Metabotropic glutamate receptors: phosphorylation and receptor signaling

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MeSH: Animals ; Models, Biological ; Phosphorylation ; Receptors, Metabotropic Glutamate/metabolism ; Receptors, Metabotropic Glutamate/physiology* ; Signal Transduction/physiology* ; Synapses/physiology*

Keywords: mGluR ; phosphorylation ; protein kinase ; protein phosphatase ; desensitization ; endocytosis ; synaptic plasticity

Abstract: Metabotropic glutamate receptors (mGluRs) play important roles in neurotransmission, neuronal development, synaptic plasticity, and neurological disorders. Recent studies have revealed a sophisticated interplay between mGluRs and protein kinases: activation of mGluRs regulates the activity of a number of kinases, and direct phosphorylation of mGluRs affects receptor signaling, trafficking, and desensitization. Here we review the emerging literature on mGluR phosphorylation, signaling, and synaptic function

Appears in Collections:: 1. College of Medicine (의과대학) > Dept. of Pharmacology (약리학교실) > 1. Journal Papers

Yonsei Authors: Kim, Chul Hoon(김철훈) https://orcid.org/0000-0002-7360-429X
Lee, Jae Youn(이재연)

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