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Induction of Sulfiredoxin via an Nrf2-Dependent Pathway and Hyperoxidation of Peroxiredoxin III in the Lungs of Mice Exposed to Hyperoxia

Authors
 Soo Han Bae  ;  Hyun Ae Woo  ;  Su Haeng Sung  ;  Hye Eun Lee  ;  Se Kyoung Lee  ;  In Sup Kil  ;  Sue Goo Rhee 
Citation
 Antioxidants & Redox Signaling, Vol.11(5) : 937-948, 2009 
Journal Title
 Antioxidants & Redox Signaling 
ISSN
 1523-0864 
Issue Date
2009
Abstract
The cysteine residue at the active site of peroxiredoxin (Prx) I, Prx II, or Prx III is reversibly hyperoxidized to cysteine sulfinic acid, with concomitant loss of peroxidase activity, during normal catalysis. Sulfiredoxin (Srx) is the enzyme responsible for reversing this hyperoxidation. We now show that the expression of Srx at both the mRNA and protein levels is increased markedly in the lungs of mice exposed to hyperoxia. This hyperoxia-induced expression of Srx was not evident in mice deficient in the transcription factor Nrf2, indicating an essential role for an Nrf2 signaling pathway in this effect. Hyperoxia also elicited the accumulation of the sulfinic form of the mitochondrial enzyme Prx III, but not that of the cytosolic enzymes Prx I or Prx II, in lung tissue. This selective hyperoxidation of Prx III is likely due either to mitochondria being the major site of the hyperoxia-induced production of reactive oxygen species or to the translocation of Srx from the cytosol into mitochondria being rate limiting for the reduction of sulfinic Prx III. Hyperoxia induced the degradation of Prx III in Nrf2-deficient mice but not in wild-type animals, suggesting that, in the absence of a sufficient amount of Srx, sulfinic Prx III is converted to a form that is susceptible to proteolysis
Full Text
http://online.liebertpub.com/doi/abs/10.1089/ars.2008.2325
DOI
10.1089/ARS.2008.2325
Appears in Collections:
1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부) > 1. Journal Papers
Yonsei Authors
배수한(Bae, Soo Han) ORCID logo https://orcid.org/0000-0002-8007-2906
성수행(Sung, Su Haeng)
이서구(Rhee, Sue Goo)
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/106105
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