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CTX-M-14 and CTX-M-15 enzymes are the dominant type of extended-spectrum beta-lactamase in clinical isolates of Escherichia coli from Korea

Authors
 Wonkeun Song  ;  Hyukmin Lee  ;  Kyungwon Lee  ;  Seok Hoon Jeong  ;  Il Kwon Bae  ;  Jae-Seok Kim  ;  Hyo-Sun Kwak 
Citation
 JOURNAL OF MEDICAL MICROBIOLOGY, Vol.58(pt2) : 261-266, 2009 
Journal Title
 JOURNAL OF MEDICAL MICROBIOLOGY 
ISSN
 0022-2615 
Issue Date
2009
MeSH
Anti-Bacterial Agents/pharmacology ; DNA, Bacterial/genetics ; Escherichia coli/enzymology* ; Escherichia coli/genetics ; Escherichia coli/isolation & purification ; Escherichia coli Infections/microbiology* ; Escherichia coli Proteins/biosynthesis* ; Escherichia coli Proteins/genetics ; Humans ; Korea ; Microbial Sensitivity Tests/methods ; Polymerase Chain Reaction/methods ; beta-Lactamases/biosynthesis* ; beta-Lactamases/classification ; beta-Lactamases/genetics* ; beta-Lactams/pharmacology
Abstract
This study was performed to assess the prevalence and genotypes of plasmid-borne extended-spectrum beta-lactamases (ESBLs) and AmpC beta-lactamases in Escherichia coli in Korea. A total of 576 isolates of E. coli was collected from 12 Korean hospitals during May and July 2007. A phenotypic confirmatory test detected ESBLs in 82 (14.2 %) of the 576 E. coli isolates. The most common types of ESBLs identified were CTX-M-14 (n=32) and CTX-M-15 (n=27). The prevalence and diversity of the CTX-M mutants, including CTX-M-15, CTX-M-27 and CTX-M-57, with significant hydrolytic activity against ceftazidime were increased. PCR experiments detected genes encoding plasmid-borne AmpC beta-lactamases in 15/56 cefoxitin-intermediate or cefoxitin-resistant isolates, and the most common type of AmpC beta-lactamase identified was DHA-1 (n=10). These data suggest that the incidence of ESBLs in E. coli has increased as a result of the dissemination of CTX-M enzymes in Korea. In addition, CTX-M-22, CTX-M-27 and CTX-M-57 have appeared in Korea.
Files in This Item:
T200906113.pdf Download
DOI
10.1099/jmm.0.004507-0
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
Yonsei Authors
Bae, Il Kwon(배일권)
Lee, Kyungwon(이경원) ORCID logo https://orcid.org/0000-0003-3788-2134
Jeong, Seok Hoon(정석훈) ORCID logo https://orcid.org/0000-0001-9290-897X
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/106025
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