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Exaggerated blood pressure response to exercise is associated with augmented rise of angiotensin II during exercise

Authors
 Chi Young Shim  ;  Jong-Won Ha  ;  Sungha Park  ;  Eui-Young Choi  ;  Donghoon Choi  ;  Se-Joong Rim  ;  Namsik Chung 
Citation
 JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, Vol.52(4) : 287-292, 2008 
Journal Title
 JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY 
ISSN
 0735-1097 
Issue Date
2008
Keywords
angiotensin II ; catecholamine ; blood pressure ; exercise.
Abstract
OBJECTIVES: The aim of this study was to investigate the association between an exaggerated blood pressure (BP) response to exercise and augmented angiotensin (Ang) II rise during exercise. BACKGROUND: Although a central pressor effect of Ang II has been implicated in the pathogenesis of hypertension, the relationship between Ang II and exaggerated BP response to exercise is unclear. METHODS: Thirty-six subjects with an exaggerated BP response to exercise (18 men, age 50 +/- 16 years, Group II) were compared with 36 age- and gender-matched control subjects (18 men, age 50 +/- 16 years, Group I) with normal BP reactivity. The subjects who had resting BP >or=140/90 mm Hg or were treated with any antihypertensive drugs were excluded. The blood was sampled at rest and immediately after peak exercise for measurement of renin, Ang II, aldosterone, and catecholamine. RESULTS: At rest, there were no significant differences in BP, renin, aldosterone, and catecholamine levels between the 2 groups. The renin, aldosterone, and catecholamine were increased during exercise, but there were no significant differences between the groups. However, log Ang II at rest (0.78 +/- 0.32 vs. 0.98 +/- 0.38, p = 0.004) and peak exercise (0.84 +/- 0.35 vs. 1.17 +/- 0.51, p < 0.001) and the magnitude of the increment of log Ang II with exercise (0.06 +/- 0.12 vs. 0.19 +/- 0.20, p = 0.003) were significantly higher in the exaggerated BP response group.CONCLUSIONS: An exaggerated BP response to exercise was associated with augmented rise of Ang II during exercise.
Files in This Item:
T200800073.pdf Download
DOI
10.1016/j.jacc.2008.03.052
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Park, Sung Ha(박성하) ORCID logo https://orcid.org/0000-0001-5362-478X
Shim, Chi Young(심지영) ORCID logo https://orcid.org/0000-0002-6136-0136
Rim, Se Joong(임세중) ORCID logo https://orcid.org/0000-0002-7631-5581
Chung, Nam Sik(정남식)
Choi, Dong Hoon(최동훈) ORCID logo https://orcid.org/0000-0002-2009-9760
Choi, Eui Young(최의영) ORCID logo https://orcid.org/0000-0003-3732-0190
Ha, Jong Won(하종원) ORCID logo https://orcid.org/0000-0002-8260-2958
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/106194
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