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Lithospermic acid B ameliorates the development of diabetic nephropathy in OLETF rats

Authors
 un Seok Kang  ;  Geun Taek Lee  ;  Beom Seok Kim  ;  Chul Hoon Kim  ;  Gi Ho Seo  ;  Seung Jin Han  ;  Kyu Yeon Hur  ;  Chul Woo Ahn  ;  Hunjoo Ha  ;  Mankil Jung  ;  Young Soo Ahn  ;  Bong Soo Cha  ;  Hyun Chul Lee 
Citation
 EUROPEAN JOURNAL OF PHARMACOLOGY, Vol.579(1) : 418-425, 2008 
Journal Title
 EUROPEAN JOURNAL OF PHARMACOLOGY 
ISSN
 0014-2999 
Issue Date
2008
MeSH
Administration, Oral ; Aldehyde Reductase/antagonists & inhibitors* ; Animals ; Benzofurans/isolation & purification ; Benzofurans/pharmacology* ; Blood Glucose/drug effects ; Blood Pressure/drug effects ; Chemokine CCL2/drug effects ; Chemokine CCL2/genetics ; Depsides/isolation & purification ; Depsides/pharmacology* ; Diabetes Mellitus, Type 2/complications* ; Diabetic Nephropathies/prevention & control* ; Gene Expression Regulation/drug effects ; Male ; Oxidative Stress/drug effects ; Rats ; Rats, Inbred OLETF ; Rats, Long-Evans ; Salvia miltiorrhiza/chemistry
Keywords
Lithospermate B ; OLETF rats ; Diabetic nephropathy ; Oxidative stress ; MCP-1 ; Type 2 diabetes
Abstract
Lithospermic acid B (LAB), an active component isolated from Salvia miltiorrhizae, has been reported to have renoprotective effects in type 1 diabetic animal models. In the present study we investigated the effects of LAB on the prevention of diabetic nephropathy in type 2 diabetic Otsuka Long-Evans-Tokushima Fatty (OLETF) rats. LAB (20 mg/kg) was given orally once daily to 10-week-old male OLETF rats for 28 weeks. Treatment of OLETF rats with LAB had little effects on body weight and blood glucose levels. Treatment with LAB resulted in significant reduction in blood pressure. LAB markedly attenuated albuminuria and significantly lowered levels of lipid peroxidation, monocyte chemoattractant protein-1 (MCP-1), and transforming growth factor-beta (TGF-beta1) expression in renal tissues of OLETF rats. In addition, LAB inhibited the progression of glomerular hypertrophy, mesangial expansion, and expansion of the extracellular matrix in the renal cortex. Collectively, these results suggest that LAB has beneficial effects on the diabetic nephropathy in OLETF rats by decreasing blood pressure, oxidative stress, and MCP-1 expression. Our results suggest that LAB might be a new therapeutic agent for the prevention of nephropathy in type 2 diabetes
Full Text
http://www.sciencedirect.com/science/article/pii/S0014299907012241
DOI
10.1016/j.ejphar.2007.10.070
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pharmacology (약리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Medical Research Center (임상의학연구센터) > 1. Journal Papers
Yonsei Authors
Kang, Eun Seok(강은석) ORCID logo https://orcid.org/0000-0002-0364-4675
Kim, Beom Seok(김범석) ORCID logo https://orcid.org/0000-0002-5732-2583
Kim, Chul Hoon(김철훈) ORCID logo https://orcid.org/0000-0002-7360-429X
Ahn, Young Soo(안영수)
Ahn, Chul Woo(안철우) ORCID logo https://orcid.org/0000-0003-3733-7486
Lee, Geun Taek(이근택)
Lee, Hyun Chul(이현철)
Cha, Bong Soo(차봉수) ORCID logo https://orcid.org/0000-0003-0542-2854
Ha, Hun Joo(하헌주)
Han, Seung Jin(한승진)
Hur, Kyu Yeon(허규연)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/106212
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