Cited 51 times in
Effect of ramosetron on patient-controlled analgesia related nausea and vomiting after spine surgery in highly susceptible patients: comparison with ondansetron.
DC Field | Value | Language |
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dc.contributor.author | 곽영란 | - |
dc.contributor.author | 심재광 | - |
dc.contributor.author | 윤도흠 | - |
dc.contributor.author | 이지연 | - |
dc.contributor.author | 전덕희 | - |
dc.contributor.author | 최용선 | - |
dc.date.accessioned | 2015-05-19T16:20:54Z | - |
dc.date.available | 2015-05-19T16:20:54Z | - |
dc.date.issued | 2008 | - |
dc.identifier.issn | 0362-2436 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/106141 | - |
dc.description.abstract | STUDY DESIGN: A prospective, randomized, double-blind clinical trial. OBJECTIVE: To compare the effect of ramosetron with that of ondansetron on opioid-based IV patient-controlled analgesia (PCA) related postoperative nausea and vomiting (PONV) in highly susceptible patients after lumbar spine surgery. SUMMARY OF BACKGROUND DATA: Optimal postoperative pain management is important to facilitate early mobilization after lumbar spine surgery. Opioid analgesia is associated with a high incidence of PONV. Among the currently available 5-hydroxytryptamine receptor 3 antagonists (5-HT3), ondansetron is being most widely used with unsatisfactory results regarding opioid-based IV PCA related PONV. Ramosetron is a newly developed 5-HT3 antagonist with higher receptor affinity and longer duration of action having theoretical advantage over ondansetron in this setting. However, data to support this view are lacking. METHODS: All 94 female nonsmoker patients (aged 18-65 years) were randomly allocated into either ondansetron group (group O, n = 47) or ramosetron group (group R, n = 47). Fentanyl-based IV PCA was administered for 48 hours after surgery. Overall incidence and severity of nausea and incidence of vomiting were assessed for 48 hours after surgery. Secondary measures included: pain intensity and total amount of administered rescue analgesic. RESULTS: Patients' characteristics were similar between the groups. Overall incidence of nausea was similar between the groups; however, moderate to severe degree of nausea was significantly more in the group O (34%) than in the group R (13%) 6 to 24 hours after surgery. Overall incidence of vomiting and use of rescue antiemetic 6 to 24 hours after surgery was significantly lower in the group R (30% vs. 11% and 28% vs. 11%, respectively). Pain scores at 24 to 48 hours after surgery were significantly lower in the group R (31 +/- 25 vs. 13 +/- 15). CONCLUSION: Ramosetron was superior to ondansetron in terms of preventing vomiting and reducing the severity of nausea related to fentanyl-based IV PCA, with less adverse events, in patients with high susceptibility, undergoing lumbar spine surgery. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | E602~E606 | - |
dc.relation.isPartOf | SPINE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adolescent | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Analgesia, Patient-Controlled/adverse effects* | - |
dc.subject.MESH | Analgesia, Patient-Controlled/methods | - |
dc.subject.MESH | Benzimidazoles/therapeutic use* | - |
dc.subject.MESH | Double-Blind Method | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Ondansetron/therapeutic use* | - |
dc.subject.MESH | Postoperative Nausea and Vomiting/etiology | - |
dc.subject.MESH | Postoperative Nausea and Vomiting/prevention & control* | - |
dc.subject.MESH | Prospective Studies | - |
dc.subject.MESH | Spinal Diseases/drug therapy | - |
dc.subject.MESH | Spinal Diseases/surgery | - |
dc.title | Effect of ramosetron on patient-controlled analgesia related nausea and vomiting after spine surgery in highly susceptible patients: comparison with ondansetron. | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Neurosurgery (신경외과학) | - |
dc.contributor.googleauthor | Yong Seon Choi | - |
dc.contributor.googleauthor | Jae Kwang Shim | - |
dc.contributor.googleauthor | Do Heum Yoon | - |
dc.contributor.googleauthor | Duck Heeh Jeon | - |
dc.contributor.googleauthor | Ji Yeon Lee | - |
dc.contributor.googleauthor | Young Lan Kwak | - |
dc.identifier.doi | 10.1097/BRS.0b013e31817c6bde | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00172 | - |
dc.contributor.localId | A02205 | - |
dc.contributor.localId | A02546 | - |
dc.contributor.localId | A03508 | - |
dc.contributor.localId | A04119 | - |
dc.contributor.localId | A03195 | - |
dc.relation.journalcode | J02674 | - |
dc.identifier.eissn | 1528-1159 | - |
dc.identifier.pmid | 18670328 | - |
dc.identifier.url | http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&AN=00007632-200808010-00021&LSLINK=80&D=ovft | - |
dc.subject.keyword | Adolescent | - |
dc.subject.keyword | Adult | - |
dc.subject.keyword | Aged | - |
dc.subject.keyword | Analgesia, Patient-Controlled/adverse effects* | - |
dc.subject.keyword | Analgesia, Patient-Controlled/methods | - |
dc.subject.keyword | Benzimidazoles/therapeutic use* | - |
dc.subject.keyword | Double-Blind Method | - |
dc.subject.keyword | Female | - |
dc.subject.keyword | Humans | - |
dc.subject.keyword | Middle Aged | - |
dc.subject.keyword | Ondansetron/therapeutic use* | - |
dc.subject.keyword | Postoperative Nausea and Vomiting/etiology | - |
dc.subject.keyword | Postoperative Nausea and Vomiting/prevention & control* | - |
dc.subject.keyword | Prospective Studies | - |
dc.subject.keyword | Spinal Diseases/drug therapy | - |
dc.subject.keyword | Spinal Diseases/surgery | - |
dc.contributor.alternativeName | Kwak, Young Lan | - |
dc.contributor.alternativeName | Shim, Jae Kwang | - |
dc.contributor.alternativeName | Yoon, Do Heum | - |
dc.contributor.alternativeName | Lee, Ji Yeon | - |
dc.contributor.alternativeName | Chun, Duk Hee | - |
dc.contributor.alternativeName | Choi, Yong Seon | - |
dc.contributor.affiliatedAuthor | Kwak, Young Lan | - |
dc.contributor.affiliatedAuthor | Shim, Jae Kwang | - |
dc.contributor.affiliatedAuthor | Yoon, Do Heum | - |
dc.contributor.affiliatedAuthor | Chun, Duk Hee | - |
dc.contributor.affiliatedAuthor | Choi, Yong Seon | - |
dc.contributor.affiliatedAuthor | Lee, Ji Yeon | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 33 | - |
dc.citation.number | 17 | - |
dc.citation.startPage | 602 | - |
dc.citation.endPage | 606 | - |
dc.identifier.bibliographicCitation | SPINE, Vol.33(17) : 602-606, 2008 | - |
dc.identifier.rimsid | 54747 | - |
dc.type.rims | ART | - |
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