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Increased expression of CC chemokine ligand 18 in extrinsic atopic dermatitis patients.

DC FieldValueLanguage
dc.contributor.author이광훈-
dc.contributor.author이민걸-
dc.contributor.author이주희-
dc.date.accessioned2015-05-19T16:23:00Z-
dc.date.available2015-05-19T16:23:00Z-
dc.date.issued2008-
dc.identifier.issn0906-6705-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/106205-
dc.description.abstractBACKGROUND: Although most patients with atopic dermatitis (AD) show high total and allergen-specific serum immunoglobulin E (IgE) levels, a small subgroup of AD patients have normal total IgE levels and negative serum allergen-specific IgE. This subgroup has been termed 'intrinsic' AD (IAD) as a counterpart to 'extrinsic' AD (EAD). However, the difference of chemokines between IAD and EAD has not yet been evaluated. OBJECTIVE: We investigated the expression of CC chemokine ligand (CCL) 17, CCL22, and CCL18 in patients with IAD and EAD, which are known to be highly expressed in AD patients. METHODS: We assessed the protein levels of these chemokines in peripheral blood mononuclear cells (PBMCs), sera and lesional skins. We also evaluated CCL18 mRNA levels in monocytes, Langerhans cell (LC)-like dendritic cells (DCs) and inflammatory dendritic epidermal cell (IDEC)-like DCs from both types of AD patients. RESULTS: There were no significant differences in CCL17 and CCL22 expression in PBMCs, sera and lesional skins of patients with IAD and EAD. CCL18 expression did not differ in PBMCs, sera and LC-like DCs from the two subgroups, but strong CCL18 expression was observed in lesional skins and IDEC-like DCs in patients with EAD. Lastly, serum CCL18 levels significantly decreased after immunotherapy. CONCLUSION: This study suggests that the chemokine micromilieu, especially the level of CCL18, is different between EAD and IAD patients. High FcepsilonRI surface-expressing DCs, such as IDEC, were the major source of CCL18, and produced a prominent CCL18 microenvironment in EAD patients compared with IAD patients.-
dc.description.statementOfResponsibilityopen-
dc.format.extent24~29-
dc.relation.isPartOfEXPERIMENTAL DERMATOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdolescent-
dc.subject.MESHAdult-
dc.subject.MESHBiopsy-
dc.subject.MESHCase-Control Studies-
dc.subject.MESHCells, Cultured-
dc.subject.MESHChemokine CCL17/metabolism-
dc.subject.MESHChemokine CCL22/metabolism-
dc.subject.MESHChemokines, CC/metabolism*-
dc.subject.MESHChild-
dc.subject.MESHDermatitis, Atopic/classification*-
dc.subject.MESHDermatitis, Atopic/metabolism*-
dc.subject.MESHDermatitis, Atopic/pathology-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHImmunoglobulin E/blood-
dc.subject.MESHLangerhans Cells/metabolism-
dc.subject.MESHLangerhans Cells/pathology-
dc.subject.MESHMale-
dc.subject.MESHMonocytes/metabolism-
dc.subject.MESHMonocytes/pathology-
dc.subject.MESHSkin/metabolism*-
dc.subject.MESHSkin/pathology-
dc.titleIncreased expression of CC chemokine ligand 18 in extrinsic atopic dermatitis patients.-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Dermatology (피부과학)-
dc.contributor.googleauthorChang Ook Park-
dc.contributor.googleauthorHee Jung Lee-
dc.contributor.googleauthorJu Hee Lee-
dc.contributor.googleauthorWen Hao Wu-
dc.contributor.googleauthorNam Soo Chang-
dc.contributor.googleauthorLiu Hua-
dc.contributor.googleauthorMin-Geol Lee-
dc.contributor.googleauthorKwang Hoon Lee-
dc.identifier.doi10.1111/j.1600-0625.2007.00634.x-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA02779-
dc.contributor.localIdA02674-
dc.contributor.localIdA03171-
dc.relation.journalcodeJ00866-
dc.identifier.eissn1600-0625-
dc.identifier.pmid17979978-
dc.identifier.urlhttp://onlinelibrary.wiley.com/doi/10.1111/j.1600-0625.2007.00634.x/abstract-
dc.subject.keywordatopic dermatitis-
dc.subject.keywordCCL18-
dc.subject.keywordinflammatory dendriticepidermal cell-
dc.subject.keywordLangerhans cell-
dc.contributor.alternativeNameLee, Kwang Hoon-
dc.contributor.alternativeNameLee, Min Geol-
dc.contributor.alternativeNameLee, Ju Hee-
dc.contributor.affiliatedAuthorLee, Min Geol-
dc.contributor.affiliatedAuthorLee, Kwang Hoon-
dc.contributor.affiliatedAuthorLee, Ju Hee-
dc.rights.accessRightsnot free-
dc.citation.volume17-
dc.citation.number1-
dc.citation.startPage24-
dc.citation.endPage29-
dc.identifier.bibliographicCitationEXPERIMENTAL DERMATOLOGY, Vol.17(1) : 24-29, 2008-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Dermatology (피부과학교실) > 1. Journal Papers

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