Cited 7 times in
The optimal bolus dose of alfentanil for tracheal intubation during sevoflurane induction without neuromuscular blockade in day-case anaesthesia
DC Field | Value | Language |
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dc.contributor.author | 곽영란 | - |
dc.date.accessioned | 2015-05-19T16:21:39Z | - |
dc.date.available | 2015-05-19T16:21:39Z | - |
dc.date.issued | 2008 | - |
dc.identifier.issn | 0001-5172 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/106164 | - |
dc.description.abstract | BACKGROUND: The purpose of this study was to determine the optimal bolus dose of alfentanil required to provide successful intubating conditions following inhalation induction of anaesthesia using 5% sevoflurane and 60% nitrous oxide without neuromuscular blockade in adult day-case anaesthesia. METHODS: Twenty-four adults, aged 18-60 years, undergoing general anaesthesia for short ambulatory surgery were enroled into the study. After vital capacity induction, with sevoflurane 5% and 60% nitrous oxide in oxygen, pre-determined dose of alfentanil was injected over 30 s. The dose of alfentanil was determined by modified Dixon's up-and-down method (2 microg/kg as a step size). Ninety seconds after the end of bolus administration of alfentanil, the trachea was intubated. Systolic blood pressure, heart rate and SpO2 were recorded at anaesthetic induction, before, 1 min and 3 min after intubation. RESULTS: The bolus dose of alfentanil for successful tracheal intubation was 10.7+/-2.1 microg/kg in 50% of patients during inhalation induction. From probit analysis, 50% effective dose (ED(50)) and ED(95) values (95% confidence limits) of alfentanil were 10.7 microg/kg (8.0-12.9 microg/kg) and 14.9 microg/kg (12.9-31.1 microg/kg), respectively. CONCLUSIONS: Using the modified Dixon's up-and-down method, the bolus dose of alfentanil for successful tracheal intubation was 10.7+/-2.1 microg/kg in 50% of adult patients during inhalation induction using 5% sevoflurane and 60% nitrous oxide in oxygen without neuromuscular blocking agent in day-case anaesthesia. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 106~110 | - |
dc.relation.isPartOf | ACTA ANAESTHESIOLOGICA SCANDINAVICA | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adolescent | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Alfentanil/administration & dosage* | - |
dc.subject.MESH | Alfentanil/pharmacology | - |
dc.subject.MESH | Ambulatory Surgical Procedures* | - |
dc.subject.MESH | Anesthesia, Inhalation* | - |
dc.subject.MESH | Anesthetics, Inhalation/administration & dosage | - |
dc.subject.MESH | Anesthetics, Inhalation/adverse effects* | - |
dc.subject.MESH | Anesthetics, Inhalation/pharmacology | - |
dc.subject.MESH | Dose-Response Relationship, Drug | - |
dc.subject.MESH | Drug Interactions | - |
dc.subject.MESH | Electroencephalography/drug effects | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Hemodynamics/drug effects | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Injections, Intravenous | - |
dc.subject.MESH | Intubation, Intratracheal* | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Methyl Ethers/administration & dosage | - |
dc.subject.MESH | Methyl Ethers/adverse effects* | - |
dc.subject.MESH | Methyl Ethers/pharmacology | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Narcotics/administration & dosage* | - |
dc.subject.MESH | Narcotics/pharmacology | - |
dc.subject.MESH | Neuromuscular Blockade* | - |
dc.subject.MESH | Nitrous Oxide/administration & dosage | - |
dc.title | The optimal bolus dose of alfentanil for tracheal intubation during sevoflurane induction without neuromuscular blockade in day-case anaesthesia | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Anesthesiology (마취통증의학) | - |
dc.contributor.googleauthor | Kim JY | - |
dc.contributor.googleauthor | Kwak YL | - |
dc.contributor.googleauthor | Lee KC | - |
dc.contributor.googleauthor | Chang YJ | - |
dc.contributor.googleauthor | Kwak HJ | - |
dc.identifier.doi | 10.1111/j.1399-6576.2007.01477.x | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00172 | - |
dc.relation.journalcode | J00006 | - |
dc.identifier.eissn | 1399-6576 | - |
dc.identifier.pmid | 17976223 | - |
dc.identifier.url | http://onlinelibrary.wiley.com/doi/10.1111/j.1399-6576.2007.01477.x/abstract | - |
dc.subject.keyword | alfentanil | - |
dc.subject.keyword | sevoflurane | - |
dc.subject.keyword | ambulatory surgicalprocedure | - |
dc.contributor.alternativeName | Kwak, Young Lan | - |
dc.contributor.affiliatedAuthor | Kwak, Young Lan | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 52 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 106 | - |
dc.citation.endPage | 110 | - |
dc.identifier.bibliographicCitation | ACTA ANAESTHESIOLOGICA SCANDINAVICA, Vol.52(1) : 106-110, 2008 | - |
dc.identifier.rimsid | 54764 | - |
dc.type.rims | ART | - |
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