FieldValueLanguage
dc.contributor.author이정은-
dc.contributor.author이호영-
dc.contributor.author최규헌-
dc.contributor.author한대석-
dc.contributor.author한승혁-
dc.contributor.author김동기-
dc.contributor.author문성진-
dc.contributor.author김범석-
dc.contributor.author김현진-
dc.contributor.author강신욱-
dc.date.accessioned2015-05-19T16:24:19Z-
dc.date.available2015-05-19T16:24:19Z-
dc.date.issued2008-
dc.identifier.issn0931-0509-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/106245-
dc.description.abstractBACKGROUND: The causes of accelerated atherosclerosis in end-stage renal disease (ESRD) patients are unknown, although recent studies have suggested that Chlamydia pneumoniae (Cp) infection and inflammation might be contributing factors. We aimed to evaluate the association of carotid atherosclerosis progression with Cp infection and inflammation in patients undergoing peritoneal dialysis (PD). METHODS: This is a prospective observational study. A total of 52 non-diabetic prevalent PD patients were included. The intima-media thickness of a common carotid artery (CCA-IMT) was measured at baseline and after 36 months by B-mode ultrasonography. Serum antibodies to Cp and inflammatory markers were obtained at the time of initial measurement of the CCA-IMT. RESULTS: CCA-IMT progressors (deltaCCA-IMT > or = 0.015 mm/year) had a higher prevalence of seropositivity for Cp IgA antibody, a higher level of Cp IgA antibodies indices, log IL-(interleukin-)6, and intercellular adhesion molecule-1 (ICAM-1) compared to the non-progressors (deltaCCA-IMT < 0.015 mm/year). On multivariate analysis, Cp IgA index and log IL-6 were independent risk a factors for CCA-IMT progression. Also, Cp IgA index had independent positive correlation with the magnitude of annual deltaCCA-IMT. Cp IgA antibody seropositive patients showed significantly higher mean annual deltaCCA-IMT than seronegative patients. Moreover, patients with both positive Cp IgA antibodies and elevated IL-6 above the median level showed higher deltaCCA-IMT than those with either factor alone. CONCLUSIONS: Our data showed that Cp and inflammation were significant risk factors of CCA-IMT change in PD patients. This study strengthens evidence that Cp is involved in the pathogenesis of atherosclerosis and also suggests that the effect of Cp infection under high inflammatory status might be a risk factor for progression of atherosclerosis.-
dc.description.statementOfResponsibilityopen-
dc.format.extent1011~1018-
dc.relation.isPartOfNephrology Dialysis Transplantation-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleChlamydia pneumoniae accompanied by inflammation is associated with the progression of atherosclerosis in CAPD patients: a prospective study for 3 years-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학)-
dc.contributor.googleauthorDong Ki Kim-
dc.contributor.googleauthorHyun Jin Kim-
dc.contributor.googleauthorSeung Hyeok Han-
dc.contributor.googleauthorJung Eun Lee-
dc.contributor.googleauthorSung Jin Moon-
dc.contributor.googleauthorBeom Seok Kim-
dc.contributor.googleauthorShin-Wook Kang-
dc.contributor.googleauthorKyu Hun Choi-
dc.contributor.googleauthorHo Yung Lee-
dc.contributor.googleauthorDae-Suk Han-
dc.identifier.doi10.1093/ndt/gfm696-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA03326-
dc.contributor.localIdA04043-
dc.contributor.localIdA04272-
dc.contributor.localIdA04304-
dc.contributor.localIdA01364-
dc.contributor.localIdA00488-
dc.contributor.localIdA01141-
dc.contributor.localIdA00053-
dc.contributor.localIdA03119-
dc.contributor.localIdA00400-
dc.relation.journalcodeJ02316-
dc.contributor.alternativeNameLee, Jung Eun-
dc.contributor.alternativeNameLee, Ho Yung-
dc.contributor.alternativeNameChoi, Kyu Hun-
dc.contributor.alternativeNameHan, Dae Suk-
dc.contributor.alternativeNameHan, Seung Hyeok-
dc.contributor.alternativeNameKim, Dong Ki-
dc.contributor.alternativeNameMoon, Sung Jin-
dc.contributor.alternativeNameKim, Beom Seok-
dc.contributor.alternativeNameKim, Hyun Jin-
dc.contributor.alternativeNameKang, Shin Wook-
dc.contributor.affiliatedAuthorLee, Ho Yung-
dc.contributor.affiliatedAuthorChoi, Kyu Hun-
dc.contributor.affiliatedAuthorHan, Dae Suk-
dc.contributor.affiliatedAuthorHan, Seung Hyeok-
dc.contributor.affiliatedAuthorMoon, Sung Jin-
dc.contributor.affiliatedAuthorKim, Beom Seok-
dc.contributor.affiliatedAuthorKim, Hyun Jin-
dc.contributor.affiliatedAuthorKang, Shin Wook-
dc.contributor.affiliatedAuthorLee, Jung Eun-
dc.contributor.affiliatedAuthorKim, Dong Ki-
dc.rights.accessRightsfree-
dc.citation.volume23-
dc.citation.number3-
dc.citation.startPage1011-
dc.citation.endPage1018-
dc.identifier.bibliographicCitationNephrology Dialysis Transplantation, Vol.23(3) : 1011-1018, 2008-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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