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염증성 장질환 환자에서 Azathioprine/6-Mercaptopurine 치료의 부작용: 빈도와 경과
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김원호 | - |
dc.contributor.author | 김재학 | - |
dc.contributor.author | 천재희 | - |
dc.date.accessioned | 2015-05-19T16:22:37Z | - |
dc.date.available | 2015-05-19T16:22:37Z | - |
dc.date.issued | 2008 | - |
dc.identifier.issn | 1598-9992 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/106193 | - |
dc.description.abstract | BACKGROUND/AIMS: This study was to evaluate the frequency and the course of the adverse effects of AZA/6-MP in Korean patients with inflammatory bowel disease (IBD). METHODS: Medical records of the patients with IBD treated with AZA/6-MP at Severance hospital from June 1996 to September 2006 were retrospectively analyzed. RESULTS: A total of 133 patients were studied. Male to female ratio was 1.3:1. The mean age was 31.7+/-10.9 year. Adverse effects included leukopenia occurred in 75 cases (56.4%), nausea/vomiting in 32 cases (24.1%), arthralgia in 6 cases (4.5%), hepatitis in 6 cases (4.5%), skin rash in 4 cases (3.0%), herpes zoster in 3 cases (2.3%), and headache in 1 case (0.8%). Most of leucopenia (58.7%) developed within 3 months after maximal tolerated dose of AZA/6-MP and nausea/vomiting frequently occurred within 3 months after start of AZA/6-MP treatment. Thirty-eight patients (28.6%) required the discontinuation of medication due to adverse effects. CONCLUSIONS: Leukopenia was the most common adverse effect of AZA/6-MP treatment. Leukopenia and nausea/vomiting developed frequently in the early period of treatment of AZA/6-MP in patients with IBD. AZA/6-MP should be used cautiously to scrutinize bone marrow suppression | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 291~297 | - |
dc.language | Korean Journal of Gastroenterology | - |
dc.publisher | Korean Journal of Gastroenterology | - |
dc.relation.isPartOf | Korean Journal of Gastroenterology | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | 염증성 장질환 환자에서 Azathioprine/6-Mercaptopurine 치료의 부작용: 빈도와 경과 | - |
dc.title.alternative | The Frequency and the Course of the Adverse Effects of Azathioprine/6-Mercaptopurine Treatment in Patients with Inflammatory Bowel Disease. | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | 김재학 | - |
dc.contributor.googleauthor | 천재희 | - |
dc.contributor.googleauthor | 김원호 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00774 | - |
dc.contributor.localId | A00871 | - |
dc.contributor.localId | A04030 | - |
dc.relation.journalcode | J02015 | - |
dc.identifier.eissn | 2233-6869 | - |
dc.identifier.pmid | Azathioprine ; 6-Mercaptopurine ; Adverse effects ; Leukopenia ; Inflammatory bowel disease | - |
dc.subject.keyword | Azathioprine | - |
dc.subject.keyword | 6-Mercaptopurine | - |
dc.subject.keyword | Adverse effects | - |
dc.subject.keyword | Leukopenia | - |
dc.subject.keyword | Inflammatory bowel disease | - |
dc.contributor.alternativeName | Kim, Won Ho | - |
dc.contributor.alternativeName | Kim, Jae Hak | - |
dc.contributor.alternativeName | Cheon, Jae Hee | - |
dc.contributor.affiliatedAuthor | Kim, Won Ho | - |
dc.contributor.affiliatedAuthor | Kim, Jae Hak | - |
dc.contributor.affiliatedAuthor | Cheon, Jae Hee | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 51 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 291 | - |
dc.citation.endPage | 297 | - |
dc.identifier.bibliographicCitation | Korean Journal of Gastroenterology, Vol.51(5) : 291-297, 2008 | - |
dc.identifier.rimsid | 54787 | - |
dc.type.rims | ART | - |
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