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Effect of ramosetron on patient-controlled analgesia related nausea and vomiting after spine surgery in highly susceptible patients: comparison with ondansetron.

DC Field Value Language
dc.contributor.author곽영란-
dc.contributor.author심재광-
dc.contributor.author윤도흠-
dc.contributor.author이지연-
dc.contributor.author전덕희-
dc.contributor.author최용선-
dc.date.accessioned2015-05-19T16:20:54Z-
dc.date.available2015-05-19T16:20:54Z-
dc.date.issued2008-
dc.identifier.issn0362-2436-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/106141-
dc.description.abstractSTUDY DESIGN: A prospective, randomized, double-blind clinical trial. OBJECTIVE: To compare the effect of ramosetron with that of ondansetron on opioid-based IV patient-controlled analgesia (PCA) related postoperative nausea and vomiting (PONV) in highly susceptible patients after lumbar spine surgery. SUMMARY OF BACKGROUND DATA: Optimal postoperative pain management is important to facilitate early mobilization after lumbar spine surgery. Opioid analgesia is associated with a high incidence of PONV. Among the currently available 5-hydroxytryptamine receptor 3 antagonists (5-HT3), ondansetron is being most widely used with unsatisfactory results regarding opioid-based IV PCA related PONV. Ramosetron is a newly developed 5-HT3 antagonist with higher receptor affinity and longer duration of action having theoretical advantage over ondansetron in this setting. However, data to support this view are lacking. METHODS: All 94 female nonsmoker patients (aged 18-65 years) were randomly allocated into either ondansetron group (group O, n = 47) or ramosetron group (group R, n = 47). Fentanyl-based IV PCA was administered for 48 hours after surgery. Overall incidence and severity of nausea and incidence of vomiting were assessed for 48 hours after surgery. Secondary measures included: pain intensity and total amount of administered rescue analgesic. RESULTS: Patients' characteristics were similar between the groups. Overall incidence of nausea was similar between the groups; however, moderate to severe degree of nausea was significantly more in the group O (34%) than in the group R (13%) 6 to 24 hours after surgery. Overall incidence of vomiting and use of rescue antiemetic 6 to 24 hours after surgery was significantly lower in the group R (30% vs. 11% and 28% vs. 11%, respectively). Pain scores at 24 to 48 hours after surgery were significantly lower in the group R (31 +/- 25 vs. 13 +/- 15). CONCLUSION: Ramosetron was superior to ondansetron in terms of preventing vomiting and reducing the severity of nausea related to fentanyl-based IV PCA, with less adverse events, in patients with high susceptibility, undergoing lumbar spine surgery.-
dc.description.statementOfResponsibilityopen-
dc.format.extentE602~E606-
dc.relation.isPartOfSPINE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdolescent-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHAnalgesia, Patient-Controlled/adverse effects*-
dc.subject.MESHAnalgesia, Patient-Controlled/methods-
dc.subject.MESHBenzimidazoles/therapeutic use*-
dc.subject.MESHDouble-Blind Method-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHMiddle Aged-
dc.subject.MESHOndansetron/therapeutic use*-
dc.subject.MESHPostoperative Nausea and Vomiting/etiology-
dc.subject.MESHPostoperative Nausea and Vomiting/prevention & control*-
dc.subject.MESHProspective Studies-
dc.subject.MESHSpinal Diseases/drug therapy-
dc.subject.MESHSpinal Diseases/surgery-
dc.titleEffect of ramosetron on patient-controlled analgesia related nausea and vomiting after spine surgery in highly susceptible patients: comparison with ondansetron.-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Neurosurgery (신경외과학)-
dc.contributor.googleauthorYong Seon Choi-
dc.contributor.googleauthorJae Kwang Shim-
dc.contributor.googleauthorDo Heum Yoon-
dc.contributor.googleauthorDuck Heeh Jeon-
dc.contributor.googleauthorJi Yeon Lee-
dc.contributor.googleauthorYoung Lan Kwak-
dc.identifier.doi10.1097/BRS.0b013e31817c6bde-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00172-
dc.contributor.localIdA02205-
dc.contributor.localIdA02546-
dc.contributor.localIdA03508-
dc.contributor.localIdA04119-
dc.contributor.localIdA03195-
dc.relation.journalcodeJ02674-
dc.identifier.eissn1528-1159-
dc.identifier.pmid18670328-
dc.identifier.urlhttp://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&AN=00007632-200808010-00021&LSLINK=80&D=ovft-
dc.subject.keywordAdolescent-
dc.subject.keywordAdult-
dc.subject.keywordAged-
dc.subject.keywordAnalgesia, Patient-Controlled/adverse effects*-
dc.subject.keywordAnalgesia, Patient-Controlled/methods-
dc.subject.keywordBenzimidazoles/therapeutic use*-
dc.subject.keywordDouble-Blind Method-
dc.subject.keywordFemale-
dc.subject.keywordHumans-
dc.subject.keywordMiddle Aged-
dc.subject.keywordOndansetron/therapeutic use*-
dc.subject.keywordPostoperative Nausea and Vomiting/etiology-
dc.subject.keywordPostoperative Nausea and Vomiting/prevention & control*-
dc.subject.keywordProspective Studies-
dc.subject.keywordSpinal Diseases/drug therapy-
dc.subject.keywordSpinal Diseases/surgery-
dc.contributor.alternativeNameKwak, Young Lan-
dc.contributor.alternativeNameShim, Jae Kwang-
dc.contributor.alternativeNameYoon, Do Heum-
dc.contributor.alternativeNameLee, Ji Yeon-
dc.contributor.alternativeNameChun, Duk Hee-
dc.contributor.alternativeNameChoi, Yong Seon-
dc.contributor.affiliatedAuthorKwak, Young Lan-
dc.contributor.affiliatedAuthorShim, Jae Kwang-
dc.contributor.affiliatedAuthorYoon, Do Heum-
dc.contributor.affiliatedAuthorChun, Duk Hee-
dc.contributor.affiliatedAuthorChoi, Yong Seon-
dc.contributor.affiliatedAuthorLee, Ji Yeon-
dc.rights.accessRightsnot free-
dc.citation.volume33-
dc.citation.number17-
dc.citation.startPage602-
dc.citation.endPage606-
dc.identifier.bibliographicCitationSPINE, Vol.33(17) : 602-606, 2008-
dc.identifier.rimsid54747-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Anesthesiology and Pain Medicine (마취통증의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학교실) > 1. Journal Papers

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